Q03VW4 (GLMM_LEUMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	LEUM_1566

Organism

Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) [Complete proteome] [HAMAP]

Taxonomic identifier

203120 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_0000305649
Sites
	Active site	108	1	Phosphoserine intermediate By similarity
	Metal binding	108	1	Magnesium; via phosphate group By similarity
	Metal binding	248	1	Magnesium By similarity
	Metal binding	250	1	Magnesium By similarity
	Metal binding	252	1	Magnesium By similarity
Amino acid modifications
	Modified residue	108	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q03VW4 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: E70583E177067BBE	FASTA	455	49,054
	10 20 30 40 50 60 MSEFNLKYFG TDGVRGVANK TLTPELAFRL GRTGGAILTR HANDENKKPV VIVGRDTRIS 70 80 90 100 110 120 GEMLQQAIIA GFLSVGIDVL RLGVITTPAV AFLVQNLEAD AGVQITASHN PAADNGIKFF 130 140 150 160 170 180 GNDGFKLSDQ LEYEIEQLLD ESEDTLPRPS ADGLGVVNNY PEGVQKYLEF LQKTIPTDLN 190 200 210 220 230 240 GMRIALDGAN GATSGLLARL FADLGTDFVT LGTEPNGLNI NDGVGSTNPA ALAELVKEND 250 260 270 280 290 300 VQAGLAFDGD GDRLIAVDEN GEIVDGDKIM FITGKFLNEQ GRLKHNAVVS TVMSNIGFYK 310 320 330 340 350 360 ALAENDMTSI KTAVGDRYVM EEMIKSDHNL GGEQSGHIIF RDWATTGDGL LTALQLLYVM 370 380 390 400 410 420 KETGKKLSEL AAPVHIYPQK LVNITVADKE EIQHDPDVIA KIAEVEAQMA GDGRVLVRPS 430 440 450 GTEPLLRVMV EAPTQELVEK YTESIANVVR EKSGL

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8293 / NCDO 523.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000414 Genomic DNA. Translation: ABJ62658.1.
RefSeq	YP_819031.1. NC_008531.1.
3D structure databases
ProteinModelPortal	Q03VW4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03VW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4423296.
GenomeReviews	Gene locus LEUM_1566 in contig CP000414_GR.
KEGG	lme:LEUM_1566.
NMPDR	fig|203120.1.peg.146.
PATRIC	22411113. VBILeuMes50664_1555.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	GVGSTHL.
PhylomeDB	Q03VW4.
ProtClustDB	PRK14316.
Enzyme and pathway databases
BioCyc	LMES203120:LEUM_1566-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_LEUMM

Accession

Primary (citable) accession number: Q03VW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program