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Q03KS6

- PYRF_STRTD

UniProt

Q03KS6 - PYRF_STRTD

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, STER_0980
Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei34 – 341Substrate By similarity
Active sitei63 – 631Proton donor By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei188 – 1881Substrate By similarity
Binding sitei208 – 2081Substrate; via amide nitrogen By similarity
Binding sitei209 – 2091Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSTHE322159:GJ9F-980-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:STER_0980
OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Taxonomic identifieri322159 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000772: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000065954Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi322159.STER_0980.

Structurei

3D structure databases

ProteinModelPortaliQ03KS6.
SMRiQ03KS6. Positions 1-230.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 7010Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiSAYHAIK.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03KS6-1 [UniParc]FASTAAdd to Basket

« Hide

MRENRPVIAL DFPTLEDVKA FLAKFPADEK LYVKIGMELY YAAGPEIIRY    50
VKELGHSIFL DLKLHDIPNT VKSAMRVLSN LGVDMTNVHA AGGVEMMKAA 100
REGLGDGPIL IAVTQLTSTS EEQMRDFQNI QTTLQESVVH YAQKTAEAGL 150
DGVVCSAHEV PKIKEATNQD FICLTPGIRP AGAAVGDQKR VMTPADAHQI 200
GSDYIVVGRP ITQAEDPVAA YHDIKAQWND Q 231
Length:231
Mass (Da):25,286
Last modified:November 14, 2006 - v1
Checksum:i7288CA4E948319AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ66196.1.
RefSeqiYP_820392.1. NC_008532.1.

Genome annotation databases

EnsemblBacteriaiABJ66196; ABJ66196; STER_0980.
GeneIDi4438251.
KEGGiste:STER_0980.
PATRICi19799272. VBIStrThe129203_0988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000419 Genomic DNA. Translation: ABJ66196.1 .
RefSeqi YP_820392.1. NC_008532.1.

3D structure databases

ProteinModelPortali Q03KS6.
SMRi Q03KS6. Positions 1-230.
ModBasei Search...

Protein-protein interaction databases

STRINGi 322159.STER_0980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ66196 ; ABJ66196 ; STER_0980 .
GeneIDi 4438251.
KEGGi ste:STER_0980.
PATRICi 19799272. VBIStrThe129203_0988.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi SAYHAIK.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci STHE322159:GJ9F-980-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-491 / LMD-9.

Entry informationi

Entry nameiPYRF_STRTD
AccessioniPrimary (citable) accession number: Q03KS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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