Q03SX5 (Q03SX5_LACBA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Homoserine kinase EMBL ABJ63697.1
EC=2.7.1.39 EMBL ABJ63697.1

Gene names

Ordered Locus Names:

LVIS_0548

Organism

Lactobacillus brevis (strain ATCC 367 / JCM 1170) [Complete proteome] [HAMAP]

Taxonomic identifier

387344 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. SAAS SAAS000870
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. SAAS SAAS000870
Subcellular location	Cytoplasm By similarity SAAS SAAS000870.
Sequence similarities	Belongs to the GHMP kinase family. RuleBase RU004209

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis SAAS SAAS000870
Cellular component	Cytoplasm SAAS SAAS000870
Ligand	ATP-binding RuleBase RU003563 SAAS SAAS000870 Nucleotide-binding
Molecular function	Kinase RuleBase RU003563 SAAS SAAS000870 EMBL ABJ63697.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q03SX5 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 12854586763C5AB7	FASTA	293	31,205
	10 20 30 40 50 60 MGKTIIRVPA TAANLGPGID SIGAALHLYL TVIIEEKTEK WRVNHALGTE IPRDENNLMV 70 80 90 100 110 120 KTALQVNPKL TPHQLTVMSD IPVSRGLGSS TSAIIAGIKI ANELGEMDLT IPEQLNWAVK 130 140 150 160 170 180 LGGELDNVAP ALLGQAAVAT VNEDEATAIK LPLPELRVLV FIPGQKLLAR KSREALPKDL 190 200 210 220 230 240 PFATAVHASG VANVLVAALL TKDWELAAKM IERDEFHEQA RSQLVPELKQ IRDAAHELGI 250 260 270 280 290 TGTYLSGAGP TVVTFGTSAQ VTLLRTKLAK LDLAGSLRIL DLDPDGATVL TDA

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000416 Genomic DNA. Translation: ABJ63697.1.
RefSeq	YP_794728.1. NC_008497.1.
3D structure databases
ProteinModelPortal	Q03SX5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03SX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4414426.
GenomeReviews	Gene locus LVIS_0548 in contig CP000416_GR.
KEGG	lbr:LVIS_0548.
NMPDR	fig|387344.8.peg.519.
PATRIC	22200058. VBILacBre134470_0528.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0083.
HOGENOM	HBG646290.
OMA	NNALMST.
PhylomeDB	Q03SX5.
ProtClustDB	PRK01212.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q03SX5_LACBA

Accession

Primary (citable) accession number: Q03SX5

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)