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Protein
Submitted name:

Beta-tubulin

Gene
N/A
Organism
Plasmodium berghei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-tubulinImported
OrganismiPlasmodium bergheiImported
Taxonomic identifieri5821 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)

Subcellular locationi

  • Cytoplasmcytoskeleton SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Dimer of alpha and beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi5821.PBANKA_120690.

Structurei

3D structure databases

ProteinModelPortaliQ04200.
SMRiQ04200. Positions 1-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 243197TubulinInterPro annotationAdd
BLAST
Domaini245 – 382138Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
HOGENOMiHOG000165710.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIVHVQAG QCGNQIGAKF WEVISDEHGI DPSGTYRGDS DLQLERVDVF
60 70 80 90 100
YNEATGGRYV PRAILMDLEP GTMDSVRAGP FGQLFRPDNF VFGQTGAGNN
110 120 130 140 150
WAKGHYTEGA ELIDAVLDVV RKEAEGCDCL QGFQITHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYD RIMETFSVFP SPKVSDTVVE PYNATLSVHQ LVENADEVQV
210 220 230 240 250
IDNEALYDIC FRTLKLTTPT YGDLNHLVSA AMSGVTCSLR FPGQLNSDLR
260 270 280 290 300
KLAVNLIPFP RLHFFMIGFA PLTSRGSQQY RALTVPELTQ QMFDAKNMMC
310 320 330 340 350
ASDPRHGRYL TACAMFRGRM STKEVDEQML NVQNKNSSYF VEWIPHNTKS
360 370 380 390 400
SVCDIPPKGL KMAVTFVGNS TAIQEMFKRV SDQFTAMFRR KAFLHWYTGE
410 420 430 440
GMDEMEFTEA ESNMDLVSEY QQYQDATAEE EGEFEEEEGD VEA
Length:443
Mass (Da):49,579
Last modified:November 1, 1996 - v1
Checksum:iB68E57C44F17268D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58750 mRNA. Translation: AAA29500.1.
PIRiA45615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58750 mRNA. Translation: AAA29500.1.
PIRiA45615.

3D structure databases

ProteinModelPortaliQ04200.
SMRiQ04200. Positions 1-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5821.PBANKA_120690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
HOGENOMiHOG000165710.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence variation in the beta-tubulin genes from Plasmodium berghei and Plasmodium falciparum."
    van Belkum A., Janse C., Mons B.
    Mol. Biochem. Parasitol. 47:251-254(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Nucleotide sequence conservation in beta tubulin genes from Plasmodium berghei and Plasmodium falciparum."
    van Belkum A., Janse C., Mons B.
    Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ04200_PLABE
AccessioniPrimary (citable) accession number: Q04200
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.