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Q03M88

- IF2_STRTD

UniProt

Q03M88 - IF2_STRTD

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi454 – 4618GTPUniRule annotation
    Nucleotide bindingi500 – 5045GTPUniRule annotation
    Nucleotide bindingi554 – 5574GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTHE322159:GJ9F-383-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:STER_0383
    OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
    Taxonomic identifieri322159 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000772: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 943943Translation initiation factor IF-2PRO_1000008357Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi322159.STER_0383.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03M88.
    SMRiQ03M88. Positions 718-837, 846-943.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini445 – 614170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni454 – 4618G1By similarity
    Regioni479 – 4835G2By similarity
    Regioni500 – 5034G3By similarity
    Regioni554 – 5574G4By similarity
    Regioni590 – 5923G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiRPRINDS.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03M88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKKRLYEIA KEVGVESKVI VAKAQELGLS VKSHSSSVEE ADANRITSSL    50
    KAGTAKDESK PAPKATPTPK EEKVEPKVDK ASVAKSAPAK ETSKAEVKEA 100
    SVALKKPKSR NFKAEREARA KAEAERRKNG GGRDNRNRNQ QGNDQGKRHN 150
    NDRRNQKGNG QGDHNKGNRD NSTNHDRNFQ GKLRNDQNQN NRRDNARNNQ 200
    AGPRIDLKAR AAALKAEQNA EYSRQSETRF REEKAAEQRR AKEQEKARKE 250
    KQQAEVAVQK AAAETKPAPK PAPVAPQSAP TAQVQDTRRK KVRPNKSRDN 300
    HRVNEDGPKQ TRNNKWNNQN QVRNQRNSNW NKNKNKKGKN NRGNSAPKLV 350
    TERKFHELPK EFEYTEGMTV AEIAKRIKRE PAEIVKKLFM MGVMATQNQS 400
    LDGDTIELLM VDYGIEATKK EEVDNADIER FFVDEDYLNK DAMVERAPVV 450
    TIMGHVDHGK TTLLDTLRNS RVATGEAGGI TQHIGAYQIE EGGKKITFLD 500
    TPGHAAFTSM RARGASVTDI TVLIVAADDG VMPQTIEAIN HSKAAGVPII 550
    VAINKIDKPD ANPERVIGEL AEHGVISTAW GGDSEFVEIS AKFGQNIEEL 600
    LETILLVAEV EELKADPTVR AIGTVIEARL DKGKGAVATL LVQQGTLNVQ 650
    DPIVVGNTFG RVRAMTNDLG RRIKTAGPSA PVSITGLNEA PMAGDHFAVY 700
    EDEKAARAAG EERAKRALMK QRQQTHRVSL DNLFDTLKAG EMKTVNVIIK 750
    ADVQGSVEAL AASLLKIDVE GVRVNVVHSA VGAINESDIT LAEASDAVVI 800
    GFNVRPTPQA RQQAETDEVE IRLHSIIYKV IEEIEDAMKG MLDPEFEEKI 850
    IGEAVIRETF KVSKVGTIGG FMVTNGKITR DSSARVIRDG VVIFDGKLAS 900
    LKHYKDDVKE VGNAQEGGLT IENYNDIKVD DVIEAYIMEE IKR 943
    Length:943
    Mass (Da):103,824
    Last modified:November 14, 2006 - v1
    Checksum:iE66470CAF95BBC1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000419 Genomic DNA. Translation: ABJ65684.1.
    RefSeqiYP_819880.1. NC_008532.1.

    Genome annotation databases

    EnsemblBacteriaiABJ65684; ABJ65684; STER_0383.
    GeneIDi4437940.
    KEGGiste:STER_0383.
    PATRICi19797975. VBIStrThe129203_0356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000419 Genomic DNA. Translation: ABJ65684.1 .
    RefSeqi YP_819880.1. NC_008532.1.

    3D structure databases

    ProteinModelPortali Q03M88.
    SMRi Q03M88. Positions 718-837, 846-943.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 322159.STER_0383.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ65684 ; ABJ65684 ; STER_0383 .
    GeneIDi 4437940.
    KEGGi ste:STER_0383.
    PATRICi 19797975. VBIStrThe129203_0356.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi RPRINDS.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci STHE322159:GJ9F-383-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-491 / LMD-9.

    Entry informationi

    Entry nameiIF2_STRTD
    AccessioniPrimary (citable) accession number: Q03M88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3