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Q03RH7

- SYL_LACBA

UniProt

Q03RH7 - SYL_LACBA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LVIS_1062
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809Leucine--tRNA ligasePRO_1000009357Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_1062.

Structurei

3D structure databases

ProteinModelPortaliQ03RH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03RH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYKHQIIER KWQHYWRANH TFETSDSQTK PKYYVMDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI MARLKRMQGF NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT
110 120 130 140 150
AHNIKNFKRQ IRSLGFSYDW SREINTTDES YYKWTQWIFE QLYKKGLAYE
160 170 180 190 200
DKIMVNWAPD FMGGTVVANE EVIDGKTERG GYPVYRVPMR QWVLKITAYA
210 220 230 240 250
DRLIDDLDDL DWPDSIKEMQ RNWIGRSEGA SVFFPVDGQA DTKIEVYTTR
260 270 280 290 300
PDTLFGATYM VLAPEHAAVA KITTPEQADA VKAYQEAIES KSDLERTDLN
310 320 330 340 350
KDKTGVFTGA YGINPLSGKK LPIWIGDYVL SSYGTGAIMA VPAHDERDHE
360 370 380 390 400
FATKFNLPIT QVIEGDADTD ITEAAYTDDG KHINSDFMNG MDKQTAISAA
410 420 430 440 450
IDWLTEHDAG HKQVNFRLRD WIFSRQRYWG EPIPVIHWEN GETTLVPEDE
460 470 480 490 500
LPLKLPAAKQ LEPSGTGESP LANLDDWVNV VDENGRKGKR ETNTMPQWAG
510 520 530 540 550
SSWYFLRYVD PTNDQAIADP EKLKYWMPVD LYIGGAEHAV LHLLYARFWH
560 570 580 590 600
KFLYDLGVVP TKEPFQKLVN QGMILGTNHE KMSKSKGNVI NPDEIVEKHG
610 620 630 640 650
ADTLRLYEMF MGPLEASKPW STEGINGSRR WLDRVWRLLI DDNNRLRDRV
660 670 680 690 700
TMINDGALDK IYNQTVKTVT EDLEAMRFNV AISQLMVFVN EAYKVDSLPM
710 720 730 740 750
IYMEGFVKLI SPIVPHIAEE LWSLLGHDET IAYAKWPTYD AKQLVEDVVE
760 770 780 790 800
LVVQVNGKVR AHLKVAKDAT KDAIEAAALA DETVQVHTDG KTVRKVIVVP

GKLVNIVAN
Length:809
Mass (Da):92,230
Last modified:November 14, 2006 - v1
Checksum:i59458C2565B219C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64195.1.
RefSeqiYP_795226.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64195; ABJ64195; LVIS_1062.
GeneIDi4414232.
KEGGilbr:LVIS_1062.
PATRICi22201085. VBILacBre134470_1038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64195.1 .
RefSeqi YP_795226.1. NC_008497.1.

3D structure databases

ProteinModelPortali Q03RH7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_1062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ64195 ; ABJ64195 ; LVIS_1062 .
GeneIDi 4414232.
KEGGi lbr:LVIS_1062.
PATRICi 22201085. VBILacBre134470_1038.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LBRE387344:GJ8S-1062-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiSYL_LACBA
AccessioniPrimary (citable) accession number: Q03RH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3