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Q03RH7

- SYL_LACBA

UniProt

Q03RH7 - SYL_LACBA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLBRE387344:GJ8S-1062-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LVIS_1062
    OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
    Taxonomic identifieri387344 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001652: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 809809Leucine--tRNA ligasePRO_1000009357Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi387344.LVIS_1062.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03RH7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03RH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYKHQIIER KWQHYWRANH TFETSDSQTK PKYYVMDMFP YPSGQGLHVG    50
    HPEGYTATDI MARLKRMQGF NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT 100
    AHNIKNFKRQ IRSLGFSYDW SREINTTDES YYKWTQWIFE QLYKKGLAYE 150
    DKIMVNWAPD FMGGTVVANE EVIDGKTERG GYPVYRVPMR QWVLKITAYA 200
    DRLIDDLDDL DWPDSIKEMQ RNWIGRSEGA SVFFPVDGQA DTKIEVYTTR 250
    PDTLFGATYM VLAPEHAAVA KITTPEQADA VKAYQEAIES KSDLERTDLN 300
    KDKTGVFTGA YGINPLSGKK LPIWIGDYVL SSYGTGAIMA VPAHDERDHE 350
    FATKFNLPIT QVIEGDADTD ITEAAYTDDG KHINSDFMNG MDKQTAISAA 400
    IDWLTEHDAG HKQVNFRLRD WIFSRQRYWG EPIPVIHWEN GETTLVPEDE 450
    LPLKLPAAKQ LEPSGTGESP LANLDDWVNV VDENGRKGKR ETNTMPQWAG 500
    SSWYFLRYVD PTNDQAIADP EKLKYWMPVD LYIGGAEHAV LHLLYARFWH 550
    KFLYDLGVVP TKEPFQKLVN QGMILGTNHE KMSKSKGNVI NPDEIVEKHG 600
    ADTLRLYEMF MGPLEASKPW STEGINGSRR WLDRVWRLLI DDNNRLRDRV 650
    TMINDGALDK IYNQTVKTVT EDLEAMRFNV AISQLMVFVN EAYKVDSLPM 700
    IYMEGFVKLI SPIVPHIAEE LWSLLGHDET IAYAKWPTYD AKQLVEDVVE 750
    LVVQVNGKVR AHLKVAKDAT KDAIEAAALA DETVQVHTDG KTVRKVIVVP 800
    GKLVNIVAN 809
    Length:809
    Mass (Da):92,230
    Last modified:November 14, 2006 - v1
    Checksum:i59458C2565B219C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ64195.1.
    RefSeqiWP_011667825.1. NC_008497.1.
    YP_795226.1. NC_008497.1.

    Genome annotation databases

    EnsemblBacteriaiABJ64195; ABJ64195; LVIS_1062.
    GeneIDi4414232.
    KEGGilbr:LVIS_1062.
    PATRICi22201085. VBILacBre134470_1038.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ64195.1 .
    RefSeqi WP_011667825.1. NC_008497.1.
    YP_795226.1. NC_008497.1.

    3D structure databases

    ProteinModelPortali Q03RH7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387344.LVIS_1062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ64195 ; ABJ64195 ; LVIS_1062 .
    GeneIDi 4414232.
    KEGGi lbr:LVIS_1062.
    PATRICi 22201085. VBILacBre134470_1038.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LBRE387344:GJ8S-1062-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 367 / JCM 1170.

    Entry informationi

    Entry nameiSYL_LACBA
    AccessioniPrimary (citable) accession number: Q03RH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3