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Q03S45

- FTHS_LACBA

UniProt

Q03S45 - FTHS_LACBA

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, LVIS_0834
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 688ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-834-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:LVIS_0834
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000293037Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_0834.

Structurei

3D structure databases

ProteinModelPortaliQ03S45.
SMRiQ03S45. Positions 3-549.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03S45-1 [UniParc]FASTAAdd to Basket

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MKDIEISQAT ALEPIEKIAA KVGLTADQIE PYGHTKAKIN LPLASPRPQG    50
KLVLVTSINP TPAGEGKSTV VVGLGDALNR AGHQTVLALR EPSLGPVMGL 100
KGGATGGGYA QVVPMEDINL HFTGDMHALT EAHDTLAALI DNHIQQGNAL 150
RLDPRQIVWK RVLDINDRAL RQTVIGLGGR TSGVPRQDGF NITVASELMA 200
VLCLSEDLSD LKRRVNRILI GYNMDKEPVT VGDLQVGGAI TLLLKDAIKP 250
NLVQTLEHNP AIIHGGPFAN IAHGCNSVLA TQTALQLGEY TVTEAGFGAD 300
LGGEKFMDIK TPVLGKTPDA VVIVATIRAL KYNGGVKRAD LETENVAALQ 350
QGSANLKRHI HSMQQYGVPV VVAINRFTSD TDAEVAALEA EVAAIDVPVA 400
TTTVWADGGA GAMDLADKVV AATQQPSHFT RLSPEHADLM TQMTAITQKI 450
YGGAQVELSA KAKRQLKTFA QYGWDHLPVC MAKTQYSLTD DAHQLGAPQD 500
FTIHVREFAP RLGAGFVVAL TGNVLTMPGL PKHPAALDMD IAPDGTISGL 550
F 551
Length:551
Mass (Da):58,459
Last modified:November 14, 2006 - v1
Checksum:i8594BA12FBC898F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ63977.1.
RefSeqiWP_011667763.1. NC_008497.1.
YP_795008.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ63977; ABJ63977; LVIS_0834.
GeneIDi4414735.
KEGGilbr:LVIS_0834.
PATRICi22200621. VBILacBre134470_0806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ63977.1 .
RefSeqi WP_011667763.1. NC_008497.1.
YP_795008.1. NC_008497.1.

3D structure databases

ProteinModelPortali Q03S45.
SMRi Q03S45. Positions 3-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ63977 ; ABJ63977 ; LVIS_0834 .
GeneIDi 4414735.
KEGGi lbr:LVIS_0834.
PATRICi 22200621. VBILacBre134470_0806.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LBRE387344:GJ8S-834-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiFTHS_LACBA
AccessioniPrimary (citable) accession number: Q03S45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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