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Protein

Energy-coupling factor transporter ATP-binding protein EcfA2

Gene

ecfA2

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1661-MONOMER.

Protein family/group databases

TCDBi3.A.1.26.9. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Energy-coupling factor transporter ATP-binding protein EcfA2UniRule annotation (EC:3.6.3.-UniRule annotation)
Short name:
ECF transporter A component EcfA2UniRule annotation
Gene namesi
Name:ecfA2UniRule annotation
Synonyms:cbiO2
Ordered Locus Names:LVIS_1661
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Energy-coupling factor transporter ATP-binding protein EcfA2PRO_0000287943Add
BLAST

Interactioni

Subunit structurei

Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).UniRule annotation

Protein-protein interaction databases

DIPiDIP-60218N.
STRINGi387344.LVIS_1661.

Structurei

Secondary structure

1
290
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1311Combined sources
Beta strandi16 – 183Combined sources
Beta strandi20 – 267Combined sources
Beta strandi35 – 395Combined sources
Helixi46 – 527Combined sources
Turni53 – 553Combined sources
Beta strandi60 – 667Combined sources
Beta strandi69 – 713Combined sources
Helixi77 – 826Combined sources
Helixi83 – 864Combined sources
Beta strandi87 – 904Combined sources
Helixi94 – 974Combined sources
Beta strandi100 – 1023Combined sources
Helixi103 – 1075Combined sources
Helixi109 – 1135Combined sources
Helixi118 – 13114Combined sources
Helixi136 – 1383Combined sources
Helixi143 – 1453Combined sources
Helixi148 – 16013Combined sources
Beta strandi165 – 1717Combined sources
Turni172 – 1754Combined sources
Helixi178 – 19316Combined sources
Turni194 – 1963Combined sources
Beta strandi198 – 2025Combined sources
Helixi206 – 2127Combined sources
Beta strandi214 – 2207Combined sources
Beta strandi223 – 2286Combined sources
Helixi230 – 2334Combined sources
Helixi237 – 2426Combined sources
Helixi249 – 25911Combined sources
Helixi271 – 28212Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HUQX-ray3.00A1-290[»]
4HZUX-ray3.53B1-290[»]
4RFSX-ray3.23A1-290[»]
ProteinModelPortaliQ03PY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 246244ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JJB. Bacteria.
COG1122. LUCA.
KOiK16787.
OMAiVIAMKPE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015856. ABC_transpr_CbiO/EcfA_su.
IPR030946. EcfA2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR04521. ECF_ATPase_2. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51246. CBIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03PY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIAFEHVTY TYQAGTPMAH TALTDVSLTV PDRGYLAIIG HTGSGKSTLI
60 70 80 90 100
QQLNALLKPT SGTIKIDEFT ITPETTNAAL KPLRQHVGMV FQFPENQLFE
110 120 130 140 150
ETVRQDIAFG PKNFGMADAD ALALADEMLT TVGLDQSYAE RSPFELSGGQ
160 170 180 190 200
MRRVAIAGVL AMQPKVLVLD EPTAGLDPQG RQEMMRLFAR LHQEQGLTIV
210 220 230 240 250
LVTHQMEDVA QYAEQVAVMH EGRLMKFGTP ADVFSNREWL QDHQLDVPQA
260 270 280 290
AQFARRLRDR GLTFPKQPLT ADQLADYLAQ QWAQRGADHV
Length:290
Mass (Da):32,144
Last modified:November 14, 2006 - v1
Checksum:i3C67CA6CD7B8CC6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64736.1.
RefSeqiWP_011668470.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64736; ABJ64736; LVIS_1661.
GeneIDi4413743.
KEGGilbr:LVIS_1661.
PATRICi22202249. VBILacBre134470_1574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64736.1.
RefSeqiWP_011668470.1. NC_008497.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HUQX-ray3.00A1-290[»]
4HZUX-ray3.53B1-290[»]
4RFSX-ray3.23A1-290[»]
ProteinModelPortaliQ03PY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60218N.
STRINGi387344.LVIS_1661.

Protein family/group databases

TCDBi3.A.1.26.9. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ64736; ABJ64736; LVIS_1661.
GeneIDi4413743.
KEGGilbr:LVIS_1661.
PATRICi22202249. VBILacBre134470_1574.

Phylogenomic databases

eggNOGiENOG4108JJB. Bacteria.
COG1122. LUCA.
KOiK16787.
OMAiVIAMKPE.

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1661-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015856. ABC_transpr_CbiO/EcfA_su.
IPR030946. EcfA2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR04521. ECF_ATPase_2. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51246. CBIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECFA2_LACBA
AccessioniPrimary (citable) accession number: Q03PY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.