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Q03PB4

- RTPR_LACBA

UniProt

Q03PB4 - RTPR_LACBA

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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin.By similarity

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei416 – 4161By similarity
Active sitei418 – 4181By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1898-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LVIS_1898
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi124 ↔ 427Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi387344.LVIS_1898.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 16312Effector region-1By similarityAdd
BLAST
Regioni173 – 321149Effector region-2By similarityAdd
BLAST
Regioni573 – 63462Adenosylcobalamin-binding-1By similarityAdd
BLAST
Regioni693 – 73442Adenosylcobalamin-binding-2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00525.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03PB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTATQASVS LTPEFIAATE KEITPHWGEL GWVTYKRTYA RWLPEQQRNE
60 70 80 90 100
EWPETVKRVV EGNINLDPRL QADTVTPEVL TELTTEAQNL FRLIYGLAAT
110 120 130 140 150
PSGRNLWISG TDYQHRNGDA LNNCWFIAVR PQAYGDSHIL PSYLTQDQVA
160 170 180 190 200
VSMPFSFMFD QLMKGGGVGF SVTPNNVHQM PVVDQTVDLT IVIDPESASY
210 220 230 240 250
ADSVALGAVN RSEWMHDNSL ADVRFYRLPD TREGWVLANA NMMDAHFNST
260 270 280 290 300
NPEKKTKVVL DISDIRPKNA PIHGFGGTAS GPMPLVEMLF DINQILNNAV
310 320 330 340 350
GRQLTAVDCT DMGNMIGKTV VAGNVRRSAE LALGGAEDDA FITMKQDKDQ
360 370 380 390 400
LYHHRWASNN SVAVDSDFTD YAPIADSIQH NGEPGIVNLG LSRNYGRLID
410 420 430 440 450
GRQEGIDEAV EGTNPCGEIS LSNGEPCNLF EVFPSVAEEQ GWQLEDAFGL
460 470 480 490 500
GARYTKRVTF SHYDWEVSRK AIQKNRRIGV SMSGIQDWIL KTFKQRVVTG
510 520 530 540 550
FEAKHDAETG KTFMQPIYNQ AAVNRFNALY QAVVKADQDY SDTLGCQPSI
560 570 580 590 600
KHTTVKPSGT VAKLAGVSEG MHFHYARYLI QRIRFQDSDP LLPALKASGY
610 620 630 640 650
KVEPDVYSQN TMCVEFPVKA AHADEPAFAS AGEVSMAEQF ATQAFLQTYW
660 670 680 690 700
SDNAVSCTVT FQPEEGQDIS DLLLQYRHTI KSTSLLPYSG ADFKQAPKEP
710 720 730 740
IDAATYDAKC QEITADVAEK FAAMTGNHDQ KDIELVDQSD CESGACPIR
Length:749
Mass (Da):82,998
Last modified:November 14, 2006 - v1
Checksum:iBA3CE5E18509931F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64958.1.
RefSeqiYP_795989.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64958; ABJ64958; LVIS_1898.
GeneIDi4412663.
KEGGilbr:LVIS_1898.
PATRICi22202730. VBILacBre134470_1805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64958.1 .
RefSeqi YP_795989.1. NC_008497.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_1898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ64958 ; ABJ64958 ; LVIS_1898 .
GeneIDi 4412663.
KEGGi lbr:LVIS_1898.
PATRICi 22202730. VBILacBre134470_1805.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00525.
OMAi DSLNNCW.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LBRE387344:GJ8S-1898-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiRTPR_LACBA
AccessioniPrimary (citable) accession number: Q03PB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3