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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi454 – 4618GTPUniRule annotation
Nucleotide bindingi500 – 5045GTPUniRule annotation
Nucleotide bindingi554 – 5574GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE322159:GJ9F-383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:STER_0383
OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Taxonomic identifieri322159 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943Translation initiation factor IF-2PRO_1000008357Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ03M88.
SMRiQ03M88. Positions 718-837, 846-943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 614170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni454 – 4618G1By similarity
Regioni479 – 4835G2By similarity
Regioni500 – 5034G3By similarity
Regioni554 – 5574G4By similarity
Regioni590 – 5923G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNSAHAGK.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03M88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKRLYEIA KEVGVESKVI VAKAQELGLS VKSHSSSVEE ADANRITSSL
60 70 80 90 100
KAGTAKDESK PAPKATPTPK EEKVEPKVDK ASVAKSAPAK ETSKAEVKEA
110 120 130 140 150
SVALKKPKSR NFKAEREARA KAEAERRKNG GGRDNRNRNQ QGNDQGKRHN
160 170 180 190 200
NDRRNQKGNG QGDHNKGNRD NSTNHDRNFQ GKLRNDQNQN NRRDNARNNQ
210 220 230 240 250
AGPRIDLKAR AAALKAEQNA EYSRQSETRF REEKAAEQRR AKEQEKARKE
260 270 280 290 300
KQQAEVAVQK AAAETKPAPK PAPVAPQSAP TAQVQDTRRK KVRPNKSRDN
310 320 330 340 350
HRVNEDGPKQ TRNNKWNNQN QVRNQRNSNW NKNKNKKGKN NRGNSAPKLV
360 370 380 390 400
TERKFHELPK EFEYTEGMTV AEIAKRIKRE PAEIVKKLFM MGVMATQNQS
410 420 430 440 450
LDGDTIELLM VDYGIEATKK EEVDNADIER FFVDEDYLNK DAMVERAPVV
460 470 480 490 500
TIMGHVDHGK TTLLDTLRNS RVATGEAGGI TQHIGAYQIE EGGKKITFLD
510 520 530 540 550
TPGHAAFTSM RARGASVTDI TVLIVAADDG VMPQTIEAIN HSKAAGVPII
560 570 580 590 600
VAINKIDKPD ANPERVIGEL AEHGVISTAW GGDSEFVEIS AKFGQNIEEL
610 620 630 640 650
LETILLVAEV EELKADPTVR AIGTVIEARL DKGKGAVATL LVQQGTLNVQ
660 670 680 690 700
DPIVVGNTFG RVRAMTNDLG RRIKTAGPSA PVSITGLNEA PMAGDHFAVY
710 720 730 740 750
EDEKAARAAG EERAKRALMK QRQQTHRVSL DNLFDTLKAG EMKTVNVIIK
760 770 780 790 800
ADVQGSVEAL AASLLKIDVE GVRVNVVHSA VGAINESDIT LAEASDAVVI
810 820 830 840 850
GFNVRPTPQA RQQAETDEVE IRLHSIIYKV IEEIEDAMKG MLDPEFEEKI
860 870 880 890 900
IGEAVIRETF KVSKVGTIGG FMVTNGKITR DSSARVIRDG VVIFDGKLAS
910 920 930 940
LKHYKDDVKE VGNAQEGGLT IENYNDIKVD DVIEAYIMEE IKR
Length:943
Mass (Da):103,824
Last modified:November 14, 2006 - v1
Checksum:iE66470CAF95BBC1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000419 Genomic DNA. Translation: ABJ65684.1.
RefSeqiWP_011680757.1. NC_008532.1.
YP_819880.1. NC_008532.1.

Genome annotation databases

EnsemblBacteriaiABJ65684; ABJ65684; STER_0383.
KEGGiste:STER_0383.
PATRICi19797975. VBIStrThe129203_0356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000419 Genomic DNA. Translation: ABJ65684.1.
RefSeqiWP_011680757.1. NC_008532.1.
YP_819880.1. NC_008532.1.

3D structure databases

ProteinModelPortaliQ03M88.
SMRiQ03M88. Positions 718-837, 846-943.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ65684; ABJ65684; STER_0383.
KEGGiste:STER_0383.
PATRICi19797975. VBIStrThe129203_0356.

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNSAHAGK.
OrthoDBiEOG67HJSV.

Enzyme and pathway databases

BioCyciSTHE322159:GJ9F-383-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-491 / LMD-9.

Entry informationi

Entry nameiIF2_STRTD
AccessioniPrimary (citable) accession number: Q03M88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.