SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q03RH7

- SYL_LACBA

UniProt

Q03RH7 - SYL_LACBA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene
leuS, LVIS_1062
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:LVIS_1062
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809Leucine--tRNA ligaseUniRule annotationPRO_1000009357Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_1062.

Structurei

3D structure databases

ProteinModelPortaliQ03RH7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi581 – 5855"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03RH7-1 [UniParc]FASTAAdd to Basket

« Hide

MAYKHQIIER KWQHYWRANH TFETSDSQTK PKYYVMDMFP YPSGQGLHVG    50
HPEGYTATDI MARLKRMQGF NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT 100
AHNIKNFKRQ IRSLGFSYDW SREINTTDES YYKWTQWIFE QLYKKGLAYE 150
DKIMVNWAPD FMGGTVVANE EVIDGKTERG GYPVYRVPMR QWVLKITAYA 200
DRLIDDLDDL DWPDSIKEMQ RNWIGRSEGA SVFFPVDGQA DTKIEVYTTR 250
PDTLFGATYM VLAPEHAAVA KITTPEQADA VKAYQEAIES KSDLERTDLN 300
KDKTGVFTGA YGINPLSGKK LPIWIGDYVL SSYGTGAIMA VPAHDERDHE 350
FATKFNLPIT QVIEGDADTD ITEAAYTDDG KHINSDFMNG MDKQTAISAA 400
IDWLTEHDAG HKQVNFRLRD WIFSRQRYWG EPIPVIHWEN GETTLVPEDE 450
LPLKLPAAKQ LEPSGTGESP LANLDDWVNV VDENGRKGKR ETNTMPQWAG 500
SSWYFLRYVD PTNDQAIADP EKLKYWMPVD LYIGGAEHAV LHLLYARFWH 550
KFLYDLGVVP TKEPFQKLVN QGMILGTNHE KMSKSKGNVI NPDEIVEKHG 600
ADTLRLYEMF MGPLEASKPW STEGINGSRR WLDRVWRLLI DDNNRLRDRV 650
TMINDGALDK IYNQTVKTVT EDLEAMRFNV AISQLMVFVN EAYKVDSLPM 700
IYMEGFVKLI SPIVPHIAEE LWSLLGHDET IAYAKWPTYD AKQLVEDVVE 750
LVVQVNGKVR AHLKVAKDAT KDAIEAAALA DETVQVHTDG KTVRKVIVVP 800
GKLVNIVAN 809
Length:809
Mass (Da):92,230
Last modified:November 14, 2006 - v1
Checksum:i59458C2565B219C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64195.1.
RefSeqiWP_011667825.1. NC_008497.1.
YP_795226.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64195; ABJ64195; LVIS_1062.
GeneIDi4414232.
KEGGilbr:LVIS_1062.
PATRICi22201085. VBILacBre134470_1038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64195.1 .
RefSeqi WP_011667825.1. NC_008497.1.
YP_795226.1. NC_008497.1.

3D structure databases

ProteinModelPortali Q03RH7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_1062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ64195 ; ABJ64195 ; LVIS_1062 .
GeneIDi 4414232.
KEGGi lbr:LVIS_1062.
PATRICi 22201085. VBILacBre134470_1038.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LBRE387344:GJ8S-1062-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiSYL_LACBA
AccessioniPrimary (citable) accession number: Q03RH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi