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Protein

Sorting nexin-41

Gene

SNX41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in proper sorting of the v-SNARE protein SNC1.1 Publication

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei153Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei155Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei179Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei202Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD
  • phosphatidylinositol binding Source: SGD

GO - Biological processi

  • endocytosis Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: SGD
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29966-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-41
Gene namesi
Name:SNX41
Ordered Locus Names:YDR425W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR425W
SGDiS000002833 SNX41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138341 – 625Sorting nexin-41Add BLAST625

Proteomic databases

MaxQBiQ04053
PaxDbiQ04053
PRIDEiQ04053

PTM databases

iPTMnetiQ04053

Interactioni

Subunit structurei

Binds to SNX4.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32484, 119 interactors
DIPiDIP-3920N
IntActiQ04053, 20 interactors
MINTiQ04053
STRINGi4932.YDR425W

Structurei

3D structure databases

ProteinModelPortaliQ04053
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 235PXPROSITE-ProRule annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili437 – 469Sequence analysisAdd BLAST33
Coiled coili539 – 563Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 84Ser-richAdd BLAST31
Compositional biasi497 – 508Ser-richAdd BLAST12

Domaini

The PX domain binds to phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the punctate structures.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00530000066389
HOGENOMiHOG000142367
InParanoidiQ04053
KOiK21996
OMAiPNYELCW
OrthoDBiEOG092C1RTM

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q04053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYNIFEAVH EQQSSTSDMD LSEEDNNPFV GTHHLYASGI GTTIGEARPE
60 70 80 90 100
NENSPPSSSS LPSSPAHSSS AGSSRASTSS STSSHAVVEA DAETEPFVSL
110 120 130 140 150
SMSTTATISK FTPHDMNGTQ QIQIIDAGDF KDPWGKHAIG YVILYENNKI
160 170 180 190 200
IRRYSEFHSL RQSLTRLLPT IIIPPIPSKH SLLKYIWSPI NAANDSKIIS
210 220 230 240 250
TRKKMLNSFL SNCLNIQEIS NDIVFQKFLN PEFNWKDVLS SSPIIILPLN
260 270 280 290 300
NLLAPPLSPT KPSPLHSILP IPSNSSLRNY NSIWQQHITV KSHNEISNLP
310 320 330 340 350
TEILQNESQF THIENLFQNY KRIITHLLKN IRSNKSHFHS LSTYFAELGA
360 370 380 390 400
YYNAFSLEND ITMPNSLRES ENNSNNPMME IISHIEKTGH SFDVIYISSE
410 420 430 440 450
ILIEKYTSIL EDPINELLQF LNESFKVLNF KKLKFLQFKI LERLIIEKET
460 470 480 490 500
KLSSLTEIEN QLQKINESLT RSTILTDENY KDTKAADLTF VKKDVRSLSK
510 520 530 540 550
SSSNSSSSGH QNEIHIGASK LNYKTSTPTM NLNKLEIKQL TEQERSKQIK
560 570 580 590 600
QLNQDLSKLK DCLSICISDM LEINNSSYNS LMHTYNHINL TIGKILKLFA
610 620
ASFKAWIKEC LKNWKLAKLQ IDEAL
Length:625
Mass (Da):70,741
Last modified:November 1, 1996 - v1
Checksum:iB9A064EDE0C52085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA Translation: AAB64858.1
BK006938 Genomic DNA Translation: DAA12265.1
PIRiS69707
RefSeqiNP_010713.1, NM_001180733.1

Genome annotation databases

EnsemblFungiiYDR425W; YDR425W; YDR425W
GeneIDi852035
KEGGisce:YDR425W

Similar proteinsi

Entry informationi

Entry nameiSNX41_YEAST
AccessioniPrimary (citable) accession number: Q04053
Secondary accession number(s): D6VT55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health