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Protein
Submitted name:

Hydroxymethylglutaryl-CoA synthase

Gene

LGAS_1372

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1372-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxymethylglutaryl-CoA synthaseImported (EC:2.3.3.10Imported)
Gene namesi
Ordered Locus Names:LGAS_1372Imported
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)Imported
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi324831.LGAS_1372.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG3425.
HOGENOMiHOG000012352.
KOiK01641.
OMAiACFGLTA.
OrthoDBiEOG6HXJ54.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR011554. HMG_CoA_synthase_prok.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01835. HMG-CoA-S_prok. 1 hit.

Sequencei

Sequence statusi: Complete.

Q041Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVGIDQIGY FTPNKYVDMV DLAHARNQDP NKFLIGIGQK KMSVADPTQD
60 70 80 90 100
AVSMGINATL RYIDKIDQSK VGLLIFGTES SVDQSKSGSL FVKSALKLDP
110 120 130 140 150
AVRAFEVKEA CFGLTAGLMI AQDFVRLHPD QTAIVIGSDI ARYGINTAGE
160 170 180 190 200
VTQGAGSVSL LVSSNPRILE LNEGHSAYSE DINDFWRPNY SKTAKVDGKY
210 220 230 240 250
STQVYLDFFK HTFSDYKRQK GLETKDFAAI AYHLPFTKMG LKANRLAIEG
260 270 280 290 300
VDEETNARLM DSFTASKELN ANVGNIYTGS LYLSLLSLLE NGGLKAGDLI
310 320 330 340 350
GLFSYGSGAM AEFYSANVVE GYENELDKAA DEALLDKRRK LSVPEYEKIF
360 370 380
SASLVDPQNN VELTSDEKKG RYYFAGICDD IRQYRVK
Length:387
Mass (Da):42,696
Last modified:November 14, 2006 - v1
Checksum:iA9EBF24443EE6070
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60734.1.
RefSeqiYP_815172.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60734; ABJ60734; LGAS_1372.
GeneIDi4439423.
KEGGilga:LGAS_1372.
PATRICi22230915. VBILacGas62225_1361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60734.1.
RefSeqiYP_815172.1. NC_008530.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324831.LGAS_1372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ60734; ABJ60734; LGAS_1372.
GeneIDi4439423.
KEGGilga:LGAS_1372.
PATRICi22230915. VBILacGas62225_1361.

Phylogenomic databases

eggNOGiCOG3425.
HOGENOMiHOG000012352.
KOiK01641.
OMAiACFGLTA.
OrthoDBiEOG6HXJ54.

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1372-MONOMER.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR011554. HMG_CoA_synthase_prok.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01835. HMG-CoA-S_prok. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63Imported.

Entry informationi

Entry nameiQ041Y8_LACGA
AccessioniPrimary (citable) accession number: Q041Y8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: March 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.