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Q03S45 (FTHS_LACBA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LVIS_0834
OrganismLactobacillus brevis (strain ATCC 367 / JCM 1170) [Complete proteome] [HAMAP]
Taxonomic identifier387344 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293037

Regions

Nucleotide binding61 – 688ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03S45 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 8594BA12FBC898F1

FASTA55158,459
        10         20         30         40         50         60 
MKDIEISQAT ALEPIEKIAA KVGLTADQIE PYGHTKAKIN LPLASPRPQG KLVLVTSINP 

        70         80         90        100        110        120 
TPAGEGKSTV VVGLGDALNR AGHQTVLALR EPSLGPVMGL KGGATGGGYA QVVPMEDINL 

       130        140        150        160        170        180 
HFTGDMHALT EAHDTLAALI DNHIQQGNAL RLDPRQIVWK RVLDINDRAL RQTVIGLGGR 

       190        200        210        220        230        240 
TSGVPRQDGF NITVASELMA VLCLSEDLSD LKRRVNRILI GYNMDKEPVT VGDLQVGGAI 

       250        260        270        280        290        300 
TLLLKDAIKP NLVQTLEHNP AIIHGGPFAN IAHGCNSVLA TQTALQLGEY TVTEAGFGAD 

       310        320        330        340        350        360 
LGGEKFMDIK TPVLGKTPDA VVIVATIRAL KYNGGVKRAD LETENVAALQ QGSANLKRHI 

       370        380        390        400        410        420 
HSMQQYGVPV VVAINRFTSD TDAEVAALEA EVAAIDVPVA TTTVWADGGA GAMDLADKVV 

       430        440        450        460        470        480 
AATQQPSHFT RLSPEHADLM TQMTAITQKI YGGAQVELSA KAKRQLKTFA QYGWDHLPVC 

       490        500        510        520        530        540 
MAKTQYSLTD DAHQLGAPQD FTIHVREFAP RLGAGFVVAL TGNVLTMPGL PKHPAALDMD 

       550 
IAPDGTISGL F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000416 Genomic DNA. Translation: ABJ63977.1.
RefSeqYP_795008.1. NC_008497.1.

3D structure databases

ProteinModelPortalQ03S45.
SMRQ03S45. Positions 3-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING387344.LVIS_0834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ63977; ABJ63977; LVIS_0834.
GeneID4414735.
KEGGlbr:LVIS_0834.
PATRIC22200621. VBILacBre134470_0806.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycLBRE387344:GJ8S-834-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LACBA
AccessionPrimary (citable) accession number: Q03S45
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways