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Q03M88 (IF2_STRTD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:STER_0383
OrganismStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9) [Complete proteome] [HAMAP]
Taxonomic identifier322159 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length943 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processsmall GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 943943Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000008357

Regions

Nucleotide binding454 – 4618GTP By similarity
Nucleotide binding500 – 5045GTP By similarity
Nucleotide binding554 – 5574GTP By similarity
Region448 – 596149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q03M88 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: E66470CAF95BBC1B

FASTA943103,824
        10         20         30         40         50         60 
MSKKRLYEIA KEVGVESKVI VAKAQELGLS VKSHSSSVEE ADANRITSSL KAGTAKDESK 

        70         80         90        100        110        120 
PAPKATPTPK EEKVEPKVDK ASVAKSAPAK ETSKAEVKEA SVALKKPKSR NFKAEREARA 

       130        140        150        160        170        180 
KAEAERRKNG GGRDNRNRNQ QGNDQGKRHN NDRRNQKGNG QGDHNKGNRD NSTNHDRNFQ 

       190        200        210        220        230        240 
GKLRNDQNQN NRRDNARNNQ AGPRIDLKAR AAALKAEQNA EYSRQSETRF REEKAAEQRR 

       250        260        270        280        290        300 
AKEQEKARKE KQQAEVAVQK AAAETKPAPK PAPVAPQSAP TAQVQDTRRK KVRPNKSRDN 

       310        320        330        340        350        360 
HRVNEDGPKQ TRNNKWNNQN QVRNQRNSNW NKNKNKKGKN NRGNSAPKLV TERKFHELPK 

       370        380        390        400        410        420 
EFEYTEGMTV AEIAKRIKRE PAEIVKKLFM MGVMATQNQS LDGDTIELLM VDYGIEATKK 

       430        440        450        460        470        480 
EEVDNADIER FFVDEDYLNK DAMVERAPVV TIMGHVDHGK TTLLDTLRNS RVATGEAGGI 

       490        500        510        520        530        540 
TQHIGAYQIE EGGKKITFLD TPGHAAFTSM RARGASVTDI TVLIVAADDG VMPQTIEAIN 

       550        560        570        580        590        600 
HSKAAGVPII VAINKIDKPD ANPERVIGEL AEHGVISTAW GGDSEFVEIS AKFGQNIEEL 

       610        620        630        640        650        660 
LETILLVAEV EELKADPTVR AIGTVIEARL DKGKGAVATL LVQQGTLNVQ DPIVVGNTFG 

       670        680        690        700        710        720 
RVRAMTNDLG RRIKTAGPSA PVSITGLNEA PMAGDHFAVY EDEKAARAAG EERAKRALMK 

       730        740        750        760        770        780 
QRQQTHRVSL DNLFDTLKAG EMKTVNVIIK ADVQGSVEAL AASLLKIDVE GVRVNVVHSA 

       790        800        810        820        830        840 
VGAINESDIT LAEASDAVVI GFNVRPTPQA RQQAETDEVE IRLHSIIYKV IEEIEDAMKG 

       850        860        870        880        890        900 
MLDPEFEEKI IGEAVIRETF KVSKVGTIGG FMVTNGKITR DSSARVIRDG VVIFDGKLAS 

       910        920        930        940 
LKHYKDDVKE VGNAQEGGLT IENYNDIKVD DVIEAYIMEE IKR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000419 Genomic DNA. Translation: ABJ65684.1.
RefSeqYP_819880.1. NC_008532.1.

3D structure databases

ProteinModelPortalQ03M88.
SMRQ03M88. Positions 718-837, 846-943.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING322159.STER_0383.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ65684; ABJ65684; STER_0383.
GeneID4437940.
KEGGste:STER_0383.
PATRIC19797975. VBIStrThe129203_0356.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMADDEYSIC.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycSTHE322159:GJ9F-383-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_STRTD
AccessionPrimary (citable) accession number: Q03M88
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries