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Q041L3

- RTPR_LACGA

UniProt

Q041L3 - RTPR_LACGA

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Enzyme regulationi

    Allosterically regulated by ATP and dNTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei413 – 4131By similarity
    Active sitei415 – 4151By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Enzyme and pathway databases

    BioCyciLGAS324831:GHTY-1503-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    Ordered Locus Names:LGAS_1503
    OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
    Taxonomic identifieri324831 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000664: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326541Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi120 ↔ 424Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ041L3.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi324831.LGAS_1503.

    Structurei

    3D structure databases

    ProteinModelPortaliQ041L3.
    SMRiQ041L3. Positions 6-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni148 – 15912Effector region-1By similarityAdd
    BLAST
    Regioni169 – 318150Effector region-2By similarityAdd
    BLAST
    Regioni570 – 63162Adenosylcobalamin-binding-1By similarityAdd
    BLAST
    Regioni690 – 72940Adenosylcobalamin-binding-2By similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000068540.
    KOiK00525.
    OrthoDBiEOG68DCVH.

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q041L3-1 [UniParc]FASTAAdd to Basket

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    MSDLRITLDP DFIAQTKKEV TPHWGELGWV TYKRTYARWL DDKNRSENWD    50
    ETVKRVIEGN INLDPRLKNN PSKKTIHELT AEAKQLFRLV YGLAATPSGR 100
    NLWISGTDYQ KRNGDSLNNC WFISIRPQKY GNSHIVPAYL TQDQVAPSMP 150
    FSFLFDQLMK GGGVGFSVVD ENINQIPKLD QKVDLTIVID KQSKSYDASL 200
    KLGATDLDEW KKTNQEKEDY IYYKLPDTRE GWVLANARLI DMHFNSTNPE 250
    NKKKLVLDIS DIRPYGAKIH GFGGTASGPM PLIEMLFDIN QILNERAGQK 300
    LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSNNQDFIT MKQDKKKLYH 350
    HRWASNNSVA INSEFDNYQP IADSILHNGE PGVVNLELSR NYGRIKDGYQ 400
    AGIDGEVEGT NPCGEISLAN GEPCNLFEVF PFIAQKQGWD LKEAFKLAAR 450
    YTKRVTFSPY DWEVSRKIIN KNRRIGVSMS GIQDWILSTF GHRVVTGFKT 500
    ATDSETGKEI KDPVYDPEII KTVDGLYQAV VDADKDYSQE LNCNTSIKHT 550
    TVKPSGTVAK LAGVSEGMHF HYSGYLIQRI RFQETDPLLP ALKDCGYRTE 600
    PDIYTPHTIC VEFPIKAANA DSDNFASAGT VSIAEQFATQ AFLQTYWSDN 650
    AVSCTITFQN DESDQIAPLL HQYRYAIKST SLLPYYGGSL KQAPKEPISK 700
    EKYEKADNHI TGNVEIVFEQ TNEDQKGLEL VDQSDCDNGA CPIK 744
    Length:744
    Mass (Da):83,638
    Last modified:April 8, 2008 - v2
    Checksum:iFB8C507078BC8CED
    GO

    Sequence cautioni

    The sequence ABJ60859.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000413 Genomic DNA. Translation: ABJ60859.1. Different initiation.
    RefSeqiYP_815297.1. NC_008530.1.

    Genome annotation databases

    EnsemblBacteriaiABJ60859; ABJ60859; LGAS_1503.
    GeneIDi4439293.
    KEGGilga:LGAS_1503.
    PATRICi22231167. VBILacGas62225_1486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000413 Genomic DNA. Translation: ABJ60859.1 . Different initiation.
    RefSeqi YP_815297.1. NC_008530.1.

    3D structure databases

    ProteinModelPortali Q041L3.
    SMRi Q041L3. Positions 6-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324831.LGAS_1503.

    Proteomic databases

    PRIDEi Q041L3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ60859 ; ABJ60859 ; LGAS_1503 .
    GeneIDi 4439293.
    KEGGi lga:LGAS_1503.
    PATRICi 22231167. VBILacGas62225_1486.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000068540.
    KOi K00525.
    OrthoDBi EOG68DCVH.

    Enzyme and pathway databases

    BioCyci LGAS324831:GHTY-1503-MONOMER.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33323 / DSM 20243.

    Entry informationi

    Entry nameiRTPR_LACGA
    AccessioniPrimary (citable) accession number: Q041L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3