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Protein

Glutamate decarboxylase

Gene

LVIS_1847

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1847-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:LVIS_1847Imported
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)Imported
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_1847.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03PG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMLYGKHTH ETDETLKPIF GASAERHDLP KYKLAKHALE PREADRLVRD
60 70 80 90 100
QLLDEGNSRL NLATFCQTYM EPEAVELMKD TLEKNAIDKS EYPRTAEIEN
110 120 130 140 150
RCVNIIANLW HAPEAESFTG TSTIGSSEAC MLAGLAMKFA WRKRAKANGL
160 170 180 190 200
DLTAHQPNIV ISAGYQVCWE KFCVYWDIDM HVVPMDDDHM SLNVDHVLDY
210 220 230 240 250
VDDYTIGIVG IMGITYTGQY DDLARLDAVV ERYNRTTKFP VYIHVDAASG
260 270 280 290 300
GFYTPFIEPE LKWDFRLNNV ISINASGHKY GLVYPGVGWV IWRDQQYLPK
310 320 330 340 350
ELVFKVSYLG GELPTMAINF SHSASQLIGQ YYNFIRFGFD GYREIQEKTH
360 370 380 390 400
DVARYLAKSL TKLGGFSLIN DGHELPLICY ELTADSDREW TLYDLSDRLL
410 420 430 440 450
MKGWQVPTYP LPKNMTDRVI QRIVVRADFG MSMAHDFIDD LTQAIHDLDQ
460
AHIVFHSDPQ PKKYGFTH
Length:468
Mass (Da):53,548
Last modified:November 13, 2006 - v1
Checksum:iDC3F0C336F6BFFD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64910.1.
RefSeqiYP_795941.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64910; ABJ64910; LVIS_1847.
KEGGilbr:LVIS_1847.
PATRICi22202632. VBILacBre134470_1756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64910.1.
RefSeqiYP_795941.1. NC_008497.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387344.LVIS_1847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ64910; ABJ64910; LVIS_1847.
KEGGilbr:LVIS_1847.
PATRICi22202632. VBILacBre134470_1756.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1847-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170Imported.

Entry informationi

Entry nameiQ03PG2_LACBA
AccessioniPrimary (citable) accession number: Q03PG2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2006
Last sequence update: November 13, 2006
Last modified: March 31, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.