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Q03QX6

- Q03QX6_LACBA

UniProt

Q03QX6 - Q03QX6_LACBA

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Protein
Thymidine kinase
Gene
tdk, LVIS_1291
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1291-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:LVIS_1291Imported
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)Imported
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi387344.LVIS_1291.

Structurei

3D structure databases

ProteinModelPortaliQ03QX6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03QX6-1 [UniParc]FASTAAdd to Basket

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MAQLFFRYGA MNSGKTIEIL KVAHNYEEQH KRVIIMTSGL DTRDEVGYIA    50
SRIGLKRQAH PIFQDTDLFE EIQRIDAQAN CVLIDEAQFL TKAHVFQLAK 100
VVDELKIPVM TFGLKNDFRN ELFEGSKYLL LYADKIEEMK TICWFCTKKA 150
IMNLRFHNDQ PVYEGEQVQI GGNEAYYPVC RRHYFNPPLD QIGK 194
Length:194
Mass (Da):22,588
Last modified:November 14, 2006 - v1
Checksum:i11B1FE0AEB7930E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64396.1.
RefSeqiYP_795427.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64396; ABJ64396; LVIS_1291.
GeneIDi4414140.
KEGGilbr:LVIS_1291.
PATRICi22201521. VBILacBre134470_1232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64396.1 .
RefSeqi YP_795427.1. NC_008497.1.

3D structure databases

ProteinModelPortali Q03QX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_1291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ64396 ; ABJ64396 ; LVIS_1291 .
GeneIDi 4414140.
KEGGi lbr:LVIS_1291.
PATRICi 22201521. VBILacBre134470_1232.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci LBRE387344:GJ8S-1291-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiQ03QX6_LACBA
AccessioniPrimary (citable) accession number: Q03QX6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi