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Protein

Chromatin assembly factor 1 subunit p60

Gene

CAC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts (By similarity).By similarity

GO - Biological processi

  • DNA replication-dependent nucleosome assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32686-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin assembly factor 1 subunit p60
Alternative name(s):
CAF-1 60 kDa subunit
Gene namesi
Name:CAC2
Ordered Locus Names:YML102W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML102W.
SGDiS000004570. CAC2.

Subcellular locationi

GO - Cellular componenti

  • CAF-1 complex Source: SGD
  • chromosome, centromeric region Source: SGD
  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508941 – 468Chromatin assembly factor 1 subunit p60Add BLAST468

Proteomic databases

MaxQBiQ04199.
PRIDEiQ04199.

Interactioni

Subunit structurei

Component of chromatin assembly factor 1 (CAF-1), which is composed of MSI1/p50, CAC2/p60 and CAC1/p90.

Protein-protein interaction databases

BioGridi35041. 119 interactors.
DIPiDIP-811N.
IntActiQ04199. 7 interactors.
MINTiMINT-552288.

Structurei

3D structure databases

ProteinModelPortaliQ04199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 52WD 1Add BLAST42
Repeati69 – 108WD 2Add BLAST40
Repeati143 – 182WD 3Add BLAST40
Repeati185 – 224WD 4Add BLAST40
Repeati371 – 413WD 5Add BLAST43

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00550000074968.
HOGENOMiHOG000183312.
InParanoidiQ04199.
KOiK10751.
OMAiQDGYCTL.
OrthoDBiEOG092C0UNU.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASHLQIYW HDSQPVYSLT FQKNSANDKL FTAGGDNKVR IWKLNRDENG
60 70 80 90 100
QNGGVRKIES LDFLGSLTHH EQAINVIRFN SKGDVLASAG DDGQVLLWKQ
110 120 130 140 150
EDPNTQQESV VRPFGMDAET SEADENKEKW VVWKRLRGGS GATAAAEIYD
160 170 180 190 200
LAWSPDNRNI VVACMDNSIR LFDVGAGMLV CGQSDHGHYV QGVAWDPLNQ
210 220 230 240 250
FILSQSADRS LHVYGVILSS AGVVTGLKLR SKIAKAELPC PGDVLRTNYL
260 270 280 290 300
FHNETLPSFF RRCSISPCGG LVVIPSGVYK VAGDEVANCV YVYTRSGILN
310 320 330 340 350
SAGGVKNRPA IRIPSLKKPA LMAAFSPVFY ETCQKSVLKL PYKLVFAIAT
360 370 380 390 400
TNEVLVYDTD VLEPLCVVGN IHYSPITDLA WSEDGSTLLI SSTDGFCSYV
410 420 430 440 450
SIDTETQFGS RIEPPAMHAE PLDTDESAVA AKNQREAGGI VNMLPVKKIP
460
CNSSDSKKRR IHPTPVDL
Length:468
Mass (Da):51,252
Last modified:November 1, 1997 - v1
Checksum:iF24853C4AA4D97C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80835 Genomic DNA. Translation: CAA56795.1.
BK006946 Genomic DNA. Translation: DAA09796.1.
PIRiS47447.
RefSeqiNP_013605.1. NM_001182464.1.

Genome annotation databases

EnsemblFungiiYML102W; YML102W; YML102W.
GeneIDi854869.
KEGGisce:YML102W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80835 Genomic DNA. Translation: CAA56795.1.
BK006946 Genomic DNA. Translation: DAA09796.1.
PIRiS47447.
RefSeqiNP_013605.1. NM_001182464.1.

3D structure databases

ProteinModelPortaliQ04199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35041. 119 interactors.
DIPiDIP-811N.
IntActiQ04199. 7 interactors.
MINTiMINT-552288.

Proteomic databases

MaxQBiQ04199.
PRIDEiQ04199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML102W; YML102W; YML102W.
GeneIDi854869.
KEGGisce:YML102W.

Organism-specific databases

EuPathDBiFungiDB:YML102W.
SGDiS000004570. CAC2.

Phylogenomic databases

GeneTreeiENSGT00550000074968.
HOGENOMiHOG000183312.
InParanoidiQ04199.
KOiK10751.
OMAiQDGYCTL.
OrthoDBiEOG092C0UNU.

Enzyme and pathway databases

BioCyciYEAST:G3O-32686-MONOMER.

Miscellaneous databases

PROiQ04199.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAC2_YEAST
AccessioniPrimary (citable) accession number: Q04199
Secondary accession number(s): D6W0I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.