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Q03NR9 (THIM_LACBA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:LVIS_2099
OrganismLactobacillus brevis (strain ATCC 367 / JCM 1170) [Complete proteome] [HAMAP]
Taxonomic identifier387344 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021514

Sites

Binding site411Substrate; via amide nitrogen By similarity
Binding site1171ATP By similarity
Binding site1631ATP By similarity
Binding site1901Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03NR9 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: D7164C18BBE7A795

FASTA26227,015
        10         20         30         40         50         60 
MKLALLDDLR TQNPIVFNIS NFVTVQDVAN GLNALGASPI MSEEPAEAGE MVGLAGGVCL 

        70         80         90        100        110        120 
NLGAFTQAQI QQIRTVGQQA NAQHKPLVID PVAVGAVQYR KQVATGLLAD FHPDVIRGNA 

       130        140        150        160        170        180 
GEIAALADIS WQAKGIDAGE GAGDLVAIAQ ACAQKLDCVV ILSGPTDIIT DGTRVVKVLN 

       190        200        210        220        230        240 
GTPLFQVHVG SGDMLSSIVA AFCAVTPDTF EAAQTACLVF AAIGQRVVQT VPDVGAGSFT 

       250        260 
VHLLDALQST TVAQIEAVAA YE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000416 Genomic DNA. Translation: ABJ65153.1.
RefSeqYP_796184.1. NC_008497.1.

3D structure databases

ProteinModelPortalQ03NR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING387344.LVIS_2099.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ65153; ABJ65153; LVIS_2099.
GeneID4413108.
KEGGlbr:LVIS_2099.
PATRIC22203132. VBILacBre134470_2005.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycLBRE387344:GJ8S-2099-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_LACBA
AccessionPrimary (citable) accession number: Q03NR9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways