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Q03ZT9 (UPPP_LEUMM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:LEUM_0133
OrganismLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]
Taxonomic identifier203120 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostoc

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence ABJ61283.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290722

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane228 – 24821Helical; Potential
Transmembrane259 – 27921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q03ZT9 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: F5534C8E855B7119

FASTA28131,301
        10         20         30         40         50         60 
MFDLIKAIII GIIEGLTEFL PVSSTGHIIL AEALMKIPSG NVWTKAFSSV FDYSIQLGAI 

        70         80         90        100        110        120 
FAVIQLYFDK LNPFSSKKTD HEKFQTWRLW IRVIVGVLPA IVFGFALNDF MDAHLMNFWV 

       130        140        150        160        170        180 
VSATLIIYGI AFIVIENRQK SIVPVITNVN QITFKLALYI GLFQVLSIVP GTSRSGATIL 

       190        200        210        220        230        240 
GAIILGASRF VAAEFSFFLS IPVMFGVTFL KMGSFFRDGG SFTGMQSIVM LVGFIVSWIV 

       250        260        270        280 
AWFAIKFMMN YIKNNDFKVF GYYRIIIGAI FLVFGILGIV G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000414 Genomic DNA. Translation: ABJ61283.1. Different initiation.
RefSeqYP_817656.1. NC_008531.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203120.LEUM_0133.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ61283; ABJ61283; LEUM_0133.
GeneID4422063.
KEGGlme:LEUM_0133.
PATRIC22408247. VBILeuMes50664_0161.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycLMES203120:GJ8T-133-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_LEUMM
AccessionPrimary (citable) accession number: Q03ZT9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families