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Q03YX1 (THIM1_LEUMM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase 1

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 1
Short name=TH kinase 1
Short name=Thz kinase 1
Gene names
Name:thiM1
Ordered Locus Names:LEUM_0485
OrganismLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]
Taxonomic identifier203120 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostoc

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Hydroxyethylthiazole kinase 1 HAMAP-Rule MF_00228
PRO_0000383881

Sites

Binding site381Substrate; via amide nitrogen By similarity
Binding site1131ATP By similarity
Binding site1581ATP By similarity
Binding site1851Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03YX1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 967ECB5AFE317221

FASTA25927,406
        10         20         30         40         50         60 
MNITDIRTKS PLVLTYANFV TPQFVANVVN VVGASPLMSR ELAEFKELAG IANAVIINTG 

        70         80         90        100        110        120 
TLQKVEINDI IKLSQEAYQL GKPVVLDPVA VSVPFRSKAI TQFLASGHVD VIRGNAAEIA 

       130        140        150        160        170        180 
WFADIDFASQ GIDATGKGDV IEIAQRAAKK TGAVIALSGA CDVVSDGQYT QTLDINVEQL 

       190        200        210        220        230        240 
SSIVGTGDAL SSLIGAFIAD GLKVPNVMNA MATFKLAGQK AATKTNQPGS FTNQLLDELF 

       250 
VIDNIDVQNF VKESVLNHG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000414 Genomic DNA. Translation: ABJ61601.1.
RefSeqYP_817974.1. NC_008531.1.

3D structure databases

ProteinModelPortalQ03YX1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203120.LEUM_0485.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ61601; ABJ61601; LEUM_0485.
GeneID4422352.
KEGGlme:LEUM_0485.
PATRIC22408957. VBILeuMes50664_0485.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBCLSK2318757.

Enzyme and pathway databases

BioCycLMES203120:GJ8T-485-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM1_LEUMM
AccessionPrimary (citable) accession number: Q03YX1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways