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Q03WU9

- TRMB_LEUMM

UniProt

Q03WU9 - TRMB_LEUMM

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461S-adenosyl-L-methionineUniRule annotation
Binding sitei71 – 711S-adenosyl-L-methionineUniRule annotation
Binding sitei100 – 1001S-adenosyl-L-methionineUniRule annotation
Active sitei122 – 1221By similarity
Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLMES203120:GJ8T-1225-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:LEUM_1225
OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Taxonomic identifieri203120 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000000362: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219tRNA (guanine-N(7)-)-methyltransferasePRO_0000288171Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203120.LEUM_1225.

Structurei

3D structure databases

ProteinModelPortaliQ03WU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03WU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLRSKPWAS DWLAEHSDIV IDQDRATAQI GQWQSLFDQE QPIHLEIGSG
60 70 80 90 100
KGQFILGMAL AHPEINYIGM EIQETAIAIA ARKSFDQVGT LPNLRYIYGN
110 120 130 140 150
GNGVETYFEK GEVSKVYLNF SDPWPKKRHE SRRLTYKSFL KSYEAVLPEH
160 170 180 190 200
GEVEFKTDNR HLFEYSMVSF MDYGMRWTPE DYTLDLHADE DKVQGNVETE
210
YEQKFMAKGQ PIYKIKAHF
Length:219
Mass (Da):25,462
Last modified:November 14, 2006 - v1
Checksum:iCF4E71AD5280019D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000414 Genomic DNA. Translation: ABJ62323.1.
RefSeqiYP_818696.1. NC_008531.1.

Genome annotation databases

EnsemblBacteriaiABJ62323; ABJ62323; LEUM_1225.
GeneIDi4422990.
KEGGilme:LEUM_1225.
PATRICi22410439. VBILeuMes50664_1222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000414 Genomic DNA. Translation: ABJ62323.1 .
RefSeqi YP_818696.1. NC_008531.1.

3D structure databases

ProteinModelPortali Q03WU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203120.LEUM_1225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ62323 ; ABJ62323 ; LEUM_1225 .
GeneIDi 4422990.
KEGGi lme:LEUM_1225.
PATRICi 22410439. VBILeuMes50664_1222.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci LMES203120:GJ8T-1225-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8293 / NCDO 523.

Entry informationi

Entry nameiTRMB_LEUMM
AccessioniPrimary (citable) accession number: Q03WU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3