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Protein

Monopolin complex subunit LRS4

Gene

LRS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.3 Publications

GO - Biological processi

  • chromatin silencing at rDNA Source: SGD
  • homologous chromosome segregation Source: SGD
  • protein localization to nucleolar rDNA repeats Source: SGD
  • rDNA condensation Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Meiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Monopolin complex subunit LRS4
Alternative name(s):
Loss of rDNA silencing protein 4
Gene namesi
Name:LRS4
Ordered Locus Names:YDR439W
ORF Names:D9461.25
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR439W.
SGDiS000002847. LRS4.

Subcellular locationi

  • Nucleusnucleolus
  • Chromosomecentromere

  • Note: Transiently released from the nucleolus and localized to the centromere regions during late pachytene. This relocation is CDC5 dependent.

GO - Cellular componenti

  • monopolin complex Source: SGD
  • nucleolus Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002578081 – 347Monopolin complex subunit LRS4Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDC5. This phosphorylation is required for the location to the kinetochores during late pachytene.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04087.
PRIDEiQ04087.

PTM databases

iPTMnetiQ04087.

Interactioni

Subunit structurei

Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC5P325626EBI-32189,EBI-4440
CDC7P062435EBI-32189,EBI-4451
CSM1P2565116EBI-32189,EBI-22001

Protein-protein interaction databases

BioGridi32495. 357 interactors.
DIPiDIP-1416N.
IntActiQ04087. 14 interactors.
MINTiMINT-391498.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N7NX-ray3.90E/F1-102[»]
ProteinModelPortaliQ04087.
SMRiQ04087.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04087.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili46 – 118Sequence analysisAdd BLAST73

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ04087.
KOiK12775.
OMAiMAHENER.
OrthoDBiEOG092C5W0M.

Family and domain databases

InterProiIPR018479. Lrs4/Mde4.
[Graphical view]
PfamiPF10422. LRS4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLLQLLSN YYKAKLDSER IYNEYVQSQY EFASLDKLNN NKGDPKKVVD
60 70 80 90 100
ETLFLQRQIA QLNKQLQLSF QENEKLLSVQ KNQKALYQSK LSSKDAFIDD
110 120 130 140 150
LKLKLKVEQI SVDKHNKERT PSTGRDEQQR NSKAAHTSKP TIHLLSPIVN
160 170 180 190 200
RDKPNNQTND RGGNDPDSPT SQRRSRGLRS LLSSGKNTIF DSISKNLDDE
210 220 230 240 250
INENAHIRND TTSSKIAGKS PSRLSALQKS PELRKERNNM ILKEHILRSK
260 270 280 290 300
DDQNITSSRK LDNIELSSIG DSTAMTSRSS TVNANDILGN EENDGITKLK
310 320 330 340
RVNKLTSSPV KRDCSTNKKR KLTKQRIATL PNSDEELSNN LNVDEFV
Length:347
Mass (Da):39,354
Last modified:November 1, 1996 - v1
Checksum:i60D880BA947B9005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA. Translation: AAB64867.1.
BK006938 Genomic DNA. Translation: DAA12276.1.
PIRiS69719.
RefSeqiNP_010727.1. NM_001180747.1.

Genome annotation databases

EnsemblFungiiYDR439W; YDR439W; YDR439W.
GeneIDi852049.
KEGGisce:YDR439W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA. Translation: AAB64867.1.
BK006938 Genomic DNA. Translation: DAA12276.1.
PIRiS69719.
RefSeqiNP_010727.1. NM_001180747.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N7NX-ray3.90E/F1-102[»]
ProteinModelPortaliQ04087.
SMRiQ04087.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32495. 357 interactors.
DIPiDIP-1416N.
IntActiQ04087. 14 interactors.
MINTiMINT-391498.

PTM databases

iPTMnetiQ04087.

Proteomic databases

MaxQBiQ04087.
PRIDEiQ04087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR439W; YDR439W; YDR439W.
GeneIDi852049.
KEGGisce:YDR439W.

Organism-specific databases

EuPathDBiFungiDB:YDR439W.
SGDiS000002847. LRS4.

Phylogenomic databases

InParanoidiQ04087.
KOiK12775.
OMAiMAHENER.
OrthoDBiEOG092C5W0M.

Enzyme and pathway databases

BioCyciYEAST:G3O-29973-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ04087.
PROiQ04087.

Family and domain databases

InterProiIPR018479. Lrs4/Mde4.
[Graphical view]
PfamiPF10422. LRS4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRS4_YEAST
AccessioniPrimary (citable) accession number: Q04087
Secondary accession number(s): D6VT66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1390 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.