Q03KF6 (Q03KF6_STRTD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
EC=2.5.1.7 HAMAP-Rule MF_00111

Alternative name(s):
Enoylpyruvate transferase HAMAP-Rule MF_00111
UDP-N-acetylglucosamine enolpyruvyl transferase HAMAP-Rule MF_00111

Gene names

Name:	murA HAMAP-Rule MF_00111
Ordered Locus Names:	STER_1123 EMBL ABJ66316.1

Organism

Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) [Complete proteome] [HAMAP] EMBL ABJ66316.1

Taxonomic identifier

322159 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus thermophilus

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111 SAAS SAAS005750
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111 SAAS SAAS005750
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111 SAAS SAAS005750
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00111 SAAS SAAS005750.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily. HAMAP-Rule MF_00111

Ontologies

Keywords
Biological process	Cell cycle Cell division SAAS SAAS005750 HAMAP-Rule MF_00111 Cell shape Cell wall biogenesis/degradation HAMAP-Rule MF_00111 SAAS SAAS005750 Peptidoglycan synthesis HAMAP-Rule MF_00111 SAAS SAAS005750
Cellular component	Cytoplasm SAAS SAAS005750 HAMAP-Rule MF_00111
Molecular function	Transferase HAMAP-Rule MF_00111 SAAS SAAS005750 EMBL ABJ66316.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	120	1	Proton donor By similarity HAMAP-Rule MF_00111
Amino acid modifications
	Modified residue	120	1	2-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity HAMAP-Rule MF_00111

Sequences

	Sequence		Length	Mass (Da)
	Q03KF6 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 3BFA4BD99BC9F617	FASTA	423	45,198
	10 20 30 40 50 60 MDKIIVKGGN TRLSGEVVIE GAKNSVLPLL AATILASEGQ TTLTNVPILS DVYTMNNVVR 70 80 90 100 110 120 GLDIAVDFDE ENNTVVVDAS GEILDQAPYE YVSKMRASIV VLGPILARNG HAKVSMPGGC 130 140 150 160 170 180 TIGSRPIDLH LKGLEAMGAK ITQVGGDITA TAEKLKGATI YMDFPSVGAT QNLMMAATLA 190 200 210 220 230 240 DGVTTIENAA REPEIVDLAI LLNEMGANVK GAGTEKLVIK GVKSLHGTQH AVIQDRIEAG 250 260 270 280 290 300 TFMVAAAMTS GNVLIKDAIW EHNRPLISKL LEMGVDVKEE DRGIRVKSDV SKLKPVAVKT 310 320 330 340 350 360 LPHPGFPTDM QAQFTALMAV VKGKSSISET VFENRFQHLE EMRRMGLHSE ILRDTAMIHG 370 380 390 400 410 420 GLPLQGARVