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Q03Y85

- PUR9_LEUMM

UniProt

Q03Y85 - PUR9_LEUMM

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, LEUM_0727
Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLMES203120:GJ8T-727-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:LEUM_0727
OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Taxonomic identifieri203120 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000000362: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018906Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203120.LEUM_0727.

Structurei

3D structure databases

ProteinModelPortaliQ03Y85.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03Y85-1 [UniParc]FASTAAdd to Basket

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MTRALLSVSD KSGLIPFAKN LVELGYELVS TGGTHKVLID AGLDVISIDE    50
VTDFPEMLDG RVKTLHPRVH AGLLARRDLP EHMAKLAEFD ITPIDMVVVN 100
LYPFKSTIQK EGVTEAEAIE NIDIGGPSML RSAAKNFASV LPIVDPKDYD 150
VVVNKLKAGE VDREYRKSLA AKVFQHTASY DALIANYLTE TSFPENLTLA 200
YEKFDDMRYG ENPHQPAAAY KTALPEAYSV LNADILHGKQ LSYNNIRDAD 250
AALRIIAEYE ETTVVTVKHM NPAGIGQGQT LEAAWDQAFA ADDISIFGGI 300
VALNREVDAA TAEKMHDIFL EIIIAPSFTP EAYEILAAKK NLRLLTLPFT 350
TSIPQKLEVT SVLGGVVVQE RDLVGESENN FTVVSKAQPT KEQLQAMVFA 400
QKVVKHVKSN AIVVARNGQT LGIGAGQPNR IDSVVYSIQK AEKKPGFDEA 450
VLASDAFFPM DDSVQYAAEH GIKAIVEPGG SIKDKDSIAK ADELGVVLIF 500
SGTRHFKH 508
Length:508
Mass (Da):55,403
Last modified:November 14, 2006 - v1
Checksum:i5D06C6C17770963E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000414 Genomic DNA. Translation: ABJ61837.1.
RefSeqiWP_011679517.1. NC_008531.1.
YP_818210.1. NC_008531.1.

Genome annotation databases

EnsemblBacteriaiABJ61837; ABJ61837; LEUM_0727.
GeneIDi4422560.
KEGGilme:LEUM_0727.
PATRICi22409441. VBILeuMes50664_0723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000414 Genomic DNA. Translation: ABJ61837.1 .
RefSeqi WP_011679517.1. NC_008531.1.
YP_818210.1. NC_008531.1.

3D structure databases

ProteinModelPortali Q03Y85.
ModBasei Search...

Protein-protein interaction databases

STRINGi 203120.LEUM_0727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ61837 ; ABJ61837 ; LEUM_0727 .
GeneIDi 4422560.
KEGGi lme:LEUM_0727.
PATRICi 22409441. VBILeuMes50664_0723.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LMES203120:GJ8T-727-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8293 / NCDO 523.

Entry informationi

Entry nameiPUR9_LEUMM
AccessioniPrimary (citable) accession number: Q03Y85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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