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Q041S2

- TRMB_LACGA

UniProt

Q041S2 - TRMB_LACGA

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, LGAS_1441
Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461S-adenosyl-L-methionine By similarity
Binding sitei71 – 711S-adenosyl-L-methionine By similarity
Binding sitei98 – 981S-adenosyl-L-methionine By similarity
Active sitei120 – 1201 By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine By similarity
Binding sitei124 – 1241Substrate By similarity
Binding sitei156 – 1561Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1441-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:LGAS_1441
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000288165Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324831.LGAS_1441.

Structurei

3D structure databases

ProteinModelPortaliQ041S2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1316Interaction with RNA Reviewed prediction
Regioni196 – 1994Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q041S2-1 [UniParc]FASTAAdd to Basket

« Hide

MRLRNKPWAQ KLVVEHPEAI LNEPDPEKKI NWEERFDDFS KPLAIEIGSG    50
KGQFITTLAK KHPEMNFIGV ELQTTAAGMI LRTKLEEKID NLQLMCADAA 100
NIAMYLPENS VDVVYLNFSD PWPKTRHEKR RLTYKSFLDK YRQILKPEGH 150
LEFKTDNQGL FEYSLVSLNN YGMKFDYVSL DLHHAENEIL ERNVETEYEH 200
KFAAKGNPIY CLHAHFE 217
Length:217
Mass (Da):25,371
Last modified:November 14, 2006 - v1
Checksum:i734B88A91EDC499D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000413 Genomic DNA. Translation: ABJ60800.1.
RefSeqiYP_815238.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60800; ABJ60800; LGAS_1441.
GeneIDi4439352.
KEGGilga:LGAS_1441.
PATRICi22231047. VBILacGas62225_1427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000413 Genomic DNA. Translation: ABJ60800.1 .
RefSeqi YP_815238.1. NC_008530.1.

3D structure databases

ProteinModelPortali Q041S2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324831.LGAS_1441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ60800 ; ABJ60800 ; LGAS_1441 .
GeneIDi 4439352.
KEGGi lga:LGAS_1441.
PATRICi 22231047. VBILacGas62225_1427.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci LGAS324831:GHTY-1441-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243.

Entry informationi

Entry nameiTRMB_LACGA
AccessioniPrimary (citable) accession number: Q041S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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