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Protein

Chromatin assembly factor 1 subunit p60

Gene

CAC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts (By similarity).By similarity

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • DNA replication-dependent nucleosome assembly Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32686-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin assembly factor 1 subunit p60
Alternative name(s):
CAF-1 60 kDa subunit
Gene namesi
Name:CAC2
Ordered Locus Names:YML102W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML102W
SGDiS000004570 CAC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508941 – 468Chromatin assembly factor 1 subunit p60Add BLAST468

Proteomic databases

MaxQBiQ04199
PaxDbiQ04199
PRIDEiQ04199

Interactioni

Subunit structurei

Component of chromatin assembly factor 1 (CAF-1), which is composed of MSI1/p50, CAC2/p60 and CAC1/p90.

Binary interactionsi

WithEntry#Exp.IntActNotes
MSI1P137123EBI-3920,EBI-11391

Protein-protein interaction databases

BioGridi35041, 199 interactors
DIPiDIP-811N
IntActiQ04199, 13 interactors
MINTiQ04199
STRINGi4932.YML102W

Structurei

3D structure databases

ProteinModelPortaliQ04199
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 52WD 1Add BLAST42
Repeati69 – 108WD 2Add BLAST40
Repeati143 – 182WD 3Add BLAST40
Repeati185 – 224WD 4Add BLAST40
Repeati371 – 413WD 5Add BLAST43

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00550000074968
HOGENOMiHOG000183312
InParanoidiQ04199
KOiK10751
OMAiVYDICWT
OrthoDBiEOG092C0UNU

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q04199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASHLQIYW HDSQPVYSLT FQKNSANDKL FTAGGDNKVR IWKLNRDENG
60 70 80 90 100
QNGGVRKIES LDFLGSLTHH EQAINVIRFN SKGDVLASAG DDGQVLLWKQ
110 120 130 140 150
EDPNTQQESV VRPFGMDAET SEADENKEKW VVWKRLRGGS GATAAAEIYD
160 170 180 190 200
LAWSPDNRNI VVACMDNSIR LFDVGAGMLV CGQSDHGHYV QGVAWDPLNQ
210 220 230 240 250
FILSQSADRS LHVYGVILSS AGVVTGLKLR SKIAKAELPC PGDVLRTNYL
260 270 280 290 300
FHNETLPSFF RRCSISPCGG LVVIPSGVYK VAGDEVANCV YVYTRSGILN
310 320 330 340 350
SAGGVKNRPA IRIPSLKKPA LMAAFSPVFY ETCQKSVLKL PYKLVFAIAT
360 370 380 390 400
TNEVLVYDTD VLEPLCVVGN IHYSPITDLA WSEDGSTLLI SSTDGFCSYV
410 420 430 440 450
SIDTETQFGS RIEPPAMHAE PLDTDESAVA AKNQREAGGI VNMLPVKKIP
460
CNSSDSKKRR IHPTPVDL
Length:468
Mass (Da):51,252
Last modified:November 1, 1997 - v1
Checksum:iF24853C4AA4D97C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80835 Genomic DNA Translation: CAA56795.1
BK006946 Genomic DNA Translation: DAA09796.1
PIRiS47447
RefSeqiNP_013605.1, NM_001182464.1

Genome annotation databases

EnsemblFungiiYML102W; YML102W; YML102W
GeneIDi854869
KEGGisce:YML102W

Similar proteinsi

Entry informationi

Entry nameiCAC2_YEAST
AccessioniPrimary (citable) accession number: Q04199
Secondary accession number(s): D6W0I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health