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Protein

Proline iminopeptidase

Gene

pip

Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Releases the N-terminal proline from various substrates.By similarity

Catalytic activityi

Release of N-terminal proline from a peptide.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051NucleophileBy similarity
Active sitei245 – 2451By similarity
Active sitei272 – 2721Proton donorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-2232-MONOMER.

Protein family/group databases

ESTHERilacba-pip. Proline_iminopeptidase.
MEROPSiS33.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline iminopeptidaseBy similarity (EC:3.4.11.5)
Short name:
PIPBy similarity
Alternative name(s):
Prolyl aminopeptidaseBy similarity
Short name:
PAPBy similarity
Gene namesi
Name:pipBy similarity
Synonyms:pepIBy similarity
Ordered Locus Names:LVIS_2232
OrganismiLactobacillus brevis (strain ATCC 367 / JCM 1170)
Taxonomic identifieri387344 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001652 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Proline iminopeptidasePRO_0000406322Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387344.LVIS_2232.

Structurei

3D structure databases

ProteinModelPortaliQ03NE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Sequence analysis

Phylogenomic databases

eggNOGiENOG4107RCM. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000026004.
KOiK01259.
OMAiTWYRVTG.
OrthoDBiEOG6R87CN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005945. Pro_imino_pep.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005539. Pept_S33_TRI_F1. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01250. pro_imino_pep_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03NE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIQEEYMPF RAYQTYYRVV GDLRSPLTPL LLLHGGPGST HNYFEAFDQL
60 70 80 90 100
AMATGRPIVM YDQLGCGRSS IPTDPHLWQA ATWVAELRAL RAYLKLDCVH
110 120 130 140 150
LLGQSWGGML ALIYLCDDQP RGIQSVILAS TLSSAHLWAR EQHRLIQFMS
160 170 180 190 200
TTDQAAIHQA EMTGDFTTPA YLAANERFMI QHATGPITEQ TPEFLRRSKR
210 220 230 240 250
LGTAAYTTAW GPNEYFPTGT LRDYDYTAKL AQLPYPTLVT SGVNDLCTPL
260 270 280 290
VAKTMVDQLP HAEWTLFPHS RHMAFIDEPA AYQARLTQWL AAHDEVTDD
Length:299
Mass (Da):33,711
Last modified:November 14, 2006 - v1
Checksum:iD19504D895D360ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ65282.1.
RefSeqiWP_011668803.1. NC_008497.1.

Genome annotation databases

EnsemblBacteriaiABJ65282; ABJ65282; LVIS_2232.
GeneIDi4413784.
KEGGilbr:LVIS_2232.
PATRICi22203400. VBILacBre134470_2137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000416 Genomic DNA. Translation: ABJ65282.1.
RefSeqiWP_011668803.1. NC_008497.1.

3D structure databases

ProteinModelPortaliQ03NE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387344.LVIS_2232.

Protein family/group databases

ESTHERilacba-pip. Proline_iminopeptidase.
MEROPSiS33.021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ65282; ABJ65282; LVIS_2232.
GeneIDi4413784.
KEGGilbr:LVIS_2232.
PATRICi22203400. VBILacBre134470_2137.

Phylogenomic databases

eggNOGiENOG4107RCM. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000026004.
KOiK01259.
OMAiTWYRVTG.
OrthoDBiEOG6R87CN.

Enzyme and pathway databases

BioCyciLBRE387344:GJ8S-2232-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005945. Pro_imino_pep.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005539. Pept_S33_TRI_F1. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01250. pro_imino_pep_2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 367 / JCM 1170.

Entry informationi

Entry nameiPIP_LACBA
AccessioniPrimary (citable) accession number: Q03NE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: November 14, 2006
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.