Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q03U68

- SYE1_LACBA

UniProt

Q03U68 - SYE1_LACBA

Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei264 – 2641ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLBRE387344:GJ8S-80-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetase 1UniRule annotation
    Short name:
    GluRS 1UniRule annotation
    Gene namesi
    Name:gltX1UniRule annotation
    Ordered Locus Names:LVIS_0080
    OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
    Taxonomic identifieri387344 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001652: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Glutamate--tRNA ligase 1PRO_0000367695Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi387344.LVIS_0080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03U68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi17 – 2711"HIGH" regionAdd
    BLAST
    Motifi261 – 2655"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK09698.
    OMAiDIDMQIS.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03U68-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENSTVKKN VRVRYAPSPT GFLHIGNAQS ALFNYLFARH YHGTMVLRIE    50
    DTDVKRNVPH GEDSQIDNLH WLGIDWDEGP DKPNPKYAPY HQTERQDLYH 100
    RYITQLLDQG LAYKDYATED ELTTMRDQQR AAGEAPHYDG RWYGRSVADQ 150
    QAAEARGLKP SIRLHLPANH EYAWDDIIKG HVAFNSDNMG GDFIIEKSNG 200
    MPTYNFAVVI DDYLMDITDV LRGDDHIANT PKQIAVYEAL GLKHPNFGHI 250
    TLIYNPKTRK KLSKRDKETL QFISQYKNQG YLSEAIFNFI AFLGWSPEGE 300
    DELFSREELI ERYDPARMSK SPAYFDQSKL DWINAAYIKR LDLDDMTDRV 350
    LELVDEGQTD VARQVKALQL PDLRTLTSQV CKIYQTEIHQ LSEIMDKVLF 400
    YVTILQEPLD YDQLRQFDRT ATLAVLTAFR KHVQALPVDV ATPDFKKMIQ 450
    TVSQETGVTG RNLYFPLNVA FTGDHSAPQI DEVLRLFANS TIIELLTKAI 500
    AHV 503
    Length:503
    Mass (Da):57,736
    Last modified:November 14, 2006 - v1
    Checksum:iF4FED28A21F61247
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ63254.1.
    RefSeqiYP_794285.1. NC_008497.1.

    Genome annotation databases

    EnsemblBacteriaiABJ63254; ABJ63254; LVIS_0080.
    GeneIDi4412658.
    KEGGilbr:LVIS_0080.
    PATRICi22199128. VBILacBre134470_0079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ63254.1 .
    RefSeqi YP_794285.1. NC_008497.1.

    3D structure databases

    ProteinModelPortali Q03U68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387344.LVIS_0080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ63254 ; ABJ63254 ; LVIS_0080 .
    GeneIDi 4412658.
    KEGGi lbr:LVIS_0080.
    PATRICi 22199128. VBILacBre134470_0079.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K09698.
    OMAi DIDMQIS.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci LBRE387344:GJ8S-80-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 367 / JCM 1170.

    Entry informationi

    Entry nameiSYE1_LACBA
    AccessioniPrimary (citable) accession number: Q03U68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3