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Protein

Peptide deformylase

Gene

def

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi113IronUniRule annotation1
Metal bindingi156IronUniRule annotation1
Active sitei157UniRule annotation1
Metal bindingi160IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:LVIS_1411
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003010421 – 186Peptide deformylaseAdd BLAST186

Proteomic databases

PRIDEiQ03QL3

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_1411

Structurei

3D structure databases

ProteinModelPortaliQ03QL3
SMRiQ03QL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243507
KOiK01462
OMAiMILMKDI

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q03QL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLMKDIVRD GDPVLRQEAA DVTFPLSEED QQLAKDLMEY LVVSQDPEQC
60 70 80 90 100
KKYGLRAGVG LAAPQVGVSK KMASVLVPPV EEDGKSPFTD VIINPVIISE
110 120 130 140 150
SVQAGALTEG EGCLSVDKDV PGFVPRHDRI TLRYYDVNGE KHQVRLKNYP
160 170 180
AIVCQHEIDH LHGTLFYDHI NKDQPFSRDD DMIMIE
Length:186
Mass (Da):20,837
Last modified:November 14, 2006 - v1
Checksum:iF02C35D243C1AF77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA Translation: ABJ64509.1
RefSeqiWP_011668082.1, NC_008497.1

Genome annotation databases

EnsemblBacteriaiABJ64509; ABJ64509; LVIS_1411
GeneIDi4413358
KEGGilbr:LVIS_1411

Similar proteinsi

Entry informationi

Entry nameiDEF_LACBA
AccessioniPrimary (citable) accession number: Q03QL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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