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Q03PB4

- RTPR_LACBA

UniProt

Q03PB4 - RTPR_LACBA

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Enzyme regulationi

    Allosterically regulated by ATP and dNTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei416 – 4161By similarity
    Active sitei418 – 4181By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Enzyme and pathway databases

    BioCyciLBRE387344:GJ8S-1898-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    Ordered Locus Names:LVIS_1898
    OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
    Taxonomic identifieri387344 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001652: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 749749Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi124 ↔ 427Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi387344.LVIS_1898.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni152 – 16312Effector region-1By similarityAdd
    BLAST
    Regioni173 – 321149Effector region-2By similarityAdd
    BLAST
    Regioni573 – 63462Adenosylcobalamin-binding-1By similarityAdd
    BLAST
    Regioni693 – 73442Adenosylcobalamin-binding-2By similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000068540.
    KOiK00525.
    OMAiDSLNNCW.
    OrthoDBiEOG68DCVH.

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q03PB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTATQASVS LTPEFIAATE KEITPHWGEL GWVTYKRTYA RWLPEQQRNE    50
    EWPETVKRVV EGNINLDPRL QADTVTPEVL TELTTEAQNL FRLIYGLAAT 100
    PSGRNLWISG TDYQHRNGDA LNNCWFIAVR PQAYGDSHIL PSYLTQDQVA 150
    VSMPFSFMFD QLMKGGGVGF SVTPNNVHQM PVVDQTVDLT IVIDPESASY 200
    ADSVALGAVN RSEWMHDNSL ADVRFYRLPD TREGWVLANA NMMDAHFNST 250
    NPEKKTKVVL DISDIRPKNA PIHGFGGTAS GPMPLVEMLF DINQILNNAV 300
    GRQLTAVDCT DMGNMIGKTV VAGNVRRSAE LALGGAEDDA FITMKQDKDQ 350
    LYHHRWASNN SVAVDSDFTD YAPIADSIQH NGEPGIVNLG LSRNYGRLID 400
    GRQEGIDEAV EGTNPCGEIS LSNGEPCNLF EVFPSVAEEQ GWQLEDAFGL 450
    GARYTKRVTF SHYDWEVSRK AIQKNRRIGV SMSGIQDWIL KTFKQRVVTG 500
    FEAKHDAETG KTFMQPIYNQ AAVNRFNALY QAVVKADQDY SDTLGCQPSI 550
    KHTTVKPSGT VAKLAGVSEG MHFHYARYLI QRIRFQDSDP LLPALKASGY 600
    KVEPDVYSQN TMCVEFPVKA AHADEPAFAS AGEVSMAEQF ATQAFLQTYW 650
    SDNAVSCTVT FQPEEGQDIS DLLLQYRHTI KSTSLLPYSG ADFKQAPKEP 700
    IDAATYDAKC QEITADVAEK FAAMTGNHDQ KDIELVDQSD CESGACPIR 749
    Length:749
    Mass (Da):82,998
    Last modified:November 14, 2006 - v1
    Checksum:iBA3CE5E18509931F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ64958.1.
    RefSeqiWP_011668579.1. NC_008497.1.
    YP_795989.1. NC_008497.1.

    Genome annotation databases

    EnsemblBacteriaiABJ64958; ABJ64958; LVIS_1898.
    GeneIDi4412663.
    KEGGilbr:LVIS_1898.
    PATRICi22202730. VBILacBre134470_1805.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000416 Genomic DNA. Translation: ABJ64958.1 .
    RefSeqi WP_011668579.1. NC_008497.1.
    YP_795989.1. NC_008497.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387344.LVIS_1898.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ64958 ; ABJ64958 ; LVIS_1898 .
    GeneIDi 4412663.
    KEGGi lbr:LVIS_1898.
    PATRICi 22202730. VBILacBre134470_1805.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000068540.
    KOi K00525.
    OMAi DSLNNCW.
    OrthoDBi EOG68DCVH.

    Enzyme and pathway databases

    BioCyci LBRE387344:GJ8S-1898-MONOMER.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 367 / JCM 1170.

    Entry informationi

    Entry nameiRTPR_LACBA
    AccessioniPrimary (citable) accession number: Q03PB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3