Q03U06 (UXUA_LACBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	LVIS_0146

Organism

Lactobacillus brevis (strain ATCC 367 / JCM 1170) [Complete proteome] [HAMAP]

Taxonomic identifier

387344 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Mannonate dehydratase HAMAP MF_00106		PRO_1000034332

Sequences

	Sequence		Length	Mass (Da)
	Q03U06 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: EE966DA32DA89EC8	FASTA	356	40,274
	10 20 30 40 50 60 MEMGFRWYGS QNDQIHLADI RQIPGVRQVV GALFDIPVGE VWPEDQIIRL KHQIEAAGLK 70 80 90 100 110 120 FTVVESVNIH DDIKIGLPSR DRYIENYQQT IRNLAAAGVR TICYNFMPIF DWVRTNLHFS 130 140 150 160 170 180 LADGSQALAF EHRQVQRQPQ DIIHEIENNA NGFVLPGWEP ERLAQVQQLF DAYAGVDETQ 190 200 210 220 230 240 LAANLNYFLD AIIPVCEECH VQMALHPDDP PRELFGLPRI YKNLADMNRI VAMNPSTANG 250 260 270 280 290 300 FTICTGSLGE NPQNDVPAII REFVPQGRVP FVHARNIKFM SDQGDFHESA HLSSMGSLDM 310 320 330 340 350 FAIMQALHET GFSGVIRPDH GRDIWHESGR PGYGLYDRAL GITYLNGLWE ALEKQA

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 367 / JCM 1170.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000416 Genomic DNA. Translation: ABJ63316.1.
RefSeq	YP_794347.1. NC_008497.1.
3D structure databases
ProteinModelPortal	Q03U06.
SMR	Q03U06. Positions 1-355.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03U06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4413533.
GenomeReviews	Gene locus LVIS_0146 in contig CP000416_GR.
KEGG	lbr:LVIS_0146.
NMPDR	fig|387344.8.peg.138.
PATRIC	22199264. VBILacBre134470_0144.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	DIKLGKP.
PhylomeDB	Q03U06.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	LBRE387344:LVIS_0146-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_LACBA

Accession

Primary (citable) accession number: Q03U06

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program