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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei413By similarity1
Active sitei415By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
Biological processDNA replication
LigandCobalamin, Cobalt

Enzyme and pathway databases

BioCyciLGAS324831:G1G6Y-1498-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LGAS_1503
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003265411 – 744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductaseAdd BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 424Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ041L3
SMRiQ041L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni148 – 159Effector region-1By similarityAdd BLAST12
Regioni169 – 318Effector region-2By similarityAdd BLAST150
Regioni570 – 631Adenosylcobalamin-binding-1By similarityAdd BLAST62
Regioni690 – 729Adenosylcobalamin-binding-2By similarityAdd BLAST40

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4107VC8 Bacteria
COG1372 LUCA
HOGENOMiHOG000068540
KOiK00527

Family and domain databases

InterProiView protein in InterPro
IPR000788 RNR_lg_C
IPR013345 RTP_Rdtase_AdoCbl-dep
PfamiView protein in Pfam
PF02867 Ribonuc_red_lgC, 1 hit
TIGRFAMsiTIGR02505 RTPR, 1 hit

Sequencei

Sequence statusi: Complete.

Q041L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLRITLDP DFIAQTKKEV TPHWGELGWV TYKRTYARWL DDKNRSENWD
60 70 80 90 100
ETVKRVIEGN INLDPRLKNN PSKKTIHELT AEAKQLFRLV YGLAATPSGR
110 120 130 140 150
NLWISGTDYQ KRNGDSLNNC WFISIRPQKY GNSHIVPAYL TQDQVAPSMP
160 170 180 190 200
FSFLFDQLMK GGGVGFSVVD ENINQIPKLD QKVDLTIVID KQSKSYDASL
210 220 230 240 250
KLGATDLDEW KKTNQEKEDY IYYKLPDTRE GWVLANARLI DMHFNSTNPE
260 270 280 290 300
NKKKLVLDIS DIRPYGAKIH GFGGTASGPM PLIEMLFDIN QILNERAGQK
310 320 330 340 350
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSNNQDFIT MKQDKKKLYH
360 370 380 390 400
HRWASNNSVA INSEFDNYQP IADSILHNGE PGVVNLELSR NYGRIKDGYQ
410 420 430 440 450
AGIDGEVEGT NPCGEISLAN GEPCNLFEVF PFIAQKQGWD LKEAFKLAAR
460 470 480 490 500
YTKRVTFSPY DWEVSRKIIN KNRRIGVSMS GIQDWILSTF GHRVVTGFKT
510 520 530 540 550
ATDSETGKEI KDPVYDPEII KTVDGLYQAV VDADKDYSQE LNCNTSIKHT
560 570 580 590 600
TVKPSGTVAK LAGVSEGMHF HYSGYLIQRI RFQETDPLLP ALKDCGYRTE
610 620 630 640 650
PDIYTPHTIC VEFPIKAANA DSDNFASAGT VSIAEQFATQ AFLQTYWSDN
660 670 680 690 700
AVSCTITFQN DESDQIAPLL HQYRYAIKST SLLPYYGGSL KQAPKEPISK
710 720 730 740
EKYEKADNHI TGNVEIVFEQ TNEDQKGLEL VDQSDCDNGA CPIK
Length:744
Mass (Da):83,638
Last modified:April 8, 2008 - v2
Checksum:iFB8C507078BC8CED
GO

Sequence cautioni

The sequence ABJ60859 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA Translation: ABJ60859.1 Different initiation.
RefSeqiWP_021314961.1, NZ_BALQ01000003.1

Genome annotation databases

EnsemblBacteriaiABJ60859; ABJ60859; LGAS_1503
GeneIDi29638635
KEGGilga:LGAS_1503

Entry informationi

Entry nameiRTPR_LACGA
AccessioniPrimary (citable) accession number: Q041L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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