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Q03XP2 (Q03XP2_LEUMM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:LEUM_0924
OrganismLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]
Taxonomic identifier203120 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding74 – 763NADP By similarity PIRSR PIRSR000109-3
Region128 – 1303Substrate binding By similarity PIRSR PIRSR000109-2
Region187 – 1882Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1841Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1911Proton donor By similarity PIRSR PIRSR000109-1
Binding site1021NADP By similarity PIRSR PIRSR000109-3
Binding site1021Substrate By similarity PIRSR PIRSR000109-2
Binding site1921Substrate By similarity PIRSR PIRSR000109-2
Binding site2631Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2901Substrate By similarity PIRSR PIRSR000109-2
Binding site4481Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q03XP2 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 2AB9BA901E72D1D7

FASTA47552,804
        10         20         30         40         50         60 
MEQADFGVVG LAVMGRNLAL NIESRGYRVA VYNRSRERTD DLVQKHEDKA FIPSYTTEEF 

        70         80         90        100        110        120 
VETIKKPRRI LLMVKAGKGT DAVIDELLPH LEKGDMLIDG GNTYFEDTIR RSDKLAQEGI 

       130        140        150        160        170        180 
NFIGMGVSGG ELGALQGPSL MPGGQREAYD LVAPILTQIA AKAPEDGKPT VTYIGPNGAG 

       190        200        210        220        230        240 
HYVKMVHNGI EYGDMQLIAE SYDILKRVLH LNQEQLSQTF SGWNEGELNS YLVEITADIL 

       250        260        270        280        290        300 
TRKDDLGTDK PIVDVILDRA GNKGTGKWSS QSALEVGAPQ SLITESVYAR YISAMKDDRV 

       310        320        330        340        350        360 
AASKTLQGPD YSFSGDEQST VEDIRKALYF GKIMSYAQGF DQLRMASEHY DWHLPFGELA 

       370        380        390        400        410        420 
QLWRAGAIIR AQFLQRITDA FTTQADLHNL LLDPYFQHIA EEYQNAARRV VALAVTAGVP 

       430        440        450        460        470 
TPSLSAAVAY YDSYRSAVLP ANLTQAQRDY FGAHTYERTD KPAGEMYHYP WYDEA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000414 Genomic DNA. Translation: ABJ62030.1.
RefSeqYP_818403.1. NC_008531.1.

3D structure databases

ProteinModelPortalQ03XP2.
SMRQ03XP2. Positions 3-472.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ03XP2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4422703.
GenomeReviewsGene locus LEUM_0924 in contig CP000414_GR.
KEGGlme:LEUM_0924.
NMPDRfig|203120.1.peg.87.
PATRIC22409839. VBILeuMes50664_0921.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBQ03XP2.
ProtClustDBCLSK2318919.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ03XP2_LEUMM
AccessionPrimary (citable) accession number: Q03XP2
Entry history
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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