Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q03S45

- FTHS_LACBA

UniProt

Q03S45 - FTHS_LACBA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 688ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLBRE387344:GJ8S-834-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LVIS_0834
    OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
    Taxonomic identifieri387344 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001652: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_0000293037Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi387344.LVIS_0834.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03S45.
    SMRiQ03S45. Positions 3-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03S45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDIEISQAT ALEPIEKIAA KVGLTADQIE PYGHTKAKIN LPLASPRPQG    50
    KLVLVTSINP TPAGEGKSTV VVGLGDALNR AGHQTVLALR EPSLGPVMGL 100
    KGGATGGGYA QVVPMEDINL HFTGDMHALT EAHDTLAALI DNHIQQGNAL 150
    RLDPRQIVWK RVLDINDRAL RQTVIGLGGR TSGVPRQDGF NITVASELMA 200
    VLCLSEDLSD LKRRVNRILI GYNMDKEPVT VGDLQVGGAI TLLLKDAIKP 250
    NLVQTLEHNP AIIHGGPFAN IAHGCNSVLA TQTALQLGEY TVTEAGFGAD 300
    LGGEKFMDIK TPVLGKTPDA VVIVATIRAL KYNGGVKRAD LETENVAALQ 350
    QGSANLKRHI HSMQQYGVPV VVAINRFTSD TDAEVAALEA EVAAIDVPVA 400
    TTTVWADGGA GAMDLADKVV AATQQPSHFT RLSPEHADLM TQMTAITQKI 450
    YGGAQVELSA KAKRQLKTFA QYGWDHLPVC MAKTQYSLTD DAHQLGAPQD 500
    FTIHVREFAP RLGAGFVVAL TGNVLTMPGL PKHPAALDMD IAPDGTISGL 550
    F 551
    Length:551
    Mass (Da):58,459
    Last modified:November 14, 2006 - v1
    Checksum:i8594BA12FBC898F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ63977.1.
    RefSeqiWP_011667763.1. NC_008497.1.
    YP_795008.1. NC_008497.1.

    Genome annotation databases

    EnsemblBacteriaiABJ63977; ABJ63977; LVIS_0834.
    GeneIDi4414735.
    KEGGilbr:LVIS_0834.
    PATRICi22200621. VBILacBre134470_0806.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ63977.1 .
    RefSeqi WP_011667763.1. NC_008497.1.
    YP_795008.1. NC_008497.1.

    3D structure databases

    ProteinModelPortali Q03S45.
    SMRi Q03S45. Positions 3-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387344.LVIS_0834.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ63977 ; ABJ63977 ; LVIS_0834 .
    GeneIDi 4414735.
    KEGGi lbr:LVIS_0834.
    PATRICi 22200621. VBILacBre134470_0806.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LBRE387344:GJ8S-834-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 367 / JCM 1170.

    Entry informationi

    Entry nameiFTHS_LACBA
    AccessioniPrimary (citable) accession number: Q03S45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3