Q03Z41 (HEMH_LEUMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase
EC=4.99.1.1

Alternative name(s):
Heme synthase
Protoheme ferro-lyase

Gene names

Name:	hemH
Ordered Locus Names:	LEUM_0412

Organism

Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]

Taxonomic identifier

203120 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Ferrochelatase HAMAP MF_00323		PRO_1000019317
Sites
	Metal binding	185	1	Iron By similarity
	Metal binding	267	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q03Z41 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: E9F3A2024CA6CA52	FASTA	315	36,114
	10 20 30 40 50 60 MNKKGLLLVN LGTPDSPHPD DVKAYLKEFL SDTNVIQMPR LLWQPILRGK ILPKRSFKSA 70 80 90 100 110 120 ELYQKIWRKD GSPLMVYAKK QVEQVQQLQP NWIVRCAMTY RKPNIAETLK EMRLAGADDI 130 140 150 160 170 180 VVLPLFPQYS VTSTQSVIDQ VRKADKNINI VKSFYNDEAY LDLLARDIRE AWAKNDYDRL 190 200 210 220 230 240 IISYHGVPES YVRRGDPYVD HCTATTQGVL ERVGPLTPDN THQVFQSRFG PTEWVKPYLS 250 260 270 280 290 300 DTLRSLPSQG IKRVLVATPA FVADCLETIE EIHVENHDIF KQAGGEVFDV VQPFNEHIDF 310 SKYIASLANR HFAQN

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8293 / NCDO 523.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000414 Genomic DNA. Translation: ABJ61531.1.
RefSeq	YP_817904.1. NC_008531.1.
3D structure databases
ProteinModelPortal	Q03Z41.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03Z41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4422296.
GenomeReviews	Gene locus LEUM_0412 in contig CP000414_GR.
KEGG	lme:LEUM_0412.
NMPDR	fig|203120.1.peg.1381.
PATRIC	22408811. VBILeuMes50664_0414.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0276.
HOGENOM	HBG697135.
OMA	TIEEIGM.
PhylomeDB	Q03Z41.
ProtClustDB	CLSK697807.
Enzyme and pathway databases
BioCyc	LMES203120:LEUM_0412-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_LEUMM

Accession

Primary (citable) accession number: Q03Z41

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program