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Q03Y85 (PUR9_LEUMM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:LEUM_0727
OrganismLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]
Taxonomic identifier203120 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostoc

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018906

Sequences

Sequence LengthMass (Da)Tools
Q03Y85 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 5D06C6C17770963E

FASTA50855,403
        10         20         30         40         50         60 
MTRALLSVSD KSGLIPFAKN LVELGYELVS TGGTHKVLID AGLDVISIDE VTDFPEMLDG 

        70         80         90        100        110        120 
RVKTLHPRVH AGLLARRDLP EHMAKLAEFD ITPIDMVVVN LYPFKSTIQK EGVTEAEAIE 

       130        140        150        160        170        180 
NIDIGGPSML RSAAKNFASV LPIVDPKDYD VVVNKLKAGE VDREYRKSLA AKVFQHTASY 

       190        200        210        220        230        240 
DALIANYLTE TSFPENLTLA YEKFDDMRYG ENPHQPAAAY KTALPEAYSV LNADILHGKQ 

       250        260        270        280        290        300 
LSYNNIRDAD AALRIIAEYE ETTVVTVKHM NPAGIGQGQT LEAAWDQAFA ADDISIFGGI 

       310        320        330        340        350        360 
VALNREVDAA TAEKMHDIFL EIIIAPSFTP EAYEILAAKK NLRLLTLPFT TSIPQKLEVT 

       370        380        390        400        410        420 
SVLGGVVVQE RDLVGESENN FTVVSKAQPT KEQLQAMVFA QKVVKHVKSN AIVVARNGQT 

       430        440        450        460        470        480 
LGIGAGQPNR IDSVVYSIQK AEKKPGFDEA VLASDAFFPM DDSVQYAAEH GIKAIVEPGG 

       490        500 
SIKDKDSIAK ADELGVVLIF SGTRHFKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000414 Genomic DNA. Translation: ABJ61837.1.
RefSeqYP_818210.1. NC_008531.1.

3D structure databases

ProteinModelPortalQ03Y85.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203120.LEUM_0727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ61837; ABJ61837; LEUM_0727.
GeneID4422560.
KEGGlme:LEUM_0727.
PATRIC22409441. VBILeuMes50664_0723.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycLMES203120:GJ8T-727-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_LEUMM
AccessionPrimary (citable) accession number: Q03Y85
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways