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Q04199

- CAC2_YEAST

UniProt

Q04199 - CAC2_YEAST

Protein

Chromatin assembly factor 1 subunit p60

Gene

CAC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts By similarity.By similarity

    GO - Biological processi

    1. DNA replication-dependent nucleosome assembly Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32686-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromatin assembly factor 1 subunit p60
    Alternative name(s):
    CAF-1 60 kDa subunit
    Gene namesi
    Name:CAC2
    Ordered Locus Names:YML102W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML102w.
    SGDiS000004570. CAC2.

    Subcellular locationi

    GO - Cellular componenti

    1. CAF-1 complex Source: SGD
    2. chromosome, centromeric region Source: SGD
    3. cytosol Source: SGD
    4. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Chromatin assembly factor 1 subunit p60PRO_0000050894Add
    BLAST

    Proteomic databases

    MaxQBiQ04199.
    PaxDbiQ04199.
    PeptideAtlasiQ04199.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04199.

    Interactioni

    Subunit structurei

    Component of chromatin assembly factor 1 (CAF-1), which is composed of MSI1/p50, CAC2/p60 and CAC1/p90.

    Protein-protein interaction databases

    BioGridi35041. 118 interactions.
    DIPiDIP-811N.
    IntActiQ04199. 6 interactions.
    MINTiMINT-552288.
    STRINGi4932.YML102W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04199.
    SMRiQ04199. Positions 32-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 5242WD 1Add
    BLAST
    Repeati69 – 10840WD 2Add
    BLAST
    Repeati143 – 18240WD 3Add
    BLAST
    Repeati185 – 22440WD 4Add
    BLAST
    Repeati371 – 41343WD 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat HIR1 family.Curated
    Contains 5 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00550000074968.
    HOGENOMiHOG000183312.
    KOiK10751.
    OMAiCTIIEFE.
    OrthoDBiEOG7NCVC9.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 5 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEASHLQIYW HDSQPVYSLT FQKNSANDKL FTAGGDNKVR IWKLNRDENG    50
    QNGGVRKIES LDFLGSLTHH EQAINVIRFN SKGDVLASAG DDGQVLLWKQ 100
    EDPNTQQESV VRPFGMDAET SEADENKEKW VVWKRLRGGS GATAAAEIYD 150
    LAWSPDNRNI VVACMDNSIR LFDVGAGMLV CGQSDHGHYV QGVAWDPLNQ 200
    FILSQSADRS LHVYGVILSS AGVVTGLKLR SKIAKAELPC PGDVLRTNYL 250
    FHNETLPSFF RRCSISPCGG LVVIPSGVYK VAGDEVANCV YVYTRSGILN 300
    SAGGVKNRPA IRIPSLKKPA LMAAFSPVFY ETCQKSVLKL PYKLVFAIAT 350
    TNEVLVYDTD VLEPLCVVGN IHYSPITDLA WSEDGSTLLI SSTDGFCSYV 400
    SIDTETQFGS RIEPPAMHAE PLDTDESAVA AKNQREAGGI VNMLPVKKIP 450
    CNSSDSKKRR IHPTPVDL 468
    Length:468
    Mass (Da):51,252
    Last modified:November 1, 1997 - v1
    Checksum:iF24853C4AA4D97C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80835 Genomic DNA. Translation: CAA56795.1.
    BK006946 Genomic DNA. Translation: DAA09796.1.
    PIRiS47447.
    RefSeqiNP_013605.1. NM_001182464.1.

    Genome annotation databases

    EnsemblFungiiYML102W; YML102W; YML102W.
    GeneIDi854869.
    KEGGisce:YML102W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80835 Genomic DNA. Translation: CAA56795.1 .
    BK006946 Genomic DNA. Translation: DAA09796.1 .
    PIRi S47447.
    RefSeqi NP_013605.1. NM_001182464.1.

    3D structure databases

    ProteinModelPortali Q04199.
    SMRi Q04199. Positions 32-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35041. 118 interactions.
    DIPi DIP-811N.
    IntActi Q04199. 6 interactions.
    MINTi MINT-552288.
    STRINGi 4932.YML102W.

    Proteomic databases

    MaxQBi Q04199.
    PaxDbi Q04199.
    PeptideAtlasi Q04199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML102W ; YML102W ; YML102W .
    GeneIDi 854869.
    KEGGi sce:YML102W.

    Organism-specific databases

    CYGDi YML102w.
    SGDi S000004570. CAC2.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00550000074968.
    HOGENOMi HOG000183312.
    KOi K10751.
    OMAi CTIIEFE.
    OrthoDBi EOG7NCVC9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32686-MONOMER.

    Miscellaneous databases

    NextBioi 977801.
    PROi Q04199.

    Gene expression databases

    Genevestigatori Q04199.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 5 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I."
      Kaufman P.D., Kobayashi R., Stillman B.
      Genes Dev. 11:345-357(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 58-83 AND 459-468, CHARACTERIZATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCAC2_YEAST
    AccessioniPrimary (citable) accession number: Q04199
    Secondary accession number(s): D6W0I2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2130 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3