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Q03QL3

- DEF_LACBA

UniProt

Q03QL3 - DEF_LACBA

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Protein

Peptide deformylase

Gene
def, LVIS_1411
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131Iron By similarity
Metal bindingi156 – 1561Iron By similarity
Active sitei157 – 1571 By similarity
Metal bindingi160 – 1601Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1411-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:LVIS_1411
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Peptide deformylaseUniRule annotationPRO_0000301042Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_1411.

Structurei

3D structure databases

ProteinModelPortaliQ03QL3.
SMRiQ03QL3. Positions 1-186.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243507.
KOiK01462.
OMAiHIDKENP.
OrthoDBiEOG6PZXGQ.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03QL3-1 [UniParc]FASTAAdd to Basket

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MFLMKDIVRD GDPVLRQEAA DVTFPLSEED QQLAKDLMEY LVVSQDPEQC    50
KKYGLRAGVG LAAPQVGVSK KMASVLVPPV EEDGKSPFTD VIINPVIISE 100
SVQAGALTEG EGCLSVDKDV PGFVPRHDRI TLRYYDVNGE KHQVRLKNYP 150
AIVCQHEIDH LHGTLFYDHI NKDQPFSRDD DMIMIE 186
Length:186
Mass (Da):20,837
Last modified:November 14, 2006 - v1
Checksum:iF02C35D243C1AF77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64509.1.
RefSeqiYP_795540.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64509; ABJ64509; LVIS_1411.
GeneIDi4413358.
KEGGilbr:LVIS_1411.
PATRICi22201757. VBILacBre134470_1347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64509.1 .
RefSeqi YP_795540.1. NC_008497.1.

3D structure databases

ProteinModelPortali Q03QL3.
SMRi Q03QL3. Positions 1-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_1411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ64509 ; ABJ64509 ; LVIS_1411 .
GeneIDi 4413358.
KEGGi lbr:LVIS_1411.
PATRICi 22201757. VBILacBre134470_1347.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243507.
KOi K01462.
OMAi HIDKENP.
OrthoDBi EOG6PZXGQ.

Enzyme and pathway databases

BioCyci LBRE387344:GJ8S-1411-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiDEF_LACBA
AccessioniPrimary (citable) accession number: Q03QL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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