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Protein

Transcriptional activator ARO80

Gene

ARO80

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi25 – 5834Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Branched-chain amino acid catabolism, Phenylalanine catabolism, Transcription, Transcription regulation, Tryptophan catabolism, Tyrosine catabolism

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator ARO80
Gene namesi
Name:ARO80
Ordered Locus Names:YDR421W
ORF Names:D9461.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR421W.
SGDiS000002829. ARO80.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Transcriptional activator ARO80PRO_0000114938Add
BLAST

Proteomic databases

MaxQBiQ04052.
PRIDEiQ04052.

PTM databases

iPTMnetiQ04052.

Interactioni

Protein-protein interaction databases

BioGridi32480. 25 interactions.
DIPiDIP-1012N.
IntActiQ04052. 2 interactions.
MINTiMINT-605292.

Structurei

3D structure databases

ProteinModelPortaliQ04052.
SMRiQ04052. Positions 23-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi921 – 94323Asn-richAdd
BLAST

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000034058.
InParanoidiQ04052.
OMAiYMPVRWV.
OrthoDBiEOG092C0KB3.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKRPSGN AAFELPKRRR TYQACISCRS RKVKCDLGPV DNPHDPPCAR
60 70 80 90 100
CKRELKKCIF SSNKGTSNDL PPNSINAISL PSLGKSKQEI QNDSTSPILS
110 120 130 140 150
DVPLSRKGIS SEKSFKSEGM KWKLELSSMQ NALEFLAQAA GTVAKEGAKE
160 170 180 190 200
IIKEKSTTPK PLKSSLDATN KSATDEGLKR LSKSDSTNTL YENTADMLNH
210 220 230 240 250
TLNTNRKTSQ LMEEIGKVRP PPTRKIDDFD YIGPDSLLTK EEAIELIEAF
260 270 280 290 300
FLTMHPFFPN IPLQLHDPKE LAEYPILFCA ILTVSARYHP FDTLGLDNGE
310 320 330 340 350
DGMRHIEVHD KLWVYCQKLI SQTIWAEAST RSIGTVLAFI IFTEWNPRSI
360 370 380 390 400
HYKWSDYAND PELNNVNARG SKNISTRKDE EGLTGVGAIR RSDRMSWMLT
410 420 430 440 450
GSAVRLAQDM GFIENSSKVF IVTHISETTS AMNMNQRSLL AESFSVLNLN
460 470 480 490 500
LGKIENDGNE SNEDYLGNEK FYLNEILPDE ESKLRWKRVF ENSENDHDNE
510 520 530 540 550
KNFLTDWERE FLNDEYVLYY SNKKDDTNLA QNHIPPFPLR FSFAQRAKIE
560 570 580 590 600
IIRILSIAYE TIYCEKNKRK LATTDQRHNL SVLSVFSPLI EGWLSNYREL
610 620 630 640 650
LVPLSDVPFS LADRKNKKQI FDNIDRINGE SIITDFNYCQ LYIFSLALQV
660 670 680 690 700
DGKTSRLNMN EIVTSARYVE LAYRSAKEIL SSAKRVSRQG MLKYMPVRWV
710 720 730 740 750
IRIIRSIAFI VKCYLTLTGS ELATNPDARN ILKLSAISVD ETFDIIRDTA
760 770 780 790 800
VTLKEATPDE LHLCQRYAAI LMYLCTEMKL RKKSYLERPP LLRDGTTPLE
810 820 830 840 850
SNRESSLEGQ DLTKKPIFSK RIGYNKTETT FEPSERPLTE EINSNSQNSN
860 870 880 890 900
DTSSKGIVDP FVEQNNDITT ALLNNELFQG PSLSDEVTDW FGASEDIGLE
910 920 930 940 950
FVEPWTELIE QRYMQCGDGD NNNFENLYNL FVNSNNINND INNSRPITRK
Length:950
Mass (Da):108,205
Last modified:November 1, 1996 - v1
Checksum:i3F86083C127D32A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA. Translation: AAB64863.1.
BK006938 Genomic DNA. Translation: DAA12261.1.
PIRiS69704.
RefSeqiNP_010709.1. NM_001180729.1.

Genome annotation databases

EnsemblFungiiYDR421W; YDR421W; YDR421W.
GeneIDi852031.
KEGGisce:YDR421W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA. Translation: AAB64863.1.
BK006938 Genomic DNA. Translation: DAA12261.1.
PIRiS69704.
RefSeqiNP_010709.1. NM_001180729.1.

3D structure databases

ProteinModelPortaliQ04052.
SMRiQ04052. Positions 23-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32480. 25 interactions.
DIPiDIP-1012N.
IntActiQ04052. 2 interactions.
MINTiMINT-605292.

PTM databases

iPTMnetiQ04052.

Proteomic databases

MaxQBiQ04052.
PRIDEiQ04052.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR421W; YDR421W; YDR421W.
GeneIDi852031.
KEGGisce:YDR421W.

Organism-specific databases

EuPathDBiFungiDB:YDR421W.
SGDiS000002829. ARO80.

Phylogenomic databases

HOGENOMiHOG000034058.
InParanoidiQ04052.
OMAiYMPVRWV.
OrthoDBiEOG092C0KB3.

Enzyme and pathway databases

BioCyciYEAST:G3O-29962-MONOMER.

Miscellaneous databases

PROiQ04052.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARO80_YEAST
AccessioniPrimary (citable) accession number: Q04052
Secondary accession number(s): D6VT51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.