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Q04164

- SAS_DROME

UniProt

Q04164 - SAS_DROME

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Protein
Putative epidermal cell surface receptor
Gene
sas, CG2507
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Vital for larval development.

GO - Molecular functioni

  1. receptor activity Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: FlyBase
  2. instar larval development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Putative epidermal cell surface receptor
Alternative name(s):
Stranded at second protein
Gene namesi
Name:sas
ORF Names:CG2507
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002306. sas.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 16351594Extracellular Reviewed prediction
Add
BLAST
Transmembranei1636 – 165621Helical; Reviewed prediction
Add
BLAST
Topological domaini1657 – 169337Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: FlyBase
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141 Reviewed prediction
Add
BLAST
Chaini42 – 16931652Putative epidermal cell surface receptor
PRO_0000022281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi473 – 4731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi685 – 6851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi827 – 8271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi846 – 8461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi929 – 9291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi939 – 9391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1323 – 13231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1419 – 14191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1517 – 15171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ04164.
PRIDEiQ04164.

Expressioni

Tissue specificityi

Expressed in most, if not all, ectodermal tissues which produce a cuticle.

Developmental stagei

Throughout development.

Gene expression databases

BgeeiQ04164.

Interactioni

Protein-protein interaction databases

BioGridi66056. 2 interactions.
DIPiDIP-23080N.
IntActiQ04164. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ04164.
SMRiQ04164. Positions 1344-1377, 1413-1484, 1516-1607.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini663 – 70846VWFC 1
Add
BLAST
Domaini828 – 90275VWFC 2
Add
BLAST
Domaini1281 – 1385105Fibronectin type-III 1
Add
BLAST
Domaini1407 – 1506100Fibronectin type-III 2
Add
BLAST
Domaini1512 – 160897Fibronectin type-III 3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 377327Thr-rich
Add
BLAST
Compositional biasi534 – 901368Cys-rich
Add
BLAST
Compositional biasi997 – 1273277Glu/Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 2 VWFC domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45538.
InParanoidiQ04164.
OMAiHILSENH.
OrthoDBiEOG7327NZ.
PhylomeDBiQ04164.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q04164-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQTCRRRKAS GGQSTIKWSR MCLATLCGLL LLGIQIERAA SAPAGEDAAA     50
TTMPPLDTTT DAPDAVAATT TPATTAAEQS SSISSITTEA ADGSTTSTTT 100
TTEAANKSNA TETDFTTNVP VASSLPEETS VRSTSIEPIT STEPTTTPRQ 150
ETEGPDQHMV FSNTEPDQSH IQHIPLRDEH AESSGADDAT TEMQRQREQD 200
QQQNELNQIS NEQDDVVKDL NNFRHPATLI TASNSNSEEN VEIESDKQVE 250
TTTTAVPAAA TSTSTEATGT PPTGTPATST STVPNEREED PYHVHILSEN 300
HDRLAEHEDY QMLSTSTEES STTSTTSTTN STTESGIVAG IVVSQENKAT 350
AEPSTATEST SISTSTTTAA TAATSTTSRA RAMHMNDPED EAATTIMPDS 400
ESVPVINIVE GQHMLQQEDQ KDEEEEGVVK ESESSSTTEA STTTTEPSPF 450
VAFAGEGRSA GGGNDIELFL HHNGSTHEQL MDLSDVSMDG DQNEGSSKTE 500
SSTTSTTTTT AQPETEMPKI VEITASGDTM QRECLANNKS YKHGELMERD 550
CDERCTCNRG DWMCEPRCRG LSYPRGSQRS MANPNCLEKM VEEDECCRVM 600
ECSEPQLEPT VVATEGAAPS TNGTGESAVT LPTTDDEATP KPRTDCHYNS 650
GVYKFRERLE IGCEQICHCA EGGVMDCRPR CPERNHTRLD KCVYVKDPKD 700
VCCQLELCDV TLDDHEQQPT PLQSNNNEDP EEIDPFRFQE QARDAGGAKP 750
TCTFKGAEYD VGQQFRDGCD QLCICNEQGI HCAKLECPSN FGLDVQDPHC 800
IRWEPVPADF KPSPPNCCPE SMRCVDNGTC SYQGVQIENW SPVPANLTGC 850
DQHCYCENGR VECRAACPPV PALPPADLPC HPALARLLPI PDDECCKHWM 900
CAPQIPKIGG AGQDEETEAT STHSSIPANE TTTTTATANK STSIPSKVPQ 950
IKKDEEKRPP ASGAFYPTLD GKPPKSIGGL GIFEKPEKPE KAHKKVQHQQ 1000
QQHQQQEQQE QQQHQNDVIF DGDRTEEQEE PLPPNGGFVP FQFGQQHPHQ 1050
PHLGPYGFYN PVKPVYEDYN PYEPYDINPN GTPQGKPPPV PTSQSDLFNI 1100
LGAEQPGHPV HPGHGGPPRI HPGQTQKDNH NLGPQVRIEQ ILQHLQQTVP 1150
GGPPPPPPHQ QHQSLTPQLH PQQQQISQQH PGHYVPIVHS GVPPPPPGHG 1200
IAIVDGQTVA YESYPVIPGL GVPQHHPQQH QTTPQQHLQQ TILPSSSTTS 1250
GLSTQASEHS LHQNQGKLAK QQQSGANNLQ PDIEVHTLEA IDPRSIRIVF 1300
TVPQVYVNLH GRVELRYSNG PSNDTSTWEQ QIFAPPEDLI ATSQMEFDLP 1350
SLEPNSLYKV KITLILRDLN SQPTSSIYTV KTPPERTITP PPPFPDYRPD 1400
FQDIFKNVED PELTVSETNA SWLQLTWKKL GDDQMEYVDG VQLRYKELTG 1450
MIYSSTPLIH RTLTSYTIQN LQPDTGYEIG LYYIPLAGHG AELRAGHMIK 1500
VRTAQKVDVY GFDVTVNVTK VKTQSVEISW NGVPYPEDKF VHIYRAIYQS 1550
DAGKEDSSVF KVAKRDSTTG TLIMDLKPGT KYRLWLEMYL TNGNTKKSNV 1600
VNFITKPGGP ATPGKTGKLL TAGTDQPVGD YYGPLVVVSV IAALAIMSTL 1650
ALLLIITRRR VHQTASITPP RKSDAAYDNP SYKVEIQQET MNL 1693
Length:1,693
Mass (Da):185,254
Last modified:November 15, 2002 - v2
Checksum:iDA50F96677F41DC4
GO
Isoform Short (identifier: Q04164-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     930-1274: Missing.

