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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140GTPUniRule annotation1
Binding sitei144GTPUniRule annotation1
Binding sitei188GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 26GTPUniRule annotation5
Nucleotide bindingi109 – 111GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:LVIS_1446Imported
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)Imported
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi387344.LVIS_1446.

Structurei

3D structure databases

ProteinModelPortaliQ03QH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 206TubulinInterPro annotationAdd BLAST193
Domaini208 – 325Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03QH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYSLDSAQN NGAIIKVIGV GGGGNNAVNR MIAEDVKGVE FIVANTDVQA
60 70 80 90 100
LEASKAETKI QLGPKLTKGL GAGANPEVGA KAAEESEEAI TEALDGADMV
110 120 130 140 150
FVTAGMGGGT GNGAAPIVAK IAKESGALTV GVVTRPFSFE GPRRGRFAAE
160 170 180 190 200
GVAQMKENVD TLIVIANNRL LEIVDKKTPM MEAFQEADNV LRQGVQGISD
210 220 230 240 250
LITSPGYVNL DFADVKTVMK DQGAALMGIG SANGENRTED ATKKAISSPL
260 270 280 290 300
LEVSIDGAEQ VLLNITGGPD LSLFEAQAAS QIVSDAATSD VNIIFGTSID
310 320 330 340 350
EDLGDEVRVT VIATGIDKKK EEREAAHSRV ARRAESQNRA DNATETPAKE
360 370 380 390 400
TEKDPFGNWD IREPAHRPEP TSSAANTNNE FAGVDKPDFN IFNPNQNDSS
410
ASDDNKSEDT PPFFKRRRK
Length:419
Mass (Da):44,262
Last modified:November 14, 2006 - v1
Checksum:i83B3DD088F999C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64544.1.
RefSeqiWP_011668172.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64544; ABJ64544; LVIS_1446.
GeneIDi4413674.
KEGGilbr:LVIS_1446.
PATRICi22201829. VBILacBre134470_1383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64544.1.
RefSeqiWP_011668172.1. NC_008497.1.

3D structure databases

ProteinModelPortaliQ03QH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387344.LVIS_1446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ64544; ABJ64544; LVIS_1446.
GeneIDi4413674.
KEGGilbr:LVIS_1446.
PATRICi22201829. VBILacBre134470_1383.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ03QH8_LACBA
AccessioniPrimary (citable) accession number: Q03QH8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.