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Q04164

- SAS_DROME

UniProt

Q04164 - SAS_DROME

Protein

Putative epidermal cell surface receptor

Gene

sas

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (15 Nov 2002)
      Previous versions | rss
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    Functioni

    Vital for larval development.

    GO - Molecular functioni

    1. receptor activity Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: FlyBase
    2. instar larval development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative epidermal cell surface receptor
    Alternative name(s):
    Stranded at second protein
    Gene namesi
    Name:sas
    ORF Names:CG2507
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0002306. sas.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: FlyBase
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Chaini42 – 16931652Putative epidermal cell surface receptorPRO_0000022281Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi685 – 6851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi846 – 8461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi939 – 9391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1323 – 13231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1419 – 14191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1517 – 15171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ04164.
    PRIDEiQ04164.

    Expressioni

    Tissue specificityi

    Expressed in most, if not all, ectodermal tissues which produce a cuticle.

    Developmental stagei

    Throughout development.

    Gene expression databases

    BgeeiQ04164.

    Interactioni

    Protein-protein interaction databases

    BioGridi66056. 2 interactions.
    DIPiDIP-23080N.
    IntActiQ04164. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04164.
    SMRiQ04164. Positions 1344-1377, 1413-1484, 1516-1607.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini42 – 16351594ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1657 – 169337CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1636 – 165621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini663 – 70846VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini828 – 90275VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1281 – 1385105Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1407 – 1506100Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1512 – 160897Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi51 – 377327Thr-richAdd
    BLAST
    Compositional biasi534 – 901368Cys-richAdd
    BLAST
    Compositional biasi997 – 1273277Glu/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45538.
    InParanoidiQ04164.
    OMAiHILSENH.
    OrthoDBiEOG7327NZ.
    PhylomeDBiQ04164.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 3 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q04164-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQTCRRRKAS GGQSTIKWSR MCLATLCGLL LLGIQIERAA SAPAGEDAAA     50
    TTMPPLDTTT DAPDAVAATT TPATTAAEQS SSISSITTEA ADGSTTSTTT 100
    TTEAANKSNA TETDFTTNVP VASSLPEETS VRSTSIEPIT STEPTTTPRQ 150
    ETEGPDQHMV FSNTEPDQSH IQHIPLRDEH AESSGADDAT TEMQRQREQD 200
    QQQNELNQIS NEQDDVVKDL NNFRHPATLI TASNSNSEEN VEIESDKQVE 250
    TTTTAVPAAA TSTSTEATGT PPTGTPATST STVPNEREED PYHVHILSEN 300
    HDRLAEHEDY QMLSTSTEES STTSTTSTTN STTESGIVAG IVVSQENKAT 350
    AEPSTATEST SISTSTTTAA TAATSTTSRA RAMHMNDPED EAATTIMPDS 400
    ESVPVINIVE GQHMLQQEDQ KDEEEEGVVK ESESSSTTEA STTTTEPSPF 450
    VAFAGEGRSA GGGNDIELFL HHNGSTHEQL MDLSDVSMDG DQNEGSSKTE 500
    SSTTSTTTTT AQPETEMPKI VEITASGDTM QRECLANNKS YKHGELMERD 550
    CDERCTCNRG DWMCEPRCRG LSYPRGSQRS MANPNCLEKM VEEDECCRVM 600
    ECSEPQLEPT VVATEGAAPS TNGTGESAVT LPTTDDEATP KPRTDCHYNS 650
    GVYKFRERLE IGCEQICHCA EGGVMDCRPR CPERNHTRLD KCVYVKDPKD 700
    VCCQLELCDV TLDDHEQQPT PLQSNNNEDP EEIDPFRFQE QARDAGGAKP 750
    TCTFKGAEYD VGQQFRDGCD QLCICNEQGI HCAKLECPSN FGLDVQDPHC 800
    IRWEPVPADF KPSPPNCCPE SMRCVDNGTC SYQGVQIENW SPVPANLTGC 850
    DQHCYCENGR VECRAACPPV PALPPADLPC HPALARLLPI PDDECCKHWM 900
    CAPQIPKIGG AGQDEETEAT STHSSIPANE TTTTTATANK STSIPSKVPQ 950
    IKKDEEKRPP ASGAFYPTLD GKPPKSIGGL GIFEKPEKPE KAHKKVQHQQ 1000
    QQHQQQEQQE QQQHQNDVIF DGDRTEEQEE PLPPNGGFVP FQFGQQHPHQ 1050
    PHLGPYGFYN PVKPVYEDYN PYEPYDINPN GTPQGKPPPV PTSQSDLFNI 1100
    LGAEQPGHPV HPGHGGPPRI HPGQTQKDNH NLGPQVRIEQ ILQHLQQTVP 1150
    GGPPPPPPHQ QHQSLTPQLH PQQQQISQQH PGHYVPIVHS GVPPPPPGHG 1200
    IAIVDGQTVA YESYPVIPGL GVPQHHPQQH QTTPQQHLQQ TILPSSSTTS 1250
    GLSTQASEHS LHQNQGKLAK QQQSGANNLQ PDIEVHTLEA IDPRSIRIVF 1300
    TVPQVYVNLH GRVELRYSNG PSNDTSTWEQ QIFAPPEDLI ATSQMEFDLP 1350
    SLEPNSLYKV KITLILRDLN SQPTSSIYTV KTPPERTITP PPPFPDYRPD 1400
    FQDIFKNVED PELTVSETNA SWLQLTWKKL GDDQMEYVDG VQLRYKELTG 1450
    MIYSSTPLIH RTLTSYTIQN LQPDTGYEIG LYYIPLAGHG AELRAGHMIK 1500
    VRTAQKVDVY GFDVTVNVTK VKTQSVEISW NGVPYPEDKF VHIYRAIYQS 1550
    DAGKEDSSVF KVAKRDSTTG TLIMDLKPGT KYRLWLEMYL TNGNTKKSNV 1600
    VNFITKPGGP ATPGKTGKLL TAGTDQPVGD YYGPLVVVSV IAALAIMSTL 1650
    ALLLIITRRR VHQTASITPP RKSDAAYDNP SYKVEIQQET MNL 1693
    Length:1,693
    Mass (Da):185,254
    Last modified:November 15, 2002 - v2
    Checksum:iDA50F96677F41DC4
    GO
    Isoform Short (identifier: Q04164-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         930-1274: Missing.

