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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei264ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:LVIS_0080
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003676951 – 503Glutamate--tRNA ligase 1Add BLAST503

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi387344.LVIS_0080

Structurei

3D structure databases

ProteinModelPortaliQ03U68
SMRiQ03U68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi17 – 27"HIGH" regionUniRule annotationAdd BLAST11
Motifi261 – 265"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK09698
OMAiHYINTLP

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q03U68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENSTVKKN VRVRYAPSPT GFLHIGNAQS ALFNYLFARH YHGTMVLRIE
60 70 80 90 100
DTDVKRNVPH GEDSQIDNLH WLGIDWDEGP DKPNPKYAPY HQTERQDLYH
110 120 130 140 150
RYITQLLDQG LAYKDYATED ELTTMRDQQR AAGEAPHYDG RWYGRSVADQ
160 170 180 190 200
QAAEARGLKP SIRLHLPANH EYAWDDIIKG HVAFNSDNMG GDFIIEKSNG
210 220 230 240 250
MPTYNFAVVI DDYLMDITDV LRGDDHIANT PKQIAVYEAL GLKHPNFGHI
260 270 280 290 300
TLIYNPKTRK KLSKRDKETL QFISQYKNQG YLSEAIFNFI AFLGWSPEGE
310 320 330 340 350
DELFSREELI ERYDPARMSK SPAYFDQSKL DWINAAYIKR LDLDDMTDRV
360 370 380 390 400
LELVDEGQTD VARQVKALQL PDLRTLTSQV CKIYQTEIHQ LSEIMDKVLF
410 420 430 440 450
YVTILQEPLD YDQLRQFDRT ATLAVLTAFR KHVQALPVDV ATPDFKKMIQ
460 470 480 490 500
TVSQETGVTG RNLYFPLNVA FTGDHSAPQI DEVLRLFANS TIIELLTKAI

AHV
Length:503
Mass (Da):57,736
Last modified:November 14, 2006 - v1
Checksum:iF4FED28A21F61247
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA Translation: ABJ63254.1

Genome annotation databases

EnsemblBacteriaiABJ63254; ABJ63254; LVIS_0080
KEGGilbr:LVIS_0080

Similar proteinsi

Entry informationi

Entry nameiSYE1_LACBA
AccessioniPrimary (citable) accession number: Q03U68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health