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Q03W70

- ASSY_LEUMM

UniProt

Q03W70 - ASSY_LEUMM

Protein

Argininosuccinate synthase

Gene

argG

Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861CitrullineUniRule annotation
    Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181AspartateUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei122 – 1221CitrullineUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei174 – 1741CitrullineUniRule annotation
    Binding sitei259 – 2591CitrullineUniRule annotation
    Binding sitei271 – 2711CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMES203120:GJ8T-1459-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:LEUM_1459
    OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
    Taxonomic identifieri203120 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
    ProteomesiUP000000362: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Argininosuccinate synthasePRO_0000321312Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi203120.LEUM_1459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03W70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03W70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDTLVLAYS GGLDTSVAIP WLKDKGYDVI AVVLDVGQHG KNLNEIQAKA    50
    LKVGAKQSIV IDAKAEFADK YVAPVIKANM MYEGEYPMVS ALSRPLIIKK 100
    LVDIAHENDA VAIAHGSTGH GNDQVRFEAA IHALDPDMKI EAPIRDFQWS 150
    REEEIQYAQE HDVPVPIDLD SPYSIDENLW GRANEAGILE NPWNQAPEDA 200
    FALTTAIEDA PDTPEFIDVT FEAGVPVALN GEVLSLEKLI VAVNEIAGKH 250
    GIGRIDHIEN RLVGIKSREI YEAPAAAVLM TAHKDLEDLT LERDVAHFKP 300
    IVEQQLANLV YEAKWVSPLF DSLMAFIDST QQNVNGVVKM KLFKGNATAV 350
    ARQSEHNSLY DEDLATYTSS SSFDQASAVG FIKLWTLSNT VYEQVNHVHS 400
    QAKKNTVK 408
    Length:408
    Mass (Da):44,912
    Last modified:November 14, 2006 - v1
    Checksum:i50269E18745D5E45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000414 Genomic DNA. Translation: ABJ62552.1.
    RefSeqiYP_818925.1. NC_008531.1.

    Genome annotation databases

    EnsemblBacteriaiABJ62552; ABJ62552; LEUM_1459.
    GeneIDi4423189.
    KEGGilme:LEUM_1459.
    PATRICi22410901. VBILeuMes50664_1450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000414 Genomic DNA. Translation: ABJ62552.1 .
    RefSeqi YP_818925.1. NC_008531.1.

    3D structure databases

    ProteinModelPortali Q03W70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203120.LEUM_1459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ62552 ; ABJ62552 ; LEUM_1459 .
    GeneIDi 4423189.
    KEGGi lme:LEUM_1459.
    PATRICi 22410901. VBILeuMes50664_1450.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci LMES203120:GJ8T-1459-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8293 / NCDO 523.

    Entry informationi

    Entry nameiASSY_LEUMM
    AccessioniPrimary (citable) accession number: Q03W70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3