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Q03PB4 (RTPR_LACBA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
Ordered Locus Names:LVIS_1898
OrganismLactobacillus brevis (strain ATCC 367 / JCM 1170) [Complete proteome] [HAMAP]
Taxonomic identifier387344 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length749 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Enzyme regulation

Allosterically regulated by ATP and dNTP By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 749749Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326537

Regions

Region152 – 16312Effector region-1 By similarity
Region173 – 321149Effector region-2 By similarity
Region573 – 63462Adenosylcobalamin-binding-1 By similarity
Region693 – 73442Adenosylcobalamin-binding-2 By similarity

Sites

Active site4161 By similarity
Active site4181 By similarity

Amino acid modifications

Disulfide bond124 ↔ 427Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03PB4 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: BA3CE5E18509931F

FASTA74982,998
        10         20         30         40         50         60 
MNTATQASVS LTPEFIAATE KEITPHWGEL GWVTYKRTYA RWLPEQQRNE EWPETVKRVV 

        70         80         90        100        110        120 
EGNINLDPRL QADTVTPEVL TELTTEAQNL FRLIYGLAAT PSGRNLWISG TDYQHRNGDA 

       130        140        150        160        170        180 
LNNCWFIAVR PQAYGDSHIL PSYLTQDQVA VSMPFSFMFD QLMKGGGVGF SVTPNNVHQM 

       190        200        210        220        230        240 
PVVDQTVDLT IVIDPESASY ADSVALGAVN RSEWMHDNSL ADVRFYRLPD TREGWVLANA 

       250        260        270        280        290        300 
NMMDAHFNST NPEKKTKVVL DISDIRPKNA PIHGFGGTAS GPMPLVEMLF DINQILNNAV 

       310        320        330        340        350        360 
GRQLTAVDCT DMGNMIGKTV VAGNVRRSAE LALGGAEDDA FITMKQDKDQ LYHHRWASNN 

       370        380        390        400        410        420 
SVAVDSDFTD YAPIADSIQH NGEPGIVNLG LSRNYGRLID GRQEGIDEAV EGTNPCGEIS 

       430        440        450        460        470        480 
LSNGEPCNLF EVFPSVAEEQ GWQLEDAFGL GARYTKRVTF SHYDWEVSRK AIQKNRRIGV 

       490        500        510        520        530        540 
SMSGIQDWIL KTFKQRVVTG FEAKHDAETG KTFMQPIYNQ AAVNRFNALY QAVVKADQDY 

       550        560        570        580        590        600 
SDTLGCQPSI KHTTVKPSGT VAKLAGVSEG MHFHYARYLI QRIRFQDSDP LLPALKASGY 

       610        620        630        640        650        660 
KVEPDVYSQN TMCVEFPVKA AHADEPAFAS AGEVSMAEQF ATQAFLQTYW SDNAVSCTVT 

       670        680        690        700        710        720 
FQPEEGQDIS DLLLQYRHTI KSTSLLPYSG ADFKQAPKEP IDAATYDAKC QEITADVAEK 

       730        740 
FAAMTGNHDQ KDIELVDQSD CESGACPIR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000416 Genomic DNA. Translation: ABJ64958.1.
RefSeqYP_795989.1. NC_008497.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING387344.LVIS_1898.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ64958; ABJ64958; LVIS_1898.
GeneID4412663.
KEGGlbr:LVIS_1898.
PATRIC22202730. VBILacBre134470_1805.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1372.
HOGENOMHOG000068540.
KOK00525.
OMADSLNNCW.
OrthoDBEOG68DCVH.

Enzyme and pathway databases

BioCycLBRE387344:GJ8S-1898-MONOMER.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_LACBA
AccessionPrimary (citable) accession number: Q03PB4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families