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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:LVIS_1451
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei175 – 195HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei226 – 248HelicalUniRule annotationAdd BLAST23
Transmembranei252 – 274HelicalUniRule annotationAdd BLAST23
Transmembranei301 – 321HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003325371 – 323Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST323

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_1451.

Structurei

3D structure databases

SMRiQ03QH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03QH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNILLPLLG GFIITAAFMP ALIRYFRARH EGQMIREEGP TWHEKKSGTP
60 70 80 90 100
TMGGLLFIVA IAVMTLLTSW VLAPHHMLPT TWILIFILVL YGALGMWDDS
110 120 130 140 150
IKLFHRQNEG LKAWQKMLGQ IVGALILFWV YTHEQLPMAL HVPGIGNWHM
160 170 180 190 200
SGWYAVFVIL WLVGFSNAVN LSDGLDGLVS GLASIAFAAY GIVAWQQAQI
210 220 230 240 250
NIAIFCFAVV GSLLGFLIFN HKPAKIFMGD TGSLALGGAL AAVSILLHHE
260 270 280 290 300
LSLLWIGLIF VIETASVILQ VASFKLTGKR IFLMSPIHHH FEMKGWSEWR
310 320
IDLTFWGIGL VTALSGVWVI LAK
Length:323
Mass (Da):35,813
Last modified:November 14, 2006 - v1
Checksum:i3741CEC4BDEF9A04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64549.1.

Genome annotation databases

EnsemblBacteriaiABJ64549; ABJ64549; LVIS_1451.
KEGGilbr:LVIS_1451.

Similar proteinsi

Entry informationi

Entry nameiMRAY_LACBA
AccessioniPrimary (citable) accession number: Q03QH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 14, 2006
Last modified: July 5, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families