Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei584ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBRE387344:G1G6Z-1043-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LVIS_1062
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093571 – 809Leucine--tRNA ligaseAdd BLAST809

Proteomic databases

PRIDEiQ03RH7

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_1062

Structurei

3D structure databases

ProteinModelPortaliQ03RH7
SMRiQ03RH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi581 – 585"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q03RH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYKHQIIER KWQHYWRANH TFETSDSQTK PKYYVMDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI MARLKRMQGF NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT
110 120 130 140 150
AHNIKNFKRQ IRSLGFSYDW SREINTTDES YYKWTQWIFE QLYKKGLAYE
160 170 180 190 200
DKIMVNWAPD FMGGTVVANE EVIDGKTERG GYPVYRVPMR QWVLKITAYA
210 220 230 240 250
DRLIDDLDDL DWPDSIKEMQ RNWIGRSEGA SVFFPVDGQA DTKIEVYTTR
260 270 280 290 300
PDTLFGATYM VLAPEHAAVA KITTPEQADA VKAYQEAIES KSDLERTDLN
310 320 330 340 350
KDKTGVFTGA YGINPLSGKK LPIWIGDYVL SSYGTGAIMA VPAHDERDHE
360 370 380 390 400
FATKFNLPIT QVIEGDADTD ITEAAYTDDG KHINSDFMNG MDKQTAISAA
410 420 430 440 450
IDWLTEHDAG HKQVNFRLRD WIFSRQRYWG EPIPVIHWEN GETTLVPEDE
460 470 480 490 500
LPLKLPAAKQ LEPSGTGESP LANLDDWVNV VDENGRKGKR ETNTMPQWAG
510 520 530 540 550
SSWYFLRYVD PTNDQAIADP EKLKYWMPVD LYIGGAEHAV LHLLYARFWH
560 570 580 590 600
KFLYDLGVVP TKEPFQKLVN QGMILGTNHE KMSKSKGNVI NPDEIVEKHG
610 620 630 640 650
ADTLRLYEMF MGPLEASKPW STEGINGSRR WLDRVWRLLI DDNNRLRDRV
660 670 680 690 700
TMINDGALDK IYNQTVKTVT EDLEAMRFNV AISQLMVFVN EAYKVDSLPM
710 720 730 740 750
IYMEGFVKLI SPIVPHIAEE LWSLLGHDET IAYAKWPTYD AKQLVEDVVE
760 770 780 790 800
LVVQVNGKVR AHLKVAKDAT KDAIEAAALA DETVQVHTDG KTVRKVIVVP

GKLVNIVAN
Length:809
Mass (Da):92,230
Last modified:November 14, 2006 - v1
Checksum:i59458C2565B219C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA Translation: ABJ64195.1
RefSeqiWP_011667825.1, NC_008497.1

Genome annotation databases

EnsemblBacteriaiABJ64195; ABJ64195; LVIS_1062
GeneIDi4414232
KEGGilbr:LVIS_1062
PATRICifig|387344.15.peg.1038

Similar proteinsi

Entry informationi

Entry nameiSYL_LACBA
AccessioniPrimary (citable) accession number: Q03RH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health