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Protein

U3 small nucleolar RNA-associated protein 5

Gene

UTP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).2 Publications

GO - Biological processi

  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • positive regulation of transcription from RNA polymerase I promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-29945-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 5
Short name:
U3 snoRNA-associated protein 5
Alternative name(s):
U three protein 5
U3 protein 5 required for transcription
t-UTP5
Gene namesi
Name:UTP5
Ordered Locus Names:YDR398W
ORF Names:D9509.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR398W.
SGDiS000002806. UTP5.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • rDNA heterochromatin Source: SGD
  • small-subunit processome Source: SGD
  • t-UTP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643U3 small nucleolar RNA-associated protein 5PRO_0000051318Add
BLAST

Proteomic databases

MaxQBiQ04177.
PeptideAtlasiQ04177.

PTM databases

iPTMnetiQ04177.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.2 Publications

Protein-protein interaction databases

BioGridi32459. 37 interactions.
DIPiDIP-1317N.
IntActiQ04177. 13 interactions.
MINTiMINT-406050.

Structurei

3D structure databases

ProteinModelPortaliQ04177.
SMRiQ04177. Positions 231-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 5441WD 1Add
BLAST
Repeati55 – 9844WD 2Add
BLAST
Repeati186 – 22540WD 3Add
BLAST
Repeati227 – 26640WD 4Add
BLAST
Repeati340 – 38950WD 5Add
BLAST
Repeati471 – 51141WD 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi568 – 64376Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the UTP5 family.Curated
Contains 6 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000004254.
HOGENOMiHOG000246841.
InParanoidiQ04177.
KOiK14546.
OMAiGQYLCYV.
OrthoDBiEOG75J0WR.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04003. Utp12. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPVLQSAY DPSGQYLCYV TVALDKQRVG VQPTQRATSS GVDTVWNENF
60 70 80 90 100
LYLEDSKLKV TCLKWVNLAS SDTVAIILGM NNGEIWLYSV LANEVTYKFT
110 120 130 140 150
TGNSYEIKDI DLMGNQLWCI DSSDAFYQFD LLQFKLLQHF RINNCVQLNK
160 170 180 190 200
LTIVPAGDSV AQLLVASHSI SLIDIEEKKV VMTFPGHVSP VSTLQVITNE
210 220 230 240 250
FFISGAEGDR FLNVYDIHSG MTKCVLVAES DIKELSHSGQ ADSIAVTTED
260 270 280 290 300
GSLEIFVDPL VSSSTKKRGN KSKKSSKKIQ IVSKDGRKVP IYNAFINKDL
310 320 330 340 350
LNVSWLQNAT MPYFKNLQWR EIPNEYTVEI SLNWNNKNKS ADRDLHGKDL
360 370 380 390 400
ASATNYVEGN ARVTSGDNFK HVDDAIKSWE RELTSLEQEQ AKPPQANELL
410 420 430 440 450
TETFGDKLES STVARISGKK TNLKGSNLKT ATTTGTVTVI LSQALQSNDH
460 470 480 490 500
SLLETVLNNR DERVIRDTIF RLKPALAVIL LERLAERIAR QTHRQGPLNV
510 520 530 540 550
WVKWCLIIHG GYLVSIPNLM STLSSLHSTL KRRSDLLPRL LALDARLDCT
560 570 580 590 600
INKFKTLNYE AGDIHSSEPV VEEDEDDVEY NEELDDAGLI EDGEESYGSE
610 620 630 640
EEEEGDSDNE EEQKHTSSKQ DGRLETEQSD GEEEAGYSDV EME
Length:643
Mass (Da):72,002
Last modified:November 1, 1996 - v1
Checksum:i7A6F60C7C6F46C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32274 Genomic DNA. Translation: AAB64839.1.
BK006938 Genomic DNA. Translation: DAA12241.1.
PIRiS69681.
RefSeqiNP_010686.1. NM_001180706.1.

Genome annotation databases

EnsemblFungiiYDR398W; YDR398W; YDR398W.
GeneIDi852007.
KEGGisce:YDR398W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32274 Genomic DNA. Translation: AAB64839.1.
BK006938 Genomic DNA. Translation: DAA12241.1.
PIRiS69681.
RefSeqiNP_010686.1. NM_001180706.1.

3D structure databases

ProteinModelPortaliQ04177.
SMRiQ04177. Positions 231-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32459. 37 interactions.
DIPiDIP-1317N.
IntActiQ04177. 13 interactions.
MINTiMINT-406050.

PTM databases

iPTMnetiQ04177.

Proteomic databases

MaxQBiQ04177.
PeptideAtlasiQ04177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR398W; YDR398W; YDR398W.
GeneIDi852007.
KEGGisce:YDR398W.

Organism-specific databases

EuPathDBiFungiDB:YDR398W.
SGDiS000002806. UTP5.

Phylogenomic databases

GeneTreeiENSGT00390000004254.
HOGENOMiHOG000246841.
InParanoidiQ04177.
KOiK14546.
OMAiGQYLCYV.
OrthoDBiEOG75J0WR.

Enzyme and pathway databases

BioCyciYEAST:G3O-29945-MONOMER.

Miscellaneous databases

NextBioi970201.
PROiQ04177.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04003. Utp12. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
    Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
    Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUTP5_YEAST
AccessioniPrimary (citable) accession number: Q04177
Secondary accession number(s): D6VT31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 33100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.