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Q03YH4

- SYL_LEUMM

UniProt

Q03YH4 - SYL_LEUMM

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Protein

Leucine--tRNA ligase

Gene
leuS, LEUM_0635
Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMES203120:GJ8T-635-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:LEUM_0635
OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Taxonomic identifieri203120 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000000362: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Leucine--tRNA ligaseUniRule annotationPRO_1000009366Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203120.LEUM_0635.

Structurei

3D structure databases

ProteinModelPortaliQ03YH4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03YH4-1 [UniParc]FASTAAdd to Basket

« Hide

MAYDHKSIEA KWQKYWDEHE TFRAPDKSEK EKYYVMDMFP YPSGQGLHVG    50
HPEGYTATDI MSRYKRAKGF NVLHPMGWDA FGLPAEQYAI KTGNNPAGFT 100
NKNVQVFKNQ IKSLGFSIDW SREINTTDPE YYKWSQWIFE KLYEKGLAYE 150
DEIMVNWAPD FPGGGIVVAN EEVIDGKTER GGYPVYRKPM KQWVLRITAY 200
ADRLLEDLED LDWPEAIKEQ QRHWIGKSIG ASVFFNIADS DKQIEVYTTR 250
PDTLFGAQYM VLSPEHELVD EITTLEQKEA IANYKKEVET KSDLERTDLN 300
KDKTGAFTGA YATNPINGEK LPIWIADYVL SSYGTGAIMA VPAHDDRDWE 350
FAKKFNLPIK AVIEGGNVEE AAYTDDGTHI NSGFLDGLNK QEAIDKAISW 400
LEEHNAGHQQ INYRLRDWIF SRQRYWGEPI PVIHWEDGTQ TLVPESELPL 450
RLPEMTQEQL KPSGTGESPL ANATDWLNVT RKDGVKGRRE TNTMPQWAGS 500
SWYFLRYVDP HNSEALADPE KLKYWMNVDL YVGGAEHAVL HLLYARFWHK 550
FLYDLGVVPT KEPFQKLVNQ GMILGENHEK MSKSKGNVVN PDEIVNNYGA 600
DTLRVYEMFM GPLTQSKPWS EDGVSGSRRW LDRVWRLLVD EEDKLRDHVT 650
TVNKGDLDKI YHQTVKKVSE DLENMRFNTA ISQLMVFVNE AYKSEALPVQ 700
YMDGFVQMLA PIAPHLAEEL WSKLGHEEDI SYVSWPTYDE SQLVEDSVEI 750
IFQVNGKVRG KATVARNIDK DAMLDYAKAD ENVQNFISGK EIRKIIAIPG 800
KFVNIVVG 808
Length:808
Mass (Da):92,689
Last modified:November 14, 2006 - v1
Checksum:i437DB9D2DDD86F42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000414 Genomic DNA. Translation: ABJ61748.1.
RefSeqiWP_011679445.1. NC_008531.1.
YP_818121.1. NC_008531.1.

Genome annotation databases

EnsemblBacteriaiABJ61748; ABJ61748; LEUM_0635.
GeneIDi4422468.
KEGGilme:LEUM_0635.
PATRICi22409255. VBILeuMes50664_0631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000414 Genomic DNA. Translation: ABJ61748.1 .
RefSeqi WP_011679445.1. NC_008531.1.
YP_818121.1. NC_008531.1.

3D structure databases

ProteinModelPortali Q03YH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203120.LEUM_0635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ61748 ; ABJ61748 ; LEUM_0635 .
GeneIDi 4422468.
KEGGi lme:LEUM_0635.
PATRICi 22409255. VBILeuMes50664_0631.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LMES203120:GJ8T-635-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8293 / NCDO 523.

Entry informationi

Entry nameiSYL_LEUMM
AccessioniPrimary (citable) accession number: Q03YH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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