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Q03L41

- FTHS_STRTD

UniProt

Q03L41 - FTHS_STRTD

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTHE322159:GJ9F-837-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:STER_0837
    OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
    Taxonomic identifieri322159 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000772: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300550Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi322159.STER_0837.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03L41.
    SMRiQ03L41. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03L41-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQS VELKPITEVV EKVGIGFDDL ELYGKYKAKL SFDKINEVKD    50
    DKPGKLILVT AINPTPAGEG KSTMSIGLAD ALNKIGKKTM IALREPSLGP 100
    VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALLDNHIHQ 150
    GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGGPLNGIPR EDGFDITVAS 200
    EIMAILCLAT DINDLKERLA NIVVAYRYDR TPVYVRDLEI EGALTLILKD 250
    AIKPNLVQTI YGTPALVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 300
    FGADLGAEKF LDIKTPNLPT TPDAVVIVAT LRALKMHGGV AKTDLSEENV 350
    QAVRDGFSNL KRHVENIRKF GIPAVVAINE FVADTEAEIA ALKELCSEIK 400
    VPVELASVWA NGADGGIDLA NTVVDVVENG NADYKRLYSD DDSLEEKITK 450
    IVTEIYGGKS VIFEKKAKNQ LKQFAEFGWD KLPVCMAKTQ YSFSDNQFLL 500
    GAPEGFDITI REFVPKTGAG FIVALTGDVM TMPGLPKAPA ALKMDVTEDG 550
    TAVGLF 556
    Length:556
    Mass (Da):59,782
    Last modified:November 14, 2006 - v1
    Checksum:i262B062C9C883517
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000419 Genomic DNA. Translation: ABJ66081.1.
    RefSeqiYP_820277.1. NC_008532.1.

    Genome annotation databases

    EnsemblBacteriaiABJ66081; ABJ66081; STER_0837.
    GeneIDi4438488.
    KEGGiste:STER_0837.
    PATRICi19798937. VBIStrThe129203_0821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000419 Genomic DNA. Translation: ABJ66081.1 .
    RefSeqi YP_820277.1. NC_008532.1.

    3D structure databases

    ProteinModelPortali Q03L41.
    SMRi Q03L41. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 322159.STER_0837.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ66081 ; ABJ66081 ; STER_0837 .
    GeneIDi 4438488.
    KEGGi ste:STER_0837.
    PATRICi 19798937. VBIStrThe129203_0821.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci STHE322159:GJ9F-837-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-491 / LMD-9.

    Entry informationi

    Entry nameiFTHS_STRTD
    AccessioniPrimary (citable) accession number: Q03L41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3