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Protein
Submitted name:

tRNA and rRNA cytosine-C5-methylase

Gene

LVIS_0964

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.SAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei285S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei313S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei332S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei385NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotationImported, RNA-bindingPROSITE-ProRule annotationSAAS annotation, Transferase
Biological processrRNA processingSAAS annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
tRNA and rRNA cytosine-C5-methylaseImported
Gene namesi
Ordered Locus Names:LVIS_0964Imported
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)Imported
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_0964.

Structurei

3D structure databases

ProteinModelPortaliQ03RS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 446SAM_MT_RSMB_NOPInterPro annotationAdd BLAST277

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiLRVNRQH.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR031341. Methyltr_RsmF_N.
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF17125. Methyltr_RsmF_N. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03RS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKNQTPRAL AVEALTRVAG GAYSNLQLEQ TLESHRLSDV DRRFVTNLVY
60 70 80 90 100
GTIQHQLTLE YYLSKFIKPQ QKVLPWVKMT LMVALYQELY LDRVPKRAIF
110 120 130 140 150
NEAIQLAKDR GHEGIRRFVT GVLHAIDRQG LPDLAQIKDP IERLSLQYSV
160 170 180 190 200
PTWLITALQE QVGEDKTMQI LATINQPAAQ SIRANVAVTT AEAVQAALAA
210 220 230 240 250
EGYQVTPSQV AANAFRLDDK AANQSALFAD GAITIQDESA MLPVEALQLR
260 270 280 290 300
PGDQVLDACA APGGKTTQIA AQLDAHSGGK VTALDLHEKK VKLIEANAER
310 320 330 340 350
LHVTDRVDAV ALDARKIDDQ FPKKQFDRIL VDAPCSGLGL IRRKPEIRYE
360 370 380 390 400
KTPQDIQQLQ RVQLDILNAV SKKLKPNGIL VYSTCTILDT ENDEVVAQFL
410 420 430 440
ATHPEFSPMR VTTAQNIKSD RSTDTLKIYP DDFDSDGFFV SAFRRQK
Length:447
Mass (Da):49,708
Last modified:November 14, 2006 - v1
Checksum:i63854CBC2FDDF6F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64098.1.
RefSeqiWP_011667688.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64098; ABJ64098; LVIS_0964.
GeneIDi4413870.
KEGGilbr:LVIS_0964.
PATRICifig|387344.15.peg.940.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ03RS4_LACBA
AccessioniPrimary (citable) accession number: Q03RS4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported