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Q03YB1

- FTHS_LEUMM

UniProt

Q03YB1 - FTHS_LEUMM

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, LEUM_0701
Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMES203120:GJ8T-701-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:LEUM_0701
OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Taxonomic identifieri203120 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000000362: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000300527Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203120.LEUM_0701.

Structurei

3D structure databases

ProteinModelPortaliQ03YB1.
SMRiQ03YB1. Positions 4-552.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03YB1-1 [UniParc]FASTAAdd to Basket

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MQTDIEIAQS VEIKPITKIA TTAGLQANEI EPYGYDKAKI NLDPSIVRKQ    50
ELGKLILVTS INPTPAGEGK STVTVGLADA LNLADKKTMI ALREPSLGPV 100
MGLKGGATGG GFAQVVPMAD INLHFTGDFH ALTSAHDTLA ALLDNSIHQG 150
NPLNIDPRRI LWKRVVDIND RELRHVTVGL GGPTSGVPRE DGFDITVASE 200
LMAILTLSTD LMDMKERIKR IVVGYTYSKE PVTVADLGVA GALTVLLKDA 250
IKPNLVQTLA HTPAIIHGGP FANIAQGTNS ILATKTALKL ADYVVTEAGF 300
GADLGGEKFL DVKVPLLGKT PDTIVIVATV RALKHHGGVA LSNLNNEDVT 350
ALRNGLENLG QHLTAMNRYG VPVLVAINRF TSDTEAELQV IKDYVQQFGA 400
TAYTTEVWAK GGAGAQELAA AVIKKSAQEA DFTPLYQADD SAIDKLNTIV 450
QTIYGGTGVE LSTKAQKQLQ DFKKYGWDKL PIIMAKTQYS FTDDAKKLGA 500
PKDFKIYIRE FVPKLGAGFL VALTGSIMTM PGLPKHPAAL DIDIDENGTI 550
TGLF 554
Length:554
Mass (Da):59,178
Last modified:November 14, 2006 - v1
Checksum:i40AF51A0C05941EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000414 Genomic DNA. Translation: ABJ61811.1.
RefSeqiYP_818184.1. NC_008531.1.

Genome annotation databases

EnsemblBacteriaiABJ61811; ABJ61811; LEUM_0701.
GeneIDi4422534.
KEGGilme:LEUM_0701.
PATRICi22409391. VBILeuMes50664_0698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000414 Genomic DNA. Translation: ABJ61811.1 .
RefSeqi YP_818184.1. NC_008531.1.

3D structure databases

ProteinModelPortali Q03YB1.
SMRi Q03YB1. Positions 4-552.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203120.LEUM_0701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ61811 ; ABJ61811 ; LEUM_0701 .
GeneIDi 4422534.
KEGGi lme:LEUM_0701.
PATRICi 22409391. VBILeuMes50664_0698.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LMES203120:GJ8T-701-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8293 / NCDO 523.

Entry informationi

Entry nameiFTHS_LEUMM
AccessioniPrimary (citable) accession number: Q03YB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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