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Q04164 (SAS_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative epidermal cell surface receptor
Alternative name(s):
Stranded at second protein
Gene names
Name:sas
ORF Names:CG2507
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length1693 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Vital for larval development.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed in most, if not all, ectodermal tissues which produce a cuticle.

Developmental stage

Throughout development.

Sequence similarities

Contains 1 fibronectin type-III domain.

Contains 2 VWFC domains.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
Receptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinstar larval development

Inferred from mutant phenotype Ref.1. Source: UniProtKB

   Cellular_componentapical plasma membrane

Non-traceable author statement PubMed 11740560. Source: FlyBase

integral to plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionreceptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q04164-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q04164-2)

The sequence of this isoform differs from the canonical sequence as follows:
     930-1274: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4141 Potential
Chain42 – 16931652Putative epidermal cell surface receptor
PRO_0000022281

Regions

Topological domain42 – 16351594Extracellular Potential
Transmembrane1636 – 165621Helical; Potential
Topological domain1657 – 169337Cytoplasmic Potential
Domain663 – 70846VWFC 1
Domain828 – 90275VWFC 2
Domain1411 – 150191Fibronectin type-III
Compositional bias51 – 377327Thr-rich
Compositional bias534 – 901368Cys-rich
Compositional bias997 – 1273277Glu/Pro-rich

Amino acid modifications

Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation4731N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential
Glycosylation6221N-linked (GlcNAc...) Potential
Glycosylation6851N-linked (GlcNAc...) Potential
Glycosylation8271N-linked (GlcNAc...) Potential
Glycosylation8461N-linked (GlcNAc...) Potential
Glycosylation9291N-linked (GlcNAc...) Potential
Glycosylation9391N-linked (GlcNAc...) Potential
Glycosylation13231N-linked (GlcNAc...) Potential
Glycosylation14191N-linked (GlcNAc...) Potential
Glycosylation15171N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence930 – 1274345Missing in isoform Short.
VSP_004071

Experimental info

Sequence conflict5911V → L in AAA28879. Ref.1
Sequence conflict15091V → G in AAA28879. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 15, 2002. Version 2.
Checksum: DA50F96677F41DC4

FASTA1,693185,254
        10         20         30         40         50         60 
MQTCRRRKAS GGQSTIKWSR MCLATLCGLL LLGIQIERAA SAPAGEDAAA TTMPPLDTTT 

        70         80         90        100        110        120 
DAPDAVAATT TPATTAAEQS SSISSITTEA ADGSTTSTTT TTEAANKSNA TETDFTTNVP 

       130        140        150        160        170        180 
VASSLPEETS VRSTSIEPIT STEPTTTPRQ ETEGPDQHMV FSNTEPDQSH IQHIPLRDEH 

       190        200        210        220        230        240 
AESSGADDAT TEMQRQREQD QQQNELNQIS NEQDDVVKDL NNFRHPATLI TASNSNSEEN 

       250        260        270        280        290        300 
VEIESDKQVE TTTTAVPAAA TSTSTEATGT PPTGTPATST STVPNEREED PYHVHILSEN 

       310        320        330        340        350        360 
HDRLAEHEDY QMLSTSTEES STTSTTSTTN STTESGIVAG IVVSQENKAT AEPSTATEST 

       370        380        390        400        410        420 
SISTSTTTAA TAATSTTSRA RAMHMNDPED EAATTIMPDS ESVPVINIVE GQHMLQQEDQ 

       430        440        450        460        470        480 
KDEEEEGVVK ESESSSTTEA STTTTEPSPF VAFAGEGRSA GGGNDIELFL HHNGSTHEQL 

       490        500        510        520        530        540 
MDLSDVSMDG DQNEGSSKTE SSTTSTTTTT AQPETEMPKI VEITASGDTM QRECLANNKS 

       550        560        570        580        590        600 
YKHGELMERD CDERCTCNRG DWMCEPRCRG LSYPRGSQRS MANPNCLEKM VEEDECCRVM 

       610        620        630        640        650        660 
ECSEPQLEPT VVATEGAAPS TNGTGESAVT LPTTDDEATP KPRTDCHYNS GVYKFRERLE 

       670        680        690        700        710        720 
IGCEQICHCA EGGVMDCRPR CPERNHTRLD KCVYVKDPKD VCCQLELCDV TLDDHEQQPT 

       730        740        750        760        770        780 
PLQSNNNEDP EEIDPFRFQE QARDAGGAKP TCTFKGAEYD VGQQFRDGCD QLCICNEQGI 

       790        800        810        820        830        840 
HCAKLECPSN FGLDVQDPHC IRWEPVPADF KPSPPNCCPE SMRCVDNGTC SYQGVQIENW 

       850        860        870        880        890        900 
SPVPANLTGC DQHCYCENGR VECRAACPPV PALPPADLPC HPALARLLPI PDDECCKHWM 

       910        920        930        940        950        960 
CAPQIPKIGG AGQDEETEAT STHSSIPANE TTTTTATANK STSIPSKVPQ IKKDEEKRPP 

       970        980        990       1000       1010       1020 
ASGAFYPTLD GKPPKSIGGL GIFEKPEKPE KAHKKVQHQQ QQHQQQEQQE QQQHQNDVIF 

      1030       1040       1050       1060       1070       1080 
DGDRTEEQEE PLPPNGGFVP FQFGQQHPHQ PHLGPYGFYN PVKPVYEDYN PYEPYDINPN 

      1090       1100       1110       1120       1130       1140 
GTPQGKPPPV PTSQSDLFNI LGAEQPGHPV HPGHGGPPRI HPGQTQKDNH NLGPQVRIEQ 

      1150       1160       1170       1180       1190       1200 
ILQHLQQTVP GGPPPPPPHQ QHQSLTPQLH PQQQQISQQH PGHYVPIVHS GVPPPPPGHG 

      1210       1220       1230       1240       1250       1260 
IAIVDGQTVA YESYPVIPGL GVPQHHPQQH QTTPQQHLQQ TILPSSSTTS GLSTQASEHS 

      1270       1280       1290       1300       1310       1320 
LHQNQGKLAK QQQSGANNLQ PDIEVHTLEA IDPRSIRIVF TVPQVYVNLH GRVELRYSNG 

      1330       1340       1350       1360       1370       1380 
PSNDTSTWEQ QIFAPPEDLI ATSQMEFDLP SLEPNSLYKV KITLILRDLN SQPTSSIYTV 

      1390       1400       1410       1420       1430       1440 
KTPPERTITP PPPFPDYRPD FQDIFKNVED PELTVSETNA SWLQLTWKKL GDDQMEYVDG 

      1450       1460       1470       1480       1490       1500 
VQLRYKELTG MIYSSTPLIH RTLTSYTIQN LQPDTGYEIG LYYIPLAGHG AELRAGHMIK 

      1510       1520       1530       1540       1550       1560 
VRTAQKVDVY GFDVTVNVTK VKTQSVEISW NGVPYPEDKF VHIYRAIYQS DAGKEDSSVF 

      1570       1580       1590       1600       1610       1620 
KVAKRDSTTG TLIMDLKPGT KYRLWLEMYL TNGNTKKSNV VNFITKPGGP ATPGKTGKLL 

      1630       1640       1650       1660       1670       1680 
TAGTDQPVGD YYGPLVVVSV IAALAIMSTL ALLLIITRRR VHQTASITPP RKSDAAYDNP 

      1690 
SYKVEIQQET MNL

« Hide

Isoform Short [UniParc].

Checksum: 66416CA86B7FEC97
Show »

FASTA1,348147,280

References

« Hide 'large scale' references
[1]"The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development."
Schonbaum C.P., Organ E.L., Qu S., Cavener D.R.
Dev. Biol. 151:431-445(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
Strain: Berkeley.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M68866 mRNA. Translation: AAA28879.1.
AE014297 Genomic DNA. Translation: AAN13346.1.
AE014297 Genomic DNA. Translation: AAF54052.2.
AY051979 mRNA. Translation: AAK93403.1.
RefSeqNP_001262336.1. NM_001275407.1.
NP_001262337.1. NM_001275408.1.
NP_476611.1. NM_057263.4.
NP_731141.1. NM_169177.2.
UniGeneDm.1085.

3D structure databases

ProteinModelPortalQ04164.
SMRQ04164. Positions 1567-1593.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-23080N.
IntActQ04164. 1 interaction.
MINTMINT-344850.

Proteomic databases

PaxDbQ04164.
PRIDEQ04164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0081570; FBpp0081089; FBgn0002306.
GeneID40861.
KEGGdme:Dmel_CG2507.

Organism-specific databases

CTD393251.
FlyBaseFBgn0002306. sas.

Phylogenomic databases

eggNOGNOG45538.
GeneTreeENSGT00690000103233.
InParanoidQ04164.
OMAHILSENH.
OrthoDBEOG4J6Q5S.
PhylomeDBQ04164.

Gene expression databases

BgeeQ04164.
GermOnlineCG2507. Drosophila melanogaster.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001007. VWF_C.
[Graphical view]
PfamPF00041. fn3. 2 hits.
[Graphical view]
SMARTSM00060. FN3. 3 hits.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 2 hits.
PROSITEPS50853. FN3. 3 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi40861.
NextBio821008.

Entry information

Entry nameSAS_DROME
AccessionPrimary (citable) accession number: Q04164
Secondary accession number(s): Q960M6, Q9VI73
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents