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Protein

Energy-coupling factor transporter ATP-binding protein EcfA1

Gene

ecfA1

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1662-MONOMER.

Protein family/group databases

TCDBi3.A.1.26.9. the atp-binding cassette (abc) superfamily.
3.A.1.28.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Energy-coupling factor transporter ATP-binding protein EcfA1UniRule annotation (EC:3.6.3.-UniRule annotation)
Short name:
ECF transporter A component EcfA1UniRule annotation
Gene namesi
Name:ecfA1UniRule annotation
Synonyms:cbiO1
Ordered Locus Names:LVIS_1662
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Energy-coupling factor transporter ATP-binding protein EcfA1PRO_0000287944Add
BLAST

Interactioni

Subunit structurei

Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).UniRule annotation

Protein-protein interaction databases

DIPiDIP-60219N.
STRINGi387344.LVIS_1662.

Structurei

Secondary structure

1
279
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 118Combined sources
Beta strandi14 – 174Combined sources
Turni18 – 214Combined sources
Beta strandi23 – 308Combined sources
Beta strandi35 – 406Combined sources
Beta strandi42 – 443Combined sources
Helixi46 – 527Combined sources
Beta strandi54 – 574Combined sources
Beta strandi60 – 667Combined sources
Beta strandi73 – 753Combined sources
Helixi76 – 805Combined sources
Beta strandi83 – 864Combined sources
Beta strandi90 – 934Combined sources
Beta strandi96 – 983Combined sources
Helixi99 – 10911Combined sources
Helixi114 – 1163Combined sources
Helixi117 – 1259Combined sources
Turni126 – 1294Combined sources
Helixi131 – 1333Combined sources
Helixi138 – 1403Combined sources
Helixi144 – 15714Combined sources
Beta strandi160 – 1667Combined sources
Helixi168 – 1703Combined sources
Helixi173 – 19018Combined sources
Beta strandi193 – 1986Combined sources
Helixi201 – 2055Combined sources
Beta strandi208 – 2147Combined sources
Beta strandi217 – 2226Combined sources
Helixi224 – 2274Combined sources
Helixi228 – 2325Combined sources
Helixi234 – 2374Combined sources
Helixi243 – 25311Combined sources
Helixi265 – 27612Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HUQX-ray3.00B1-279[»]
4HZUX-ray3.53A1-279[»]
4RFSX-ray3.23B1-279[»]
ProteinModelPortaliQ03PY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 240235ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JJB. Bacteria.
COG1122. LUCA.
KOiK16786.
OMAiAARPDIM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015856. ABC_transpr_CbiO/EcfA_su.
IPR030947. EcfA_1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR04520. ECF_ATPase_1. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51246. CBIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03PY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENIISVDH LTYQYDENQA PALTDVSFTV HAGEWLAIVG HNGSGKSTLA
60 70 80 90 100
KSLDGLLPFT QGSVTVGGIT LTPETVWQVR EQIGMIFQNP DNQFVGATVE
110 120 130 140 150
DDVAFGLENR QISRDEMVPR VQAALAQVGM TSFAQREPSS LSGGQKQRVA
160 170 180 190 200
LAGIVAIAPK ILILDEATSM LDPQGRIEML AIVRQLRQQQ NLTVISITHD
210 220 230 240 250
IDEAASADRV LVIDDGRLVD EAVPSQIFER GTQLVEMGLD LPFTEKLKAA
260 270
LRQRGITPPT TYQTAAEMEE WLWQSLSNT
Length:279
Mass (Da):30,527
Last modified:November 14, 2006 - v1
Checksum:iF448B3ABE4FA0E26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64737.1.
RefSeqiWP_011668471.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64737; ABJ64737; LVIS_1662.
GeneIDi4413744.
KEGGilbr:LVIS_1662.
PATRICi22202251. VBILacBre134470_1575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64737.1.
RefSeqiWP_011668471.1. NC_008497.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HUQX-ray3.00B1-279[»]
4HZUX-ray3.53A1-279[»]
4RFSX-ray3.23B1-279[»]
ProteinModelPortaliQ03PY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60219N.
STRINGi387344.LVIS_1662.

Protein family/group databases

TCDBi3.A.1.26.9. the atp-binding cassette (abc) superfamily.
3.A.1.28.2. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ64737; ABJ64737; LVIS_1662.
GeneIDi4413744.
KEGGilbr:LVIS_1662.
PATRICi22202251. VBILacBre134470_1575.

Phylogenomic databases

eggNOGiENOG4108JJB. Bacteria.
COG1122. LUCA.
KOiK16786.
OMAiAARPDIM.

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1662-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015856. ABC_transpr_CbiO/EcfA_su.
IPR030947. EcfA_1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR04520. ECF_ATPase_1. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51246. CBIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECFA1_LACBA
AccessioniPrimary (citable) accession number: Q03PY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.