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Q04199

- CAC2_YEAST

UniProt

Q04199 - CAC2_YEAST

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Protein

Chromatin assembly factor 1 subunit p60

Gene
CAC2, YML102W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts By similarity.

GO - Biological processi

  1. DNA replication-dependent nucleosome assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32686-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin assembly factor 1 subunit p60
Alternative name(s):
CAF-1 60 kDa subunit
Gene namesi
Name:CAC2
Ordered Locus Names:YML102W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML102w.
SGDiS000004570. CAC2.

Subcellular locationi

GO - Cellular componenti

  1. CAF-1 complex Source: SGD
  2. chromosome, centromeric region Source: SGD
  3. cytosol Source: SGD
  4. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Chromatin assembly factor 1 subunit p60PRO_0000050894Add
BLAST

Proteomic databases

MaxQBiQ04199.
PaxDbiQ04199.
PeptideAtlasiQ04199.

Expressioni

Gene expression databases

GenevestigatoriQ04199.

Interactioni

Subunit structurei

Component of chromatin assembly factor 1 (CAF-1), which is composed of MSI1/p50, CAC2/p60 and CAC1/p90.

Protein-protein interaction databases

BioGridi35041. 118 interactions.
DIPiDIP-811N.
IntActiQ04199. 6 interactions.
MINTiMINT-552288.
STRINGi4932.YML102W.

Structurei

3D structure databases

ProteinModelPortaliQ04199.
SMRiQ04199. Positions 32-214.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5242WD 1Add
BLAST
Repeati69 – 10840WD 2Add
BLAST
Repeati143 – 18240WD 3Add
BLAST
Repeati185 – 22440WD 4Add
BLAST
Repeati371 – 41343WD 5Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.
Contains 5 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00550000074968.
HOGENOMiHOG000183312.
KOiK10751.
OMAiCTIIEFE.
OrthoDBiEOG7NCVC9.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04199-1 [UniParc]FASTAAdd to Basket

« Hide

MEASHLQIYW HDSQPVYSLT FQKNSANDKL FTAGGDNKVR IWKLNRDENG    50
QNGGVRKIES LDFLGSLTHH EQAINVIRFN SKGDVLASAG DDGQVLLWKQ 100
EDPNTQQESV VRPFGMDAET SEADENKEKW VVWKRLRGGS GATAAAEIYD 150
LAWSPDNRNI VVACMDNSIR LFDVGAGMLV CGQSDHGHYV QGVAWDPLNQ 200
FILSQSADRS LHVYGVILSS AGVVTGLKLR SKIAKAELPC PGDVLRTNYL 250
FHNETLPSFF RRCSISPCGG LVVIPSGVYK VAGDEVANCV YVYTRSGILN 300
SAGGVKNRPA IRIPSLKKPA LMAAFSPVFY ETCQKSVLKL PYKLVFAIAT 350
TNEVLVYDTD VLEPLCVVGN IHYSPITDLA WSEDGSTLLI SSTDGFCSYV 400
SIDTETQFGS RIEPPAMHAE PLDTDESAVA AKNQREAGGI VNMLPVKKIP 450
CNSSDSKKRR IHPTPVDL 468
Length:468
Mass (Da):51,252
Last modified:November 1, 1997 - v1
Checksum:iF24853C4AA4D97C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80835 Genomic DNA. Translation: CAA56795.1.
BK006946 Genomic DNA. Translation: DAA09796.1.
PIRiS47447.
RefSeqiNP_013605.1. NM_001182464.1.

Genome annotation databases

EnsemblFungiiYML102W; YML102W; YML102W.
GeneIDi854869.
KEGGisce:YML102W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80835 Genomic DNA. Translation: CAA56795.1 .
BK006946 Genomic DNA. Translation: DAA09796.1 .
PIRi S47447.
RefSeqi NP_013605.1. NM_001182464.1.

3D structure databases

ProteinModelPortali Q04199.
SMRi Q04199. Positions 32-214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35041. 118 interactions.
DIPi DIP-811N.
IntActi Q04199. 6 interactions.
MINTi MINT-552288.
STRINGi 4932.YML102W.

Proteomic databases

MaxQBi Q04199.
PaxDbi Q04199.
PeptideAtlasi Q04199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML102W ; YML102W ; YML102W .
GeneIDi 854869.
KEGGi sce:YML102W.

Organism-specific databases

CYGDi YML102w.
SGDi S000004570. CAC2.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00550000074968.
HOGENOMi HOG000183312.
KOi K10751.
OMAi CTIIEFE.
OrthoDBi EOG7NCVC9.

Enzyme and pathway databases

BioCyci YEAST:G3O-32686-MONOMER.

Miscellaneous databases

NextBioi 977801.
PROi Q04199.

Gene expression databases

Genevestigatori Q04199.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 5 hits.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I."
    Kaufman P.D., Kobayashi R., Stillman B.
    Genes Dev. 11:345-357(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 58-83 AND 459-468, CHARACTERIZATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAC2_YEAST
AccessioniPrimary (citable) accession number: Q04199
Secondary accession number(s): D6W0I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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