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Q03L41

- FTHS_STRTD

UniProt

Q03L41 - FTHS_STRTD

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE322159:GJ9F-837-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:STER_0837
OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Taxonomic identifieri322159 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000772: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300550Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322159.STER_0837.

Structurei

3D structure databases

ProteinModelPortaliQ03L41.
SMRiQ03L41. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03L41 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQS VELKPITEVV EKVGIGFDDL ELYGKYKAKL SFDKINEVKD
60 70 80 90 100
DKPGKLILVT AINPTPAGEG KSTMSIGLAD ALNKIGKKTM IALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALLDNHIHQ
160 170 180 190 200
GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGGPLNGIPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DINDLKERLA NIVVAYRYDR TPVYVRDLEI EGALTLILKD
260 270 280 290 300
AIKPNLVQTI YGTPALVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LDIKTPNLPT TPDAVVIVAT LRALKMHGGV AKTDLSEENV
360 370 380 390 400
QAVRDGFSNL KRHVENIRKF GIPAVVAINE FVADTEAEIA ALKELCSEIK
410 420 430 440 450
VPVELASVWA NGADGGIDLA NTVVDVVENG NADYKRLYSD DDSLEEKITK
460 470 480 490 500
IVTEIYGGKS VIFEKKAKNQ LKQFAEFGWD KLPVCMAKTQ YSFSDNQFLL
510 520 530 540 550
GAPEGFDITI REFVPKTGAG FIVALTGDVM TMPGLPKAPA ALKMDVTEDG

TAVGLF
Length:556
Mass (Da):59,782
Last modified:November 14, 2006 - v1
Checksum:i262B062C9C883517
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ66081.1.
RefSeqiYP_820277.1. NC_008532.1.

Genome annotation databases

EnsemblBacteriaiABJ66081; ABJ66081; STER_0837.
GeneIDi4438488.
KEGGiste:STER_0837.
PATRICi19798937. VBIStrThe129203_0821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ66081.1 .
RefSeqi YP_820277.1. NC_008532.1.

3D structure databases

ProteinModelPortali Q03L41.
SMRi Q03L41. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 322159.STER_0837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ66081 ; ABJ66081 ; STER_0837 .
GeneIDi 4438488.
KEGGi ste:STER_0837.
PATRICi 19798937. VBIStrThe129203_0821.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci STHE322159:GJ9F-837-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-491 / LMD-9.

Entry informationi

Entry nameiFTHS_STRTD
AccessioniPrimary (citable) accession number: Q03L41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3