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Q03YB1

- FTHS_LEUMM

UniProt

Q03YB1 - FTHS_LEUMM

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMES203120:GJ8T-701-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LEUM_0701
    OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
    Taxonomic identifieri203120 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
    ProteomesiUP000000362: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_0000300527Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203120.LEUM_0701.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03YB1.
    SMRiQ03YB1. Positions 4-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03YB1-1 [UniParc]FASTAAdd to Basket

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    MQTDIEIAQS VEIKPITKIA TTAGLQANEI EPYGYDKAKI NLDPSIVRKQ    50
    ELGKLILVTS INPTPAGEGK STVTVGLADA LNLADKKTMI ALREPSLGPV 100
    MGLKGGATGG GFAQVVPMAD INLHFTGDFH ALTSAHDTLA ALLDNSIHQG 150
    NPLNIDPRRI LWKRVVDIND RELRHVTVGL GGPTSGVPRE DGFDITVASE 200
    LMAILTLSTD LMDMKERIKR IVVGYTYSKE PVTVADLGVA GALTVLLKDA 250
    IKPNLVQTLA HTPAIIHGGP FANIAQGTNS ILATKTALKL ADYVVTEAGF 300
    GADLGGEKFL DVKVPLLGKT PDTIVIVATV RALKHHGGVA LSNLNNEDVT 350
    ALRNGLENLG QHLTAMNRYG VPVLVAINRF TSDTEAELQV IKDYVQQFGA 400
    TAYTTEVWAK GGAGAQELAA AVIKKSAQEA DFTPLYQADD SAIDKLNTIV 450
    QTIYGGTGVE LSTKAQKQLQ DFKKYGWDKL PIIMAKTQYS FTDDAKKLGA 500
    PKDFKIYIRE FVPKLGAGFL VALTGSIMTM PGLPKHPAAL DIDIDENGTI 550
    TGLF 554
    Length:554
    Mass (Da):59,178
    Last modified:November 14, 2006 - v1
    Checksum:i40AF51A0C05941EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000414 Genomic DNA. Translation: ABJ61811.1.
    RefSeqiYP_818184.1. NC_008531.1.

    Genome annotation databases

    EnsemblBacteriaiABJ61811; ABJ61811; LEUM_0701.
    GeneIDi4422534.
    KEGGilme:LEUM_0701.
    PATRICi22409391. VBILeuMes50664_0698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000414 Genomic DNA. Translation: ABJ61811.1 .
    RefSeqi YP_818184.1. NC_008531.1.

    3D structure databases

    ProteinModelPortali Q03YB1.
    SMRi Q03YB1. Positions 4-552.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203120.LEUM_0701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ61811 ; ABJ61811 ; LEUM_0701 .
    GeneIDi 4422534.
    KEGGi lme:LEUM_0701.
    PATRICi 22409391. VBILeuMes50664_0698.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LMES203120:GJ8T-701-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8293 / NCDO 523.

    Entry informationi

    Entry nameiFTHS_LEUMM
    AccessioniPrimary (citable) accession number: Q03YB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3