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Q03XM8 (THIM2_LEUMM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase 2

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2
Short name=TH kinase 2
Short name=Thz kinase 2
Gene names
Name:thiM2
Ordered Locus Names:LEUM_0938
OrganismLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]
Taxonomic identifier203120 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Hydroxyethylthiazole kinase 2 HAMAP-Rule MF_00228
PRO_0000383882

Sites

Binding site451Substrate; via amide nitrogen By similarity
Binding site1201ATP By similarity
Binding site1731ATP By similarity
Binding site2001Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03XM8 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: B63CEDA0C4745284

FASTA27329,923
        10         20         30         40         50         60 
MKNELIKIKS ILPLQKAPLV HCITNDITLE TVANTILYLG GKPIMSSDTR EFSSLFQSTD 

        70         80         90        100        110        120 
ALLLNMGRLN ESHEQSLSQA SSLADMTKKP TVVDLVGYGI TNERTKLGMA MARNHPTVIK 

       130        140        150        160        170        180 
GNTSEIRRFV GLPSLAKGID GASSDQHDQA LKDLILSLKQ ITTEYADTVF VATGKKDVIV 

       190        200        210        220        230        240 
QNDKHLILSN GVDELDKFVG TGDMVGAIIT TLLAVGEDPW VASQFAISYL NVAAEKALSL 

       250        260        270 
TNGMENFRRE VLNQIDLLGR NQQWATKIKY SNF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000414 Genomic DNA. Translation: ABJ62044.1.
RefSeqYP_818417.1. NC_008531.1.

3D structure databases

ProteinModelPortalQ03XM8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203120.LEUM_0938.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ62044; ABJ62044; LEUM_0938.
GeneID4422717.
KEGGlme:LEUM_0938.
PATRIC22409867. VBILeuMes50664_0935.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAAKPIMAE.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycLMES203120:GJ8T-938-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM2_LEUMM
AccessionPrimary (citable) accession number: Q03XM8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways