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Protein

Carbamoyl-phosphate synthase (glutamine-hydrolyzing)

Gene

LVIS_0829

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.SAAS annotation

Cofactori

Mn2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ManganeseSAAS annotation, Metal-bindingSAAS annotation

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-829-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)SAAS annotation (EC:6.3.5.5SAAS annotation)
Gene namesi
Ordered Locus Names:LVIS_0829Imported
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)Imported
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Interactioni

Subunit structurei

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.SAAS annotation

Protein-protein interaction databases

STRINGi387344.LVIS_0829.

Structurei

3D structure databases

ProteinModelPortaliQ03S50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 327195ATP-graspInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CarB family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105CU6. Bacteria.
COG0458. LUCA.
HOGENOMiHOG000288793.
KOiK01955.
OMAiDMDPIGI.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF02786. CPSase_L_D2. 1 hit.
PF02787. CPSase_L_D3. 1 hit.
[Graphical view]
PRINTSiPR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF52440. SSF52440. 2 hits.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03S50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLNDIQKV LIIGGGPTEI GHETELDSAT VQIMTEFKKH GVRTLIIDNN
60 70 80 90 100
PFSVALEEIQ PTNMYVQAVT TENVRHIIEK DQPDAILPSL GGLLGIQIAQ
110 120 130 140 150
ELIEDGDIGR FGVTVLGMAP ATLRQINNPA ALNATLKEIQ EPIIEAQVVS
160 170 180 190 200
TTDEAMGMVE AIGFPLIVKP VSPRVDTNRT ICENVDDMLT ALNQGFQQSR
210 220 230 240 250
FDQCSLERSV VGYKEVEMVA VRDVADTKIL ICGLENIDPI GIHSGDSIVV
260 270 280 290 300
TPPQTLNDRE YQDLRDATFR IATELGIVGV LHLHFALNPA NQHFYVTKIA
310 320 330 340 350
PYFTRGVALA ARTTGYPIAL VVGALLLGQR LVDVKLPGGY VKQTAIMEPM
360 370 380 390 400
VDHVGVRIPL WPFQEVPDAD QHLDTVMKAV GSTIGLGRSV EEALLKSVRS
410 420 430 440 450
SQFSPRDVLP SVSNLTDGEM IRQLIHPLAN RILVLIEALR RGYSPAELSE
460 470 480 490 500
LTKIDNFYFV KLQHLLLIEQ AIKDHPLDVD VLQRARYFGF GDGMIARIWQ
510 520 530 540 550
TDTAKIRQLL ADARIAPTYK MIEPTAGEFP EKTSGFYSTF EYENESQSLG
560 570 580 590 600
ERTALVLGRG GNQLGPNSAA EYFTTEMLKQ LKRAGYHTIL MNTNPNAVAI
610 620 630 640 650
APEFSDKQYV DPIQLGDVLN VIHVEHPDIV IVPGNRHYLT RELSKLDINL
660 670 680 690 700
HVLPPDQETD QPAPEMATIG VSLFVHNQHK LAVGVMDMIA PGMNKALSQV
710 720 730 740 750
TAFRMPAELP RSRRTNLVEQ AKQAVSERQV TGMVQVLFAP KPDSDSHQLT
760 770 780 790 800
VVGVRPSRLT EMAFLSKVTG VNWVRMLTRQ HIGTLDDAEL SAIKVDIHSN
810 820 830 840 850
RVALMNAAFP FRQLHVLNRP GTTDQEVGAT IAFGSSEALT LTNLSDTDEL

DRIINRTI
Length:858
Mass (Da):94,617
Last modified:November 14, 2006 - v1
Checksum:i0B66309BAE62A35B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ63972.1.
RefSeqiWP_011667758.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ63972; ABJ63972; LVIS_0829.
GeneIDi4414730.
KEGGilbr:LVIS_0829.
PATRICi22200611. VBILacBre134470_0801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ63972.1.
RefSeqiWP_011667758.1. NC_008497.1.

3D structure databases

ProteinModelPortaliQ03S50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387344.LVIS_0829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ63972; ABJ63972; LVIS_0829.
GeneIDi4414730.
KEGGilbr:LVIS_0829.
PATRICi22200611. VBILacBre134470_0801.

Phylogenomic databases

eggNOGiENOG4105CU6. Bacteria.
COG0458. LUCA.
HOGENOMiHOG000288793.
KOiK01955.
OMAiDMDPIGI.

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-829-MONOMER.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF02786. CPSase_L_D2. 1 hit.
PF02787. CPSase_L_D3. 1 hit.
[Graphical view]
PRINTSiPR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF52440. SSF52440. 2 hits.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ03S50_LACBA
AccessioniPrimary (citable) accession number: Q03S50
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.