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Q03YH4

- SYL_LEUMM

UniProt

Q03YH4 - SYL_LEUMM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei583 – 5831ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMES203120:GJ8T-635-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LEUM_0635
    OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
    Taxonomic identifieri203120 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
    ProteomesiUP000000362: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 808808Leucine--tRNA ligasePRO_1000009366Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203120.LEUM_0635.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03YH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi580 – 5845"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03YH4-1 [UniParc]FASTAAdd to Basket

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    MAYDHKSIEA KWQKYWDEHE TFRAPDKSEK EKYYVMDMFP YPSGQGLHVG    50
    HPEGYTATDI MSRYKRAKGF NVLHPMGWDA FGLPAEQYAI KTGNNPAGFT 100
    NKNVQVFKNQ IKSLGFSIDW SREINTTDPE YYKWSQWIFE KLYEKGLAYE 150
    DEIMVNWAPD FPGGGIVVAN EEVIDGKTER GGYPVYRKPM KQWVLRITAY 200
    ADRLLEDLED LDWPEAIKEQ QRHWIGKSIG ASVFFNIADS DKQIEVYTTR 250
    PDTLFGAQYM VLSPEHELVD EITTLEQKEA IANYKKEVET KSDLERTDLN 300
    KDKTGAFTGA YATNPINGEK LPIWIADYVL SSYGTGAIMA VPAHDDRDWE 350
    FAKKFNLPIK AVIEGGNVEE AAYTDDGTHI NSGFLDGLNK QEAIDKAISW 400
    LEEHNAGHQQ INYRLRDWIF SRQRYWGEPI PVIHWEDGTQ TLVPESELPL 450
    RLPEMTQEQL KPSGTGESPL ANATDWLNVT RKDGVKGRRE TNTMPQWAGS 500
    SWYFLRYVDP HNSEALADPE KLKYWMNVDL YVGGAEHAVL HLLYARFWHK 550
    FLYDLGVVPT KEPFQKLVNQ GMILGENHEK MSKSKGNVVN PDEIVNNYGA 600
    DTLRVYEMFM GPLTQSKPWS EDGVSGSRRW LDRVWRLLVD EEDKLRDHVT 650
    TVNKGDLDKI YHQTVKKVSE DLENMRFNTA ISQLMVFVNE AYKSEALPVQ 700
    YMDGFVQMLA PIAPHLAEEL WSKLGHEEDI SYVSWPTYDE SQLVEDSVEI 750
    IFQVNGKVRG KATVARNIDK DAMLDYAKAD ENVQNFISGK EIRKIIAIPG 800
    KFVNIVVG 808
    Length:808
    Mass (Da):92,689
    Last modified:November 14, 2006 - v1
    Checksum:i437DB9D2DDD86F42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000414 Genomic DNA. Translation: ABJ61748.1.
    RefSeqiWP_011679445.1. NC_008531.1.
    YP_818121.1. NC_008531.1.

    Genome annotation databases

    EnsemblBacteriaiABJ61748; ABJ61748; LEUM_0635.
    GeneIDi4422468.
    KEGGilme:LEUM_0635.
    PATRICi22409255. VBILeuMes50664_0631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000414 Genomic DNA. Translation: ABJ61748.1 .
    RefSeqi WP_011679445.1. NC_008531.1.
    YP_818121.1. NC_008531.1.

    3D structure databases

    ProteinModelPortali Q03YH4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203120.LEUM_0635.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ61748 ; ABJ61748 ; LEUM_0635 .
    GeneIDi 4422468.
    KEGGi lme:LEUM_0635.
    PATRICi 22409255. VBILeuMes50664_0631.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LMES203120:GJ8T-635-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8293 / NCDO 523.

    Entry informationi

    Entry nameiSYL_LEUMM
    AccessioniPrimary (citable) accession number: Q03YH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3