Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q041L3 (RTPR_LACGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
Ordered Locus Names:LGAS_1503
OrganismLactobacillus gasseri (strain ATCC 33323 / DSM 20243) [Complete proteome] [HAMAP]
Taxonomic identifier324831 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length744 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Enzyme regulation

Allosterically regulated by ATP and dNTP By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence caution

The sequence ABJ60859.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326541

Regions

Region148 – 15912Effector region-1 By similarity
Region169 – 318150Effector region-2 By similarity
Region570 – 63162Adenosylcobalamin-binding-1 By similarity
Region690 – 72940Adenosylcobalamin-binding-2 By similarity

Sites

Active site4131 By similarity
Active site4151 By similarity

Amino acid modifications

Disulfide bond120 ↔ 424Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q041L3 [UniParc].

Last modified April 8, 2008. Version 2.
Checksum: FB8C507078BC8CED

FASTA74483,638
        10         20         30         40         50         60 
MSDLRITLDP DFIAQTKKEV TPHWGELGWV TYKRTYARWL DDKNRSENWD ETVKRVIEGN 

        70         80         90        100        110        120 
INLDPRLKNN PSKKTIHELT AEAKQLFRLV YGLAATPSGR NLWISGTDYQ KRNGDSLNNC 

       130        140        150        160        170        180 
WFISIRPQKY GNSHIVPAYL TQDQVAPSMP FSFLFDQLMK GGGVGFSVVD ENINQIPKLD 

       190        200        210        220        230        240 
QKVDLTIVID KQSKSYDASL KLGATDLDEW KKTNQEKEDY IYYKLPDTRE GWVLANARLI 

       250        260        270        280        290        300 
DMHFNSTNPE NKKKLVLDIS DIRPYGAKIH GFGGTASGPM PLIEMLFDIN QILNERAGQK 

       310        320        330        340        350        360 
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSNNQDFIT MKQDKKKLYH HRWASNNSVA 

       370        380        390        400        410        420 
INSEFDNYQP IADSILHNGE PGVVNLELSR NYGRIKDGYQ AGIDGEVEGT NPCGEISLAN 

       430        440        450        460        470        480 
GEPCNLFEVF PFIAQKQGWD LKEAFKLAAR YTKRVTFSPY DWEVSRKIIN KNRRIGVSMS 

       490        500        510        520        530        540 
GIQDWILSTF GHRVVTGFKT ATDSETGKEI KDPVYDPEII KTVDGLYQAV VDADKDYSQE 

       550        560        570        580        590        600 
LNCNTSIKHT TVKPSGTVAK LAGVSEGMHF HYSGYLIQRI RFQETDPLLP ALKDCGYRTE 

       610        620        630        640        650        660 
PDIYTPHTIC VEFPIKAANA DSDNFASAGT VSIAEQFATQ AFLQTYWSDN AVSCTITFQN 

       670        680        690        700        710        720 
DESDQIAPLL HQYRYAIKST SLLPYYGGSL KQAPKEPISK EKYEKADNHI TGNVEIVFEQ 

       730        740 
TNEDQKGLEL VDQSDCDNGA CPIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000413 Genomic DNA. Translation: ABJ60859.1. Different initiation.
RefSeqYP_815297.1. NC_008530.1.

3D structure databases

ProteinModelPortalQ041L3.
SMRQ041L3. Positions 6-729.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324831.LGAS_1503.

Proteomic databases

PRIDEQ041L3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ60859; ABJ60859; LGAS_1503.
GeneID4439293.
KEGGlga:LGAS_1503.
PATRIC22231167. VBILacGas62225_1486.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1372.
HOGENOMHOG000068540.
KOK00525.
OrthoDBEOG68DCVH.

Enzyme and pathway databases

BioCycLGAS324831:GHTY-1503-MONOMER.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_LACGA
AccessionPrimary (citable) accession number: Q041L3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families