Show »
Length:1,348
Mass (Da):147,280
Checksum:i66416CA86B7FEC97
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei930 – 1274345Missing in isoform Short.
VSP_004071Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti591 – 5911V → L in AAA28879. 1 Publication
Sequence conflicti1509 – 15091V → G in AAA28879. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68866 mRNA. Translation: AAA28879.1.
AE014297 Genomic DNA. Translation: AAN13346.1.
AE014297 Genomic DNA. Translation: AAF54052.2.
AY051979 mRNA. Translation: AAK93403.1.
RefSeqiNP_001262336.1. NM_001275407.1. [Q04164-2]
NP_001262337.1. NM_001275408.1. [Q04164-1]
NP_476611.1. NM_057263.4. [Q04164-2]
NP_731141.1. NM_169177.2. [Q04164-1]
UniGeneiDm.1085.

Genome annotation databases

EnsemblMetazoaiFBtr0081570; FBpp0081089; FBgn0002306. [Q04164-1]
GeneIDi40861.
KEGGidme:Dmel_CG2507.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68866 mRNA. Translation: AAA28879.1 .
AE014297 Genomic DNA. Translation: AAN13346.1 .
AE014297 Genomic DNA. Translation: AAF54052.2 .
AY051979 mRNA. Translation: AAK93403.1 .
RefSeqi NP_001262336.1. NM_001275407.1. [Q04164-2 ]
NP_001262337.1. NM_001275408.1. [Q04164-1 ]
NP_476611.1. NM_057263.4. [Q04164-2 ]
NP_731141.1. NM_169177.2. [Q04164-1 ]
UniGenei Dm.1085.

3D structure databases

ProteinModelPortali Q04164.
SMRi Q04164. Positions 1344-1377, 1413-1484, 1516-1607.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66056. 2 interactions.
DIPi DIP-23080N.
IntActi Q04164. 1 interaction.

Proteomic databases

PaxDbi Q04164.
PRIDEi Q04164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0081570 ; FBpp0081089 ; FBgn0002306 . [Q04164-1 ]
GeneIDi 40861.
KEGGi dme:Dmel_CG2507.

Organism-specific databases

CTDi 393251.
FlyBasei FBgn0002306. sas.

Phylogenomic databases

eggNOGi NOG45538.
InParanoidi Q04164.
OMAi HILSENH.
OrthoDBi EOG7327NZ.
PhylomeDBi Q04164.

Miscellaneous databases

GenomeRNAii 40861.
NextBioi 821008.

Gene expression databases

Bgeei Q04164.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 3 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development."
    Schonbaum C.P., Organ E.L., Qu S., Cavener D.R.
    Dev. Biol. 151:431-445(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiSAS_DROME
AccessioniPrimary (citable) accession number: Q04164
Secondary accession number(s): Q960M6, Q9VI73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi