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Protein

Monopolin complex subunit LRS4

Gene

LRS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.3 Publications

Miscellaneous

Present with 1390 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: SGD
  • chromatin silencing at rDNA Source: SGD
  • homologous chromosome segregation Source: SGD
  • protein localization to nucleolar rDNA repeats Source: SGD
  • rDNA condensation Source: SGD
  • replication-born double-strand break repair via sister chromatid exchange Source: SGD

Keywordsi

Biological processCell cycle, Meiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29973-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Monopolin complex subunit LRS4
Alternative name(s):
Loss of rDNA silencing protein 4
Gene namesi
Name:LRS4
Ordered Locus Names:YDR439W
ORF Names:D9461.25
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR439W
SGDiS000002847 LRS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002578081 – 347Monopolin complex subunit LRS4Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDC5. This phosphorylation is required for the location to the kinetochores during late pachytene.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04087
PaxDbiQ04087
PRIDEiQ04087

PTM databases

CarbonylDBiQ04087
iPTMnetiQ04087

Interactioni

Subunit structurei

Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32495, 446 interactors
DIPiDIP-1416N
IntActiQ04087, 16 interactors
MINTiQ04087
STRINGi4932.YDR439W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N7NX-ray3.90E/F1-102[»]
ProteinModelPortaliQ04087
SMRiQ04087
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04087

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili46 – 118Sequence analysisAdd BLAST73

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ04087
KOiK12775
OMAiMAHENER
OrthoDBiEOG092C5W0M

Family and domain databases

InterProiView protein in InterPro
IPR018479 Lrs4/Mde4
PfamiView protein in Pfam
PF10422 LRS4, 1 hit

Sequencei

Sequence statusi: Complete.

Q04087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLLQLLSN YYKAKLDSER IYNEYVQSQY EFASLDKLNN NKGDPKKVVD
60 70 80 90 100
ETLFLQRQIA QLNKQLQLSF QENEKLLSVQ KNQKALYQSK LSSKDAFIDD
110 120 130 140 150
LKLKLKVEQI SVDKHNKERT PSTGRDEQQR NSKAAHTSKP TIHLLSPIVN
160 170 180 190 200
RDKPNNQTND RGGNDPDSPT SQRRSRGLRS LLSSGKNTIF DSISKNLDDE
210 220 230 240 250
INENAHIRND TTSSKIAGKS PSRLSALQKS PELRKERNNM ILKEHILRSK
260 270 280 290 300
DDQNITSSRK LDNIELSSIG DSTAMTSRSS TVNANDILGN EENDGITKLK
310 320 330 340
RVNKLTSSPV KRDCSTNKKR KLTKQRIATL PNSDEELSNN LNVDEFV
Length:347
Mass (Da):39,354
Last modified:November 1, 1996 - v1
Checksum:i60D880BA947B9005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA Translation: AAB64867.1
BK006938 Genomic DNA Translation: DAA12276.1
PIRiS69719
RefSeqiNP_010727.1, NM_001180747.1

Genome annotation databases

EnsemblFungiiYDR439W; YDR439W; YDR439W
GeneIDi852049
KEGGisce:YDR439W

Similar proteinsi

Entry informationi

Entry nameiLRS4_YEAST
AccessioniPrimary (citable) accession number: Q04087
Secondary accession number(s): D6VT66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health