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Reviewed, UniProtKB/Swiss-Prot Q03TT0 (GUAC_LACBA)

Last modified November 25, 2008. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    GMP reductase
    EC=1.7.1.7
Alternative name(s):
    Guanosine 5'-monophosphate oxidoreductase
      Short name=Guanosine monophosphate reductase
Gene names
Name: guaC
Ordered Locus Names: LVIS_0226
OrganismLactobacillus brevis (strain ATCC 367 / JCM 1170) [Complete proteome] [HAMAP]
Taxonomic identifier387344 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity.

Catalytic activity

Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords

   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: InterPro

purine nucleotide metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328GMP reductase
PRO_0000292050

Regions

Nucleotide binding206 – 22924NADP Potential

Sites

Active site1771Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03TT0-1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: DD7A0C66BF41F14B

FASTA32836,006
        10         20         30         40         50         60 
MHPAEVFDYE DIQLVPNKCI IDSRSEADTS IEFGPRRFKI PVVPANMETV INEPLAVWLA 

        70         80         90        100        110        120 
EHDYFYVMHR FQPEDRRGFI ERMQAKSLFA SISVGVKPEE VTFIDELATA GLTPEYITID 

       130        140        150        160        170        180 
IAHGHSDAVI RMIHHIKQQL PNSFVIAGNV GTPEAVRELE NAGADATKVG IGPGKACITK 

       190        200        210        220        230        240 
LKTGFGTGGW QLAAVRLCAK AARKPIVADG GIRYNGDIAK SIRFGASMVM IGSMLAGHEQ 

       250        260        270        280        290        300 
SPGSLLTIDG RTFKQYWGSA SEKQKGAYRN VEGKQMLVPY RGDIDQTLTA MEEDLQSAIS 

       310        320 
YAGGRNLLDI RTVDYVIVKS SILNGDNY 

« Hide

Cross-references

Sequence databases

CP000416 Genomic DNA. Translation: ABJ63392.1.
RefSeqYP_794423.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4413048.
GenomeReviewsGene locus LVIS_0226 in contig CP000416_GR.
KEGGlbr:LVIS_0226.
NMPDRfig|387344.8.peg.218.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ03TT0.

Family and domain databases

HAMAPMF_01511.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DHase_GMPRtase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_LACBA
AccessionPrimary (citable) accession number: Q03TT0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 14, 2006
Last modified: November 25, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents