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Protein

Sorting nexin-41

Gene

SNX41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in proper sorting of the v-SNARE protein SNC1.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei153 – 1531Phosphatidylinositol 3-phosphateBy similarity
Binding sitei155 – 1551Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei179 – 1791Phosphatidylinositol 3-phosphateBy similarity
Binding sitei202 – 2021Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD
  • phosphatidylinositol binding Source: SGD

GO - Biological processi

  • endocytosis Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: SGD
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29966-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-41
Gene namesi
Name:SNX41
Ordered Locus Names:YDR425W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR425W.
SGDiS000002833. SNX41.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • endosome Source: SGD
  • endosome membrane Source: UniProtKB-SubCell
  • extrinsic component of membrane Source: GO_Central
  • late endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625Sorting nexin-41PRO_0000213834Add
BLAST

Proteomic databases

MaxQBiQ04053.

PTM databases

iPTMnetiQ04053.

Interactioni

Subunit structurei

Binds to SNX4.

Binary interactionsi

WithEntry#Exp.IntActNotes
SNX4P470577EBI-30464,EBI-17610

Protein-protein interaction databases

BioGridi32484. 53 interactions.
DIPiDIP-3920N.
IntActiQ04053. 15 interactions.
MINTiMINT-486284.

Structurei

3D structure databases

ProteinModelPortaliQ04053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 235138PXPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili437 – 46933Sequence analysisAdd
BLAST
Coiled coili539 – 56325Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 8431Ser-richAdd
BLAST
Compositional biasi497 – 50812Ser-richAdd
BLAST

Domaini

The PX domain binds to phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the punctate structures.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00530000066389.
HOGENOMiHOG000142367.
InParanoidiQ04053.
OMAiGAYYNAF.
OrthoDBiEOG092C1RTM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYNIFEAVH EQQSSTSDMD LSEEDNNPFV GTHHLYASGI GTTIGEARPE
60 70 80 90 100
NENSPPSSSS LPSSPAHSSS AGSSRASTSS STSSHAVVEA DAETEPFVSL
110 120 130 140 150
SMSTTATISK FTPHDMNGTQ QIQIIDAGDF KDPWGKHAIG YVILYENNKI
160 170 180 190 200
IRRYSEFHSL RQSLTRLLPT IIIPPIPSKH SLLKYIWSPI NAANDSKIIS
210 220 230 240 250
TRKKMLNSFL SNCLNIQEIS NDIVFQKFLN PEFNWKDVLS SSPIIILPLN
260 270 280 290 300
NLLAPPLSPT KPSPLHSILP IPSNSSLRNY NSIWQQHITV KSHNEISNLP
310 320 330 340 350
TEILQNESQF THIENLFQNY KRIITHLLKN IRSNKSHFHS LSTYFAELGA
360 370 380 390 400
YYNAFSLEND ITMPNSLRES ENNSNNPMME IISHIEKTGH SFDVIYISSE
410 420 430 440 450
ILIEKYTSIL EDPINELLQF LNESFKVLNF KKLKFLQFKI LERLIIEKET
460 470 480 490 500
KLSSLTEIEN QLQKINESLT RSTILTDENY KDTKAADLTF VKKDVRSLSK
510 520 530 540 550
SSSNSSSSGH QNEIHIGASK LNYKTSTPTM NLNKLEIKQL TEQERSKQIK
560 570 580 590 600
QLNQDLSKLK DCLSICISDM LEINNSSYNS LMHTYNHINL TIGKILKLFA
610 620
ASFKAWIKEC LKNWKLAKLQ IDEAL
Length:625
Mass (Da):70,741
Last modified:November 1, 1996 - v1
Checksum:iB9A064EDE0C52085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA. Translation: AAB64858.1.
BK006938 Genomic DNA. Translation: DAA12265.1.
PIRiS69707.
RefSeqiNP_010713.1. NM_001180733.1.

Genome annotation databases

EnsemblFungiiYDR425W; YDR425W; YDR425W.
GeneIDi852035.
KEGGisce:YDR425W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA. Translation: AAB64858.1.
BK006938 Genomic DNA. Translation: DAA12265.1.
PIRiS69707.
RefSeqiNP_010713.1. NM_001180733.1.

3D structure databases

ProteinModelPortaliQ04053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32484. 53 interactions.
DIPiDIP-3920N.
IntActiQ04053. 15 interactions.
MINTiMINT-486284.

PTM databases

iPTMnetiQ04053.

Proteomic databases

MaxQBiQ04053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR425W; YDR425W; YDR425W.
GeneIDi852035.
KEGGisce:YDR425W.

Organism-specific databases

EuPathDBiFungiDB:YDR425W.
SGDiS000002833. SNX41.

Phylogenomic databases

GeneTreeiENSGT00530000066389.
HOGENOMiHOG000142367.
InParanoidiQ04053.
OMAiGAYYNAF.
OrthoDBiEOG092C1RTM.

Enzyme and pathway databases

BioCyciYEAST:G3O-29966-MONOMER.

Miscellaneous databases

PROiQ04053.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX41_YEAST
AccessioniPrimary (citable) accession number: Q04053
Secondary accession number(s): D6VT55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.