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Q03YB1 (FTHS_LEUMM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LEUM_0701
OrganismLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]
Taxonomic identifier203120 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostoc

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300527

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03YB1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 40AF51A0C05941EC

FASTA55459,178
        10         20         30         40         50         60 
MQTDIEIAQS VEIKPITKIA TTAGLQANEI EPYGYDKAKI NLDPSIVRKQ ELGKLILVTS 

        70         80         90        100        110        120 
INPTPAGEGK STVTVGLADA LNLADKKTMI ALREPSLGPV MGLKGGATGG GFAQVVPMAD 

       130        140        150        160        170        180 
INLHFTGDFH ALTSAHDTLA ALLDNSIHQG NPLNIDPRRI LWKRVVDIND RELRHVTVGL 

       190        200        210        220        230        240 
GGPTSGVPRE DGFDITVASE LMAILTLSTD LMDMKERIKR IVVGYTYSKE PVTVADLGVA 

       250        260        270        280        290        300 
GALTVLLKDA IKPNLVQTLA HTPAIIHGGP FANIAQGTNS ILATKTALKL ADYVVTEAGF 

       310        320        330        340        350        360 
GADLGGEKFL DVKVPLLGKT PDTIVIVATV RALKHHGGVA LSNLNNEDVT ALRNGLENLG 

       370        380        390        400        410        420 
QHLTAMNRYG VPVLVAINRF TSDTEAELQV IKDYVQQFGA TAYTTEVWAK GGAGAQELAA 

       430        440        450        460        470        480 
AVIKKSAQEA DFTPLYQADD SAIDKLNTIV QTIYGGTGVE LSTKAQKQLQ DFKKYGWDKL 

       490        500        510        520        530        540 
PIIMAKTQYS FTDDAKKLGA PKDFKIYIRE FVPKLGAGFL VALTGSIMTM PGLPKHPAAL 

       550 
DIDIDENGTI TGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000414 Genomic DNA. Translation: ABJ61811.1.
RefSeqYP_818184.1. NC_008531.1.

3D structure databases

ProteinModelPortalQ03YB1.
SMRQ03YB1. Positions 4-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203120.LEUM_0701.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ61811; ABJ61811; LEUM_0701.
GeneID4422534.
KEGGlme:LEUM_0701.
PATRIC22409391. VBILeuMes50664_0698.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK2318857.

Enzyme and pathway databases

BioCycLMES203120:GJ8T-701-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LEUMM
AccessionPrimary (citable) accession number: Q03YB1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways