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Q041L3

- RTPR_LACGA

UniProt

Q041L3 - RTPR_LACGA

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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene
rtpR, LGAS_1503
Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin By similarity.

Enzyme regulationi

Allosterically regulated by ATP and dNTP By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei413 – 4131 By similarity
Active sitei415 – 4151 By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LGAS_1503
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 424Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ041L3.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi324831.LGAS_1503.

Structurei

3D structure databases

ProteinModelPortaliQ041L3.
SMRiQ041L3. Positions 6-729.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 15912Effector region-1 By similarityAdd
BLAST
Regioni169 – 318150Effector region-2 By similarityAdd
BLAST
Regioni570 – 63162Adenosylcobalamin-binding-1 By similarityAdd
BLAST
Regioni690 – 72940Adenosylcobalamin-binding-2 By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00525.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q041L3-1 [UniParc]FASTAAdd to Basket

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MSDLRITLDP DFIAQTKKEV TPHWGELGWV TYKRTYARWL DDKNRSENWD    50
ETVKRVIEGN INLDPRLKNN PSKKTIHELT AEAKQLFRLV YGLAATPSGR 100
NLWISGTDYQ KRNGDSLNNC WFISIRPQKY GNSHIVPAYL TQDQVAPSMP 150
FSFLFDQLMK GGGVGFSVVD ENINQIPKLD QKVDLTIVID KQSKSYDASL 200
KLGATDLDEW KKTNQEKEDY IYYKLPDTRE GWVLANARLI DMHFNSTNPE 250
NKKKLVLDIS DIRPYGAKIH GFGGTASGPM PLIEMLFDIN QILNERAGQK 300
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSNNQDFIT MKQDKKKLYH 350
HRWASNNSVA INSEFDNYQP IADSILHNGE PGVVNLELSR NYGRIKDGYQ 400
AGIDGEVEGT NPCGEISLAN GEPCNLFEVF PFIAQKQGWD LKEAFKLAAR 450
YTKRVTFSPY DWEVSRKIIN KNRRIGVSMS GIQDWILSTF GHRVVTGFKT 500
ATDSETGKEI KDPVYDPEII KTVDGLYQAV VDADKDYSQE LNCNTSIKHT 550
TVKPSGTVAK LAGVSEGMHF HYSGYLIQRI RFQETDPLLP ALKDCGYRTE 600
PDIYTPHTIC VEFPIKAANA DSDNFASAGT VSIAEQFATQ AFLQTYWSDN 650
AVSCTITFQN DESDQIAPLL HQYRYAIKST SLLPYYGGSL KQAPKEPISK 700
EKYEKADNHI TGNVEIVFEQ TNEDQKGLEL VDQSDCDNGA CPIK 744
Length:744
Mass (Da):83,638
Last modified:April 8, 2008 - v2
Checksum:iFB8C507078BC8CED
GO

Sequence cautioni

The sequence ABJ60859.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000413 Genomic DNA. Translation: ABJ60859.1. Different initiation.
RefSeqiYP_815297.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60859; ABJ60859; LGAS_1503.
GeneIDi4439293.
KEGGilga:LGAS_1503.
PATRICi22231167. VBILacGas62225_1486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000413 Genomic DNA. Translation: ABJ60859.1 . Different initiation.
RefSeqi YP_815297.1. NC_008530.1.

3D structure databases

ProteinModelPortali Q041L3.
SMRi Q041L3. Positions 6-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324831.LGAS_1503.

Proteomic databases

PRIDEi Q041L3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ60859 ; ABJ60859 ; LGAS_1503 .
GeneIDi 4439293.
KEGGi lga:LGAS_1503.
PATRICi 22231167. VBILacGas62225_1486.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00525.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LGAS324831:GHTY-1503-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243.

Entry informationi

Entry nameiRTPR_LACGA
AccessioniPrimary (citable) accession number: Q041L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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