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Q041L3

- RTPR_LACGA

UniProt

Q041L3 - RTPR_LACGA

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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei413 – 4131By similarity
Active sitei415 – 4151By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LGAS_1503
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 424Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ041L3.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi324831.LGAS_1503.

Structurei

3D structure databases

ProteinModelPortaliQ041L3.
SMRiQ041L3. Positions 6-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 15912Effector region-1By similarityAdd
BLAST
Regioni169 – 318150Effector region-2By similarityAdd
BLAST
Regioni570 – 63162Adenosylcobalamin-binding-1By similarityAdd
BLAST
Regioni690 – 72940Adenosylcobalamin-binding-2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00525.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q041L3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLRITLDP DFIAQTKKEV TPHWGELGWV TYKRTYARWL DDKNRSENWD
60 70 80 90 100
ETVKRVIEGN INLDPRLKNN PSKKTIHELT AEAKQLFRLV YGLAATPSGR
110 120 130 140 150
NLWISGTDYQ KRNGDSLNNC WFISIRPQKY GNSHIVPAYL TQDQVAPSMP
160 170 180 190 200
FSFLFDQLMK GGGVGFSVVD ENINQIPKLD QKVDLTIVID KQSKSYDASL
210 220 230 240 250
KLGATDLDEW KKTNQEKEDY IYYKLPDTRE GWVLANARLI DMHFNSTNPE
260 270 280 290 300
NKKKLVLDIS DIRPYGAKIH GFGGTASGPM PLIEMLFDIN QILNERAGQK
310 320 330 340 350
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSNNQDFIT MKQDKKKLYH
360 370 380 390 400
HRWASNNSVA INSEFDNYQP IADSILHNGE PGVVNLELSR NYGRIKDGYQ
410 420 430 440 450
AGIDGEVEGT NPCGEISLAN GEPCNLFEVF PFIAQKQGWD LKEAFKLAAR
460 470 480 490 500
YTKRVTFSPY DWEVSRKIIN KNRRIGVSMS GIQDWILSTF GHRVVTGFKT
510 520 530 540 550
ATDSETGKEI KDPVYDPEII KTVDGLYQAV VDADKDYSQE LNCNTSIKHT
560 570 580 590 600
TVKPSGTVAK LAGVSEGMHF HYSGYLIQRI RFQETDPLLP ALKDCGYRTE
610 620 630 640 650
PDIYTPHTIC VEFPIKAANA DSDNFASAGT VSIAEQFATQ AFLQTYWSDN
660 670 680 690 700
AVSCTITFQN DESDQIAPLL HQYRYAIKST SLLPYYGGSL KQAPKEPISK
710 720 730 740
EKYEKADNHI TGNVEIVFEQ TNEDQKGLEL VDQSDCDNGA CPIK
Length:744
Mass (Da):83,638
Last modified:April 8, 2008 - v2
Checksum:iFB8C507078BC8CED
GO

Sequence cautioni

The sequence ABJ60859.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60859.1. Different initiation.
RefSeqiYP_815297.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60859; ABJ60859; LGAS_1503.
GeneIDi4439293.
KEGGilga:LGAS_1503.
PATRICi22231167. VBILacGas62225_1486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60859.1 . Different initiation.
RefSeqi YP_815297.1. NC_008530.1.

3D structure databases

ProteinModelPortali Q041L3.
SMRi Q041L3. Positions 6-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324831.LGAS_1503.

Proteomic databases

PRIDEi Q041L3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ60859 ; ABJ60859 ; LGAS_1503 .
GeneIDi 4439293.
KEGGi lga:LGAS_1503.
PATRICi 22231167. VBILacGas62225_1486.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00525.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LGAS324831:GHTY-1503-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243.

Entry informationi

Entry nameiRTPR_LACGA
AccessioniPrimary (citable) accession number: Q041L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3