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Q03PB4

- RTPR_LACBA

UniProt

Q03PB4 - RTPR_LACBA

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Protein
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
Gene
rtpR, LVIS_1898
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin By similarity.

Enzyme regulationi

Allosterically regulated by ATP and dNTP By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei416 – 4161 By similarity
Active sitei418 – 4181 By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-1898-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LVIS_1898
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001652: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi124 ↔ 427Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi387344.LVIS_1898.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 16312Effector region-1 By similarity
Add
BLAST
Regioni173 – 321149Effector region-2 By similarity
Add
BLAST
Regioni573 – 63462Adenosylcobalamin-binding-1 By similarity
Add
BLAST
Regioni693 – 73442Adenosylcobalamin-binding-2 By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00525.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03PB4-1 [UniParc]FASTAAdd to Basket

« Hide

MNTATQASVS LTPEFIAATE KEITPHWGEL GWVTYKRTYA RWLPEQQRNE    50
EWPETVKRVV EGNINLDPRL QADTVTPEVL TELTTEAQNL FRLIYGLAAT 100
PSGRNLWISG TDYQHRNGDA LNNCWFIAVR PQAYGDSHIL PSYLTQDQVA 150
VSMPFSFMFD QLMKGGGVGF SVTPNNVHQM PVVDQTVDLT IVIDPESASY 200
ADSVALGAVN RSEWMHDNSL ADVRFYRLPD TREGWVLANA NMMDAHFNST 250
NPEKKTKVVL DISDIRPKNA PIHGFGGTAS GPMPLVEMLF DINQILNNAV 300
GRQLTAVDCT DMGNMIGKTV VAGNVRRSAE LALGGAEDDA FITMKQDKDQ 350
LYHHRWASNN SVAVDSDFTD YAPIADSIQH NGEPGIVNLG LSRNYGRLID 400
GRQEGIDEAV EGTNPCGEIS LSNGEPCNLF EVFPSVAEEQ GWQLEDAFGL 450
GARYTKRVTF SHYDWEVSRK AIQKNRRIGV SMSGIQDWIL KTFKQRVVTG 500
FEAKHDAETG KTFMQPIYNQ AAVNRFNALY QAVVKADQDY SDTLGCQPSI 550
KHTTVKPSGT VAKLAGVSEG MHFHYARYLI QRIRFQDSDP LLPALKASGY 600
KVEPDVYSQN TMCVEFPVKA AHADEPAFAS AGEVSMAEQF ATQAFLQTYW 650
SDNAVSCTVT FQPEEGQDIS DLLLQYRHTI KSTSLLPYSG ADFKQAPKEP 700
IDAATYDAKC QEITADVAEK FAAMTGNHDQ KDIELVDQSD CESGACPIR 749
Length:749
Mass (Da):82,998
Last modified:November 14, 2006 - v1
Checksum:iBA3CE5E18509931F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64958.1.
RefSeqiWP_011668579.1. NC_008497.1.
YP_795989.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64958; ABJ64958; LVIS_1898.
GeneIDi4412663.
KEGGilbr:LVIS_1898.
PATRICi22202730. VBILacBre134470_1805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000416 Genomic DNA. Translation: ABJ64958.1 .
RefSeqi WP_011668579.1. NC_008497.1.
YP_795989.1. NC_008497.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 387344.LVIS_1898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ64958 ; ABJ64958 ; LVIS_1898 .
GeneIDi 4412663.
KEGGi lbr:LVIS_1898.
PATRICi 22202730. VBILacBre134470_1805.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00525.
OMAi DSLNNCW.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LBRE387344:GJ8S-1898-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiRTPR_LACBA
AccessioniPrimary (citable) accession number: Q03PB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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