    Show »
    Length:1,348
    Mass (Da):147,280
    Checksum:i66416CA86B7FEC97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti591 – 5911V → L in AAA28879. (PubMed:1339334)Curated
    Sequence conflicti1509 – 15091V → G in AAA28879. (PubMed:1339334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei930 – 1274345Missing in isoform Short. 1 PublicationVSP_004071Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68866 mRNA. Translation: AAA28879.1.
    AE014297 Genomic DNA. Translation: AAN13346.1.
    AE014297 Genomic DNA. Translation: AAF54052.2.
    AY051979 mRNA. Translation: AAK93403.1.
    RefSeqiNP_001262336.1. NM_001275407.1. [Q04164-2]
    NP_001262337.1. NM_001275408.1. [Q04164-1]
    NP_476611.1. NM_057263.4. [Q04164-2]
    NP_731141.1. NM_169177.2. [Q04164-1]
    UniGeneiDm.1085.

    Genome annotation databases

    EnsemblMetazoaiFBtr0081570; FBpp0081089; FBgn0002306. [Q04164-1]
    GeneIDi40861.
    KEGGidme:Dmel_CG2507.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68866 mRNA. Translation: AAA28879.1 .
    AE014297 Genomic DNA. Translation: AAN13346.1 .
    AE014297 Genomic DNA. Translation: AAF54052.2 .
    AY051979 mRNA. Translation: AAK93403.1 .
    RefSeqi NP_001262336.1. NM_001275407.1. [Q04164-2 ]
    NP_001262337.1. NM_001275408.1. [Q04164-1 ]
    NP_476611.1. NM_057263.4. [Q04164-2 ]
    NP_731141.1. NM_169177.2. [Q04164-1 ]
    UniGenei Dm.1085.

    3D structure databases

    ProteinModelPortali Q04164.
    SMRi Q04164. Positions 1344-1377, 1413-1484, 1516-1607.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66056. 2 interactions.
    DIPi DIP-23080N.
    IntActi Q04164. 1 interaction.

    Proteomic databases

    PaxDbi Q04164.
    PRIDEi Q04164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0081570 ; FBpp0081089 ; FBgn0002306 . [Q04164-1 ]
    GeneIDi 40861.
    KEGGi dme:Dmel_CG2507.

    Organism-specific databases

    CTDi 393251.
    FlyBasei FBgn0002306. sas.

    Phylogenomic databases

    eggNOGi NOG45538.
    InParanoidi Q04164.
    OMAi HILSENH.
    OrthoDBi EOG7327NZ.
    PhylomeDBi Q04164.

    Miscellaneous databases

    GenomeRNAii 40861.
    NextBioi 821008.

    Gene expression databases

    Bgeei Q04164.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 3 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development."
      Schonbaum C.P., Organ E.L., Qu S., Cavener D.R.
      Dev. Biol. 151:431-445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiSAS_DROME
    AccessioniPrimary (citable) accession number: Q04164
    Secondary accession number(s): Q960M6, Q9VI73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 15, 2002
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3