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Q03S45

- FTHS_LACBA

UniProt

Q03S45 - FTHS_LACBA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 688ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-834-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LVIS_0834
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_0000293037Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_0834.

Structurei

3D structure databases

ProteinModelPortaliQ03S45.
SMRiQ03S45. Positions 3-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03S45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDIEISQAT ALEPIEKIAA KVGLTADQIE PYGHTKAKIN LPLASPRPQG
60 70 80 90 100
KLVLVTSINP TPAGEGKSTV VVGLGDALNR AGHQTVLALR EPSLGPVMGL
110 120 130 140 150
KGGATGGGYA QVVPMEDINL HFTGDMHALT EAHDTLAALI DNHIQQGNAL
160 170 180 190 200
RLDPRQIVWK RVLDINDRAL RQTVIGLGGR TSGVPRQDGF NITVASELMA
210 220 230 240 250
VLCLSEDLSD LKRRVNRILI GYNMDKEPVT VGDLQVGGAI TLLLKDAIKP
260 270 280 290 300
NLVQTLEHNP AIIHGGPFAN IAHGCNSVLA TQTALQLGEY TVTEAGFGAD
310 320 330 340 350
LGGEKFMDIK TPVLGKTPDA VVIVATIRAL KYNGGVKRAD LETENVAALQ
360 370 380 390 400
QGSANLKRHI HSMQQYGVPV VVAINRFTSD TDAEVAALEA EVAAIDVPVA
410 420 430 440 450
TTTVWADGGA GAMDLADKVV AATQQPSHFT RLSPEHADLM TQMTAITQKI
460 470 480 490 500
YGGAQVELSA KAKRQLKTFA QYGWDHLPVC MAKTQYSLTD DAHQLGAPQD
510 520 530 540 550
FTIHVREFAP RLGAGFVVAL TGNVLTMPGL PKHPAALDMD IAPDGTISGL

F
Length:551
Mass (Da):58,459
Last modified:November 14, 2006 - v1
Checksum:i8594BA12FBC898F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ63977.1.
RefSeqiYP_795008.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ63977; ABJ63977; LVIS_0834.
GeneIDi4414735.
KEGGilbr:LVIS_0834.
PATRICi22200621. VBILacBre134470_0806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ63977.1 .
RefSeqi YP_795008.1. NC_008497.1.

3D structure databases

ProteinModelPortali Q03S45.
SMRi Q03S45. Positions 3-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ63977 ; ABJ63977 ; LVIS_0834 .
GeneIDi 4414735.
KEGGi lbr:LVIS_0834.
PATRICi 22200621. VBILacBre134470_0806.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LBRE387344:GJ8S-834-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiFTHS_LACBA
AccessioniPrimary (citable) accession number: Q03S45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3