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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei416By similarity1
Active sitei418By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LVIS_1898
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003265371 – 749Adenosylcobalamin-dependent ribonucleoside-triphosphate reductaseAdd BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi124 ↔ 427Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi387344.LVIS_1898.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 163Effector region-1By similarityAdd BLAST12
Regioni173 – 321Effector region-2By similarityAdd BLAST149
Regioni573 – 634Adenosylcobalamin-binding-1By similarityAdd BLAST62
Regioni693 – 734Adenosylcobalamin-binding-2By similarityAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4107VC8. Bacteria.
COG1372. LUCA.
HOGENOMiHOG000068540.
KOiK00525.
OMAiYGLNPCG.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03PB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTATQASVS LTPEFIAATE KEITPHWGEL GWVTYKRTYA RWLPEQQRNE
60 70 80 90 100
EWPETVKRVV EGNINLDPRL QADTVTPEVL TELTTEAQNL FRLIYGLAAT
110 120 130 140 150
PSGRNLWISG TDYQHRNGDA LNNCWFIAVR PQAYGDSHIL PSYLTQDQVA
160 170 180 190 200
VSMPFSFMFD QLMKGGGVGF SVTPNNVHQM PVVDQTVDLT IVIDPESASY
210 220 230 240 250
ADSVALGAVN RSEWMHDNSL ADVRFYRLPD TREGWVLANA NMMDAHFNST
260 270 280 290 300
NPEKKTKVVL DISDIRPKNA PIHGFGGTAS GPMPLVEMLF DINQILNNAV
310 320 330 340 350
GRQLTAVDCT DMGNMIGKTV VAGNVRRSAE LALGGAEDDA FITMKQDKDQ
360 370 380 390 400
LYHHRWASNN SVAVDSDFTD YAPIADSIQH NGEPGIVNLG LSRNYGRLID
410 420 430 440 450
GRQEGIDEAV EGTNPCGEIS LSNGEPCNLF EVFPSVAEEQ GWQLEDAFGL
460 470 480 490 500
GARYTKRVTF SHYDWEVSRK AIQKNRRIGV SMSGIQDWIL KTFKQRVVTG
510 520 530 540 550
FEAKHDAETG KTFMQPIYNQ AAVNRFNALY QAVVKADQDY SDTLGCQPSI
560 570 580 590 600
KHTTVKPSGT VAKLAGVSEG MHFHYARYLI QRIRFQDSDP LLPALKASGY
610 620 630 640 650
KVEPDVYSQN TMCVEFPVKA AHADEPAFAS AGEVSMAEQF ATQAFLQTYW
660 670 680 690 700
SDNAVSCTVT FQPEEGQDIS DLLLQYRHTI KSTSLLPYSG ADFKQAPKEP
710 720 730 740
IDAATYDAKC QEITADVAEK FAAMTGNHDQ KDIELVDQSD CESGACPIR
Length:749
Mass (Da):82,998
Last modified:November 14, 2006 - v1
Checksum:iBA3CE5E18509931F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64958.1.
RefSeqiWP_011668579.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ64958; ABJ64958; LVIS_1898.
GeneIDi4412663.
KEGGilbr:LVIS_1898.
PATRICi22202730. VBILacBre134470_1805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ64958.1.
RefSeqiWP_011668579.1. NC_008497.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387344.LVIS_1898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ64958; ABJ64958; LVIS_1898.
GeneIDi4412663.
KEGGilbr:LVIS_1898.
PATRICi22202730. VBILacBre134470_1805.

Phylogenomic databases

eggNOGiENOG4107VC8. Bacteria.
COG1372. LUCA.
HOGENOMiHOG000068540.
KOiK00525.
OMAiYGLNPCG.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRTPR_LACBA
AccessioniPrimary (citable) accession number: Q03PB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.