Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Energy-coupling factor transporter ATP-binding protein EcfA1

Gene

ecfA1

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.26.9. the atp-binding cassette (abc) superfamily.
3.A.1.28.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Energy-coupling factor transporter ATP-binding protein EcfA1UniRule annotation (EC:3.6.3.-UniRule annotation)
Short name:
ECF transporter A component EcfA1UniRule annotation
Gene namesi
Name:ecfA1UniRule annotation
Synonyms:cbiO1
Ordered Locus Names:LVIS_1662
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002879441 – 279Energy-coupling factor transporter ATP-binding protein EcfA1Add BLAST279

Interactioni

Subunit structurei

Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).UniRule annotation

Protein-protein interaction databases

DIPiDIP-60219N.
STRINGi387344.LVIS_1662.

Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi14 – 17Combined sources4
Turni18 – 21Combined sources4
Beta strandi23 – 30Combined sources8
Beta strandi35 – 40Combined sources6
Beta strandi42 – 44Combined sources3
Helixi46 – 52Combined sources7
Beta strandi54 – 57Combined sources4
Beta strandi60 – 66Combined sources7
Beta strandi73 – 75Combined sources3
Helixi76 – 80Combined sources5
Beta strandi83 – 86Combined sources4
Beta strandi90 – 93Combined sources4
Beta strandi96 – 98Combined sources3
Helixi99 – 109Combined sources11
Helixi114 – 116Combined sources3
Helixi117 – 125Combined sources9
Turni126 – 129Combined sources4
Helixi131 – 133Combined sources3
Helixi138 – 140Combined sources3
Helixi144 – 157Combined sources14
Beta strandi160 – 166Combined sources7
Helixi168 – 170Combined sources3
Helixi173 – 190Combined sources18
Beta strandi193 – 198Combined sources6
Helixi201 – 205Combined sources5
Beta strandi208 – 214Combined sources7
Beta strandi217 – 222Combined sources6
Helixi224 – 227Combined sources4
Helixi228 – 232Combined sources5
Helixi234 – 237Combined sources4
Helixi243 – 253Combined sources11
Helixi265 – 276Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HUQX-ray3.00B1-279[»]
4HZUX-ray3.53A1-279[»]
4RFSX-ray3.23B1-279[»]
ProteinModelPortaliQ03PY5.
SMRiQ03PY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 240ABC transporterUniRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JJB. Bacteria.
COG1122. LUCA.
KOiK16786.
OMAiAARPDIM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015856. ABC_transpr_CbiO/EcfA_su.
IPR030947. EcfA_1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR04520. ECF_ATPase_1. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51246. CBIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03PY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENIISVDH LTYQYDENQA PALTDVSFTV HAGEWLAIVG HNGSGKSTLA
60 70 80 90 100
KSLDGLLPFT QGSVTVGGIT LTPETVWQVR EQIGMIFQNP DNQFVGATVE
110 120 130 140 150
DDVAFGLENR QISRDEMVPR VQAALAQVGM TSFAQREPSS LSGGQKQRVA
160 170 180 190 200
LAGIVAIAPK ILILDEATSM LDPQGRIEML AIVRQLRQQQ NLTVISITHD
210 220 230 240 250
IDEAASADRV LVIDDGRLVD EAVPSQIFER GTQLVEMGLD LPFTEKLKAA
260 270
LRQRGITPPT TYQTAAEMEE WLWQSLSNT
Length:279
Mass (Da):30,527
Last modified:November 14, 2006 - v1
Checksum:iF448B3ABE4FA0E26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64737.1.
RefSeqiWP_011668471.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64737; ABJ64737; LVIS_1662.
GeneIDi4413744.
KEGGilbr:LVIS_1662.
PATRICi22202251. VBILacBre134470_1575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64737.1.
RefSeqiWP_011668471.1. NC_008497.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HUQX-ray3.00B1-279[»]
4HZUX-ray3.53A1-279[»]
4RFSX-ray3.23B1-279[»]
ProteinModelPortaliQ03PY5.
SMRiQ03PY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60219N.
STRINGi387344.LVIS_1662.

Protein family/group databases

TCDBi3.A.1.26.9. the atp-binding cassette (abc) superfamily.
3.A.1.28.2. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ64737; ABJ64737; LVIS_1662.
GeneIDi4413744.
KEGGilbr:LVIS_1662.
PATRICi22202251. VBILacBre134470_1575.

Phylogenomic databases

eggNOGiENOG4108JJB. Bacteria.
COG1122. LUCA.
KOiK16786.
OMAiAARPDIM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015856. ABC_transpr_CbiO/EcfA_su.
IPR030947. EcfA_1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR04520. ECF_ATPase_1. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51246. CBIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECFA1_LACBA
AccessioniPrimary (citable) accession number: Q03PY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.