Q04005 (LIC4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ATC1/LIC4

Alternative name(s):
AIP3 complex protein 1
Lithium comvertas protein 4

Gene names

Name:	ATC1
Synonyms:	LIC4
Ordered Locus Names:	YDR184C
ORF Names:	YD9395.18c

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in cation homeostasis and in the regulation of the cation stress signaling cascades. Also involved in bipolar budding. Ref.4 Ref.5 Ref.8
Subcellular location	Cytoplasm. Nucleus. Note: The nuclear location is modulated by calcineurin. Ref.4 Ref.6
Miscellaneous	Present with 846 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bipolar cellular bud site selection Inferred from genetic interaction Ref.5. Source: SGD response to stress Inferred from genetic interaction Ref.4. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 22842922. Source: SGD nucleus Inferred from direct assay Ref.4PubMed 22842922. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Protein ATC1/LIC4		PRO_0000076239
Amino acid modifications
	Modified residue	167	1	Phosphoserine Ref.9
Experimental info
	Sequence conflict	204	1	S → P in AAS56902. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q04005 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4D33DCBEF0BFDF91	FASTA	294	33,114
	10 20 30 40 50 60 MNTNQSNPNT DLTDDANIEH TLHRLLTQAN NHFDDTVKID GQSLDLGKDL EQVMMDNLDC 70 80 90 100 110 120 TDIFDSDIAS QKHLTLESLF NDEHNTDSST LLEMQRSAND SLVGIDLDRH KKGYTGKASL 130 140 150 160 170 180 DKSTNQNNVH KPDKEQKNYK IDKPTIKKKK SLLKTTNEPM LSPASLSPSS SLASSDANES 190 200 210 220 230 240 HLKIESMITD ITSKIDSARQ DIVSATKPAK FTNEFTISQI SEMKARIINT HKLLLNFNFI 250 260 270 280 290 KEGYARSCIQ LKKSMDSLKD SEIHRAHLLV ENDDLKQQIL ELTQKLNEKS SKES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae." Hemenway C.S., Heitman J. Mol. Gen. Genet. 261:388-401(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
[5]	"Mutational and hyperexpression-induced disruption of bipolar budding in yeast." Freedman T., Porter A., Haarer B. Microbiology 146:2833-2843(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"ARL1 participates with ATC1/LIC4 to regulate responses of yeast cells to ions." Munson A.M., Love S.L., Shu J., Palanivel V.R., Rosenwald A.G. Biochem. Biophys. Res. Commun. 315:617-623(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46727 Genomic DNA. Translation: CAA86691.1. AY558576 Genomic DNA. Translation: AAS56902.1. BK006938 Genomic DNA. Translation: DAA12028.1.
PIR	S49781.
RefSeq	NP_010470.1. NM_001180492.1.
3D structure databases
ProteinModelPortal	Q04005.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-832N.
IntAct	Q04005. 4 interactions.
MINT	MINT-535572.
STRING	4932.YDR184C.
Proteomic databases
PaxDb	Q04005.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDR184C; YDR184C; YDR184C.
GeneID	851765.
KEGG	sce:YDR184C.
Organism-specific databases
CYGD	YDR184c.
SGD	S000002592. ATC1.
Phylogenomic databases
eggNOG	NOG41165.
OrthoDB	EOG44F9KX.
Gene expression databases
Genevestigator	Q04005.
GermOnline	YDR184C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	969549.

Entry information

Entry name

LIC4_YEAST

Accession

Primary (citable) accession number: Q04005
Secondary accession number(s): D6VSG8, Q6Q540

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program