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Q03M88

- IF2_STRTD

UniProt

Q03M88 - IF2_STRTD

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Protein

Translation initiation factor IF-2

Gene
infB, STER_0383
Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi454 – 4618GTP By similarity
Nucleotide bindingi500 – 5045GTP By similarity
Nucleotide bindingi554 – 5574GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE322159:GJ9F-383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:STER_0383
OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Taxonomic identifieri322159 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000772: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943Translation initiation factor IF-2UniRule annotationPRO_1000008357Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322159.STER_0383.

Structurei

3D structure databases

ProteinModelPortaliQ03M88.
SMRiQ03M88. Positions 718-837, 846-943.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 614170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni454 – 4618G1 By similarity
Regioni479 – 4835G2 By similarity
Regioni500 – 5034G3 By similarity
Regioni554 – 5574G4 By similarity
Regioni590 – 5923G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiRPRINDS.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03M88-1 [UniParc]FASTAAdd to Basket

« Hide

MSKKRLYEIA KEVGVESKVI VAKAQELGLS VKSHSSSVEE ADANRITSSL    50
KAGTAKDESK PAPKATPTPK EEKVEPKVDK ASVAKSAPAK ETSKAEVKEA 100
SVALKKPKSR NFKAEREARA KAEAERRKNG GGRDNRNRNQ QGNDQGKRHN 150
NDRRNQKGNG QGDHNKGNRD NSTNHDRNFQ GKLRNDQNQN NRRDNARNNQ 200
AGPRIDLKAR AAALKAEQNA EYSRQSETRF REEKAAEQRR AKEQEKARKE 250
KQQAEVAVQK AAAETKPAPK PAPVAPQSAP TAQVQDTRRK KVRPNKSRDN 300
HRVNEDGPKQ TRNNKWNNQN QVRNQRNSNW NKNKNKKGKN NRGNSAPKLV 350
TERKFHELPK EFEYTEGMTV AEIAKRIKRE PAEIVKKLFM MGVMATQNQS 400
LDGDTIELLM VDYGIEATKK EEVDNADIER FFVDEDYLNK DAMVERAPVV 450
TIMGHVDHGK TTLLDTLRNS RVATGEAGGI TQHIGAYQIE EGGKKITFLD 500
TPGHAAFTSM RARGASVTDI TVLIVAADDG VMPQTIEAIN HSKAAGVPII 550
VAINKIDKPD ANPERVIGEL AEHGVISTAW GGDSEFVEIS AKFGQNIEEL 600
LETILLVAEV EELKADPTVR AIGTVIEARL DKGKGAVATL LVQQGTLNVQ 650
DPIVVGNTFG RVRAMTNDLG RRIKTAGPSA PVSITGLNEA PMAGDHFAVY 700
EDEKAARAAG EERAKRALMK QRQQTHRVSL DNLFDTLKAG EMKTVNVIIK 750
ADVQGSVEAL AASLLKIDVE GVRVNVVHSA VGAINESDIT LAEASDAVVI 800
GFNVRPTPQA RQQAETDEVE IRLHSIIYKV IEEIEDAMKG MLDPEFEEKI 850
IGEAVIRETF KVSKVGTIGG FMVTNGKITR DSSARVIRDG VVIFDGKLAS 900
LKHYKDDVKE VGNAQEGGLT IENYNDIKVD DVIEAYIMEE IKR 943
Length:943
Mass (Da):103,824
Last modified:November 14, 2006 - v1
Checksum:iE66470CAF95BBC1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ65684.1.
RefSeqiYP_819880.1. NC_008532.1.

Genome annotation databases

EnsemblBacteriaiABJ65684; ABJ65684; STER_0383.
GeneIDi4437940.
KEGGiste:STER_0383.
PATRICi19797975. VBIStrThe129203_0356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ65684.1 .
RefSeqi YP_819880.1. NC_008532.1.

3D structure databases

ProteinModelPortali Q03M88.
SMRi Q03M88. Positions 718-837, 846-943.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322159.STER_0383.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ65684 ; ABJ65684 ; STER_0383 .
GeneIDi 4437940.
KEGGi ste:STER_0383.
PATRICi 19797975. VBIStrThe129203_0356.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi RPRINDS.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci STHE322159:GJ9F-383-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-491 / LMD-9.

Entry informationi

Entry nameiIF2_STRTD
AccessioniPrimary (citable) accession number: Q03M88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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