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Protein

Putative epidermal cell surface receptor

Gene

sas

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Vital for larval development.

GO - Molecular functioni

  • receptor activity Source: UniProtKB

GO - Biological processi

  • axon guidance Source: FlyBase
  • instar larval development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Putative epidermal cell surface receptor
Alternative name(s):
Stranded at second protein
Gene namesi
Name:sas
ORF Names:CG2507
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002306. sas.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 1635ExtracellularSequence analysisAdd BLAST1594
Transmembranei1636 – 1656HelicalSequence analysisAdd BLAST21
Topological domaini1657 – 1693CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • apical plasma membrane Source: FlyBase
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000002228142 – 1693Putative epidermal cell surface receptorAdd BLAST1652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1
Glycosylationi538N-linked (GlcNAc...)Sequence analysis1
Glycosylationi622N-linked (GlcNAc...)Sequence analysis1
Glycosylationi685N-linked (GlcNAc...)Sequence analysis1
Glycosylationi827N-linked (GlcNAc...)Sequence analysis1
Glycosylationi846N-linked (GlcNAc...)Sequence analysis1
Glycosylationi929N-linked (GlcNAc...)Sequence analysis1
Glycosylationi939N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1323N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1517N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ04164.
PRIDEiQ04164.

Expressioni

Tissue specificityi

Expressed in most, if not all, ectodermal tissues which produce a cuticle.

Developmental stagei

Throughout development.

Gene expression databases

BgeeiFBgn0002306.
ExpressionAtlasiQ04164. baseline.
GenevisibleiQ04164. DM.

Interactioni

Protein-protein interaction databases

BioGridi66056. 2 interactors.
DIPiDIP-23080N.
STRINGi7227.FBpp0081089.

Structurei

3D structure databases

ProteinModelPortaliQ04164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini663 – 708VWFC 1PROSITE-ProRule annotationAdd BLAST46
Domaini828 – 902VWFC 2PROSITE-ProRule annotationAdd BLAST75
Domaini1281 – 1385Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST105
Domaini1407 – 1506Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini1512 – 1608Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 377Thr-richAdd BLAST327
Compositional biasi534 – 901Cys-richAdd BLAST368
Compositional biasi997 – 1273Glu/Pro-richAdd BLAST277

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG0Y. Eukaryota.
ENOG410YSW1. LUCA.
InParanoidiQ04164.
OMAiHCYCENG.
OrthoDBiEOG091G043S.
PhylomeDBiQ04164.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00214. VWC. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q04164-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTCRRRKAS GGQSTIKWSR MCLATLCGLL LLGIQIERAA SAPAGEDAAA
60 70 80 90 100
TTMPPLDTTT DAPDAVAATT TPATTAAEQS SSISSITTEA ADGSTTSTTT
110 120 130 140 150
TTEAANKSNA TETDFTTNVP VASSLPEETS VRSTSIEPIT STEPTTTPRQ
160 170 180 190 200
ETEGPDQHMV FSNTEPDQSH IQHIPLRDEH AESSGADDAT TEMQRQREQD
210 220 230 240 250
QQQNELNQIS NEQDDVVKDL NNFRHPATLI TASNSNSEEN VEIESDKQVE
260 270 280 290 300
TTTTAVPAAA TSTSTEATGT PPTGTPATST STVPNEREED PYHVHILSEN
310 320 330 340 350
HDRLAEHEDY QMLSTSTEES STTSTTSTTN STTESGIVAG IVVSQENKAT
360 370 380 390 400
AEPSTATEST SISTSTTTAA TAATSTTSRA RAMHMNDPED EAATTIMPDS
410 420 430 440 450
ESVPVINIVE GQHMLQQEDQ KDEEEEGVVK ESESSSTTEA STTTTEPSPF
460 470 480 490 500
VAFAGEGRSA GGGNDIELFL HHNGSTHEQL MDLSDVSMDG DQNEGSSKTE
510 520 530 540 550
SSTTSTTTTT AQPETEMPKI VEITASGDTM QRECLANNKS YKHGELMERD
560 570 580 590 600
CDERCTCNRG DWMCEPRCRG LSYPRGSQRS MANPNCLEKM VEEDECCRVM
610 620 630 640 650
ECSEPQLEPT VVATEGAAPS TNGTGESAVT LPTTDDEATP KPRTDCHYNS
660 670 680 690 700
GVYKFRERLE IGCEQICHCA EGGVMDCRPR CPERNHTRLD KCVYVKDPKD
710 720 730 740 750
VCCQLELCDV TLDDHEQQPT PLQSNNNEDP EEIDPFRFQE QARDAGGAKP
760 770 780 790 800
TCTFKGAEYD VGQQFRDGCD QLCICNEQGI HCAKLECPSN FGLDVQDPHC
810 820 830 840 850
IRWEPVPADF KPSPPNCCPE SMRCVDNGTC SYQGVQIENW SPVPANLTGC
860 870 880 890 900
DQHCYCENGR VECRAACPPV PALPPADLPC HPALARLLPI PDDECCKHWM
910 920 930 940 950
CAPQIPKIGG AGQDEETEAT STHSSIPANE TTTTTATANK STSIPSKVPQ
960 970 980 990 1000
IKKDEEKRPP ASGAFYPTLD GKPPKSIGGL GIFEKPEKPE KAHKKVQHQQ
1010 1020 1030 1040 1050
QQHQQQEQQE QQQHQNDVIF DGDRTEEQEE PLPPNGGFVP FQFGQQHPHQ
1060 1070 1080 1090 1100
PHLGPYGFYN PVKPVYEDYN PYEPYDINPN GTPQGKPPPV PTSQSDLFNI
1110 1120 1130 1140 1150
LGAEQPGHPV HPGHGGPPRI HPGQTQKDNH NLGPQVRIEQ ILQHLQQTVP
1160 1170 1180 1190 1200
GGPPPPPPHQ QHQSLTPQLH PQQQQISQQH PGHYVPIVHS GVPPPPPGHG
1210 1220 1230 1240 1250
IAIVDGQTVA YESYPVIPGL GVPQHHPQQH QTTPQQHLQQ TILPSSSTTS
1260 1270 1280 1290 1300
GLSTQASEHS LHQNQGKLAK QQQSGANNLQ PDIEVHTLEA IDPRSIRIVF
1310 1320 1330 1340 1350
TVPQVYVNLH GRVELRYSNG PSNDTSTWEQ QIFAPPEDLI ATSQMEFDLP
1360 1370 1380 1390 1400
SLEPNSLYKV KITLILRDLN SQPTSSIYTV KTPPERTITP PPPFPDYRPD
1410 1420 1430 1440 1450
FQDIFKNVED PELTVSETNA SWLQLTWKKL GDDQMEYVDG VQLRYKELTG
1460 1470 1480 1490 1500
MIYSSTPLIH RTLTSYTIQN LQPDTGYEIG LYYIPLAGHG AELRAGHMIK
1510 1520 1530 1540 1550
VRTAQKVDVY GFDVTVNVTK VKTQSVEISW NGVPYPEDKF VHIYRAIYQS
1560 1570 1580 1590 1600
DAGKEDSSVF KVAKRDSTTG TLIMDLKPGT KYRLWLEMYL TNGNTKKSNV
1610 1620 1630 1640 1650
VNFITKPGGP ATPGKTGKLL TAGTDQPVGD YYGPLVVVSV IAALAIMSTL
1660 1670 1680 1690
ALLLIITRRR VHQTASITPP RKSDAAYDNP SYKVEIQQET MNL
Length:1,693
Mass (Da):185,254
Last modified:November 15, 2002 - v2
Checksum:iDA50F96677F41DC4
GO
Isoform Short (identifier: Q04164-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     930-1274: Missing.

Show »
Length:1,348
Mass (Da):147,280
Checksum:i66416CA86B7FEC97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti591V → L in AAA28879 (PubMed:1339334).Curated1
Sequence conflicti1509V → G in AAA28879 (PubMed:1339334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004071930 – 1274Missing in isoform Short. 1 PublicationAdd BLAST345

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68866 mRNA. Translation: AAA28879.1.
AE014297 Genomic DNA. Translation: AAN13346.1.
AE014297 Genomic DNA. Translation: AAF54052.2.
AY051979 mRNA. Translation: AAK93403.1.
RefSeqiNP_001262336.1. NM_001275407.2. [Q04164-2]
NP_001262337.1. NM_001275408.2. [Q04164-1]
NP_476611.1. NM_057263.5. [Q04164-2]
NP_731141.1. NM_169177.3. [Q04164-1]
UniGeneiDm.1085.

Genome annotation databases

EnsemblMetazoaiFBtr0081570; FBpp0081089; FBgn0002306. [Q04164-1]
FBtr0334885; FBpp0306906; FBgn0002306. [Q04164-1]
GeneIDi40861.
KEGGidme:Dmel_CG2507.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68866 mRNA. Translation: AAA28879.1.
AE014297 Genomic DNA. Translation: AAN13346.1.
AE014297 Genomic DNA. Translation: AAF54052.2.
AY051979 mRNA. Translation: AAK93403.1.
RefSeqiNP_001262336.1. NM_001275407.2. [Q04164-2]
NP_001262337.1. NM_001275408.2. [Q04164-1]
NP_476611.1. NM_057263.5. [Q04164-2]
NP_731141.1. NM_169177.3. [Q04164-1]
UniGeneiDm.1085.

3D structure databases

ProteinModelPortaliQ04164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66056. 2 interactors.
DIPiDIP-23080N.
STRINGi7227.FBpp0081089.

Proteomic databases

PaxDbiQ04164.
PRIDEiQ04164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081570; FBpp0081089; FBgn0002306. [Q04164-1]
FBtr0334885; FBpp0306906; FBgn0002306. [Q04164-1]
GeneIDi40861.
KEGGidme:Dmel_CG2507.

Organism-specific databases

CTDi40861.
FlyBaseiFBgn0002306. sas.

Phylogenomic databases

eggNOGiENOG410IG0Y. Eukaryota.
ENOG410YSW1. LUCA.
InParanoidiQ04164.
OMAiHCYCENG.
OrthoDBiEOG091G043S.
PhylomeDBiQ04164.

Miscellaneous databases

GenomeRNAii40861.
PROiQ04164.

Gene expression databases

BgeeiFBgn0002306.
ExpressionAtlasiQ04164. baseline.
GenevisibleiQ04164. DM.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00214. VWC. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAS_DROME
AccessioniPrimary (citable) accession number: Q04164
Secondary accession number(s): Q960M6, Q9VI73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.