Reviewed, UniProtKB/Swiss-Prot Q03PR5 (ARAA_LACBA)

Names and origin

Protein names

Recommended name:
    L-arabinose isomerase
    EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	LVIS_1740

Organism

Lactobacillus brevis (strain ATCC 367 / JCM 1170) [Complete proteome] [HAMAP]

Taxonomic identifier

387344 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	L-arabinose isomerase HAMAP MF_00519		PRO_0000312609
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q03PR5-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 6E369FFDD29C591C	FASTA	474	53,293
	10 20 30 40 50 60 MLSVPDYEFW FVTGSQHLYG EEQLKSVAKD AQDIADKLNA SGKLPYKVVF KDVMTTAESI 70 80 90 100 110 120 TNFMKEVNYN DNVAGVITWM HTFSPAKNWI RGTELLQKPL LHLATQYLNN IPYADIDFDY 130 140 150 160 170 180 MNLNQSAHGD REYAYINARL NVNNKIVYGY WGDEDVQDQI ARWEDVAVAY NESFKVKVAR 190 200 210 220 230 240 FGDTMRNVAV TEGDKVEAQI KMGWTVDYYG IGDLVEEINK VSDADVDKEY ADLESKYTMV 250 260 270 280 290 300 QGDNDAETYK HSVRVQLQQY LGIKRFLEKG GYTAFTTNFE DLWGMEQLPG LAAQLLIRDG 310 320 330 340 350 360 YGFGAEGDWK TAALGRVMKI MSHNDRTAFM EDYTLDLRKG HEAILGSHML EVDPTIASDK 370 380 390 400 410 420 PRVEVHPLDI GGKADPARLV FTGSEGDAID VTVADFRDGF KMIGYAVDAN KPEGETPNLP 430 440 450 460 470 VAKQLWTPKV GLKTGALEWM KAGGGHHTML SFSLTEEQME DFATMVGMTK AFIK

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000416 Genomic DNA. Translation: ABJ64807.1.
RefSeq	YP_795838.1.
3D structure databases
SMR	Q03PR5. Positions 1-473.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03PR5.
Genome annotation databases
GeneID	4414620.
GenomeReviews	Gene locus LVIS_1740 in contig CP000416_GR.
KEGG	lbr:LVIS_1740.
NMPDR	fig|387344.8.peg.1615.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	DVAVAYN.
PhylomeDB	Q03PR5.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR003762. Lara_isomerase. [Graphical view]
Pfam	PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARAA_LACBA

Accession

Primary (citable) accession number: Q03PR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	November 14, 2006
Last modified:	January 19, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)