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Q03LN3

- TYSY_STRTD

UniProt

Q03LN3 - TYSY_STRTD

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Protein

Thymidylate synthase

Gene

thyA

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSTHE322159:GJ9F-622-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:STER_0622
OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Taxonomic identifieri322159 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000772: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Thymidylate synthasePRO_1000000697Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi322159.STER_0622.

Structurei

3D structure databases

ProteinModelPortaliQ03LN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257898.
KOiK00560.
OMAiTIGHAYG.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03LN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKADTIFKE NITKIMEEGV WSEQARPKYK DGTTANSKYI TGSFAEYDLS
60 70 80 90 100
KGEFPITTLR PIAIKSAIKE VFWIYQDQTN SLDVLEDKYN VHYWNDWEVE
110 120 130 140 150
GVPANNGDKR SIGQRYGAVV KKHDIINRLL AQLEANPWNR RNVISLWDYE
160 170 180 190 200
AFEETAGLQP CAFQTMFDVR RVGEDVYLDA TLTQRSNDML VAHHINAMQY
210 220 230 240 250
VALQMMIAKH FGWKVGKFFY FINNLHIYDN QFEQAEELLK RQPSDCQPRL
260 270 280
VLNVPDETNF FDIKPEDFEL VDYDPVKPQL KFDLAI
Length:286
Mass (Da):33,370
Last modified:November 14, 2006 - v1
Checksum:iD1BF1A1CBCF80690
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ65889.1.
RefSeqiYP_820085.1. NC_008532.1.

Genome annotation databases

EnsemblBacteriaiABJ65889; ABJ65889; STER_0622.
GeneIDi4437085.
KEGGiste:STER_0622.
PATRICi19798492. VBIStrThe129203_0603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ65889.1 .
RefSeqi YP_820085.1. NC_008532.1.

3D structure databases

ProteinModelPortali Q03LN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322159.STER_0622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ65889 ; ABJ65889 ; STER_0622 .
GeneIDi 4437085.
KEGGi ste:STER_0622.
PATRICi 19798492. VBIStrThe129203_0603.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257898.
KOi K00560.
OMAi TIGHAYG.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci STHE322159:GJ9F-622-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-491 / LMD-9.

Entry informationi

Entry nameiTYSY_STRTD
AccessioniPrimary (citable) accession number: Q03LN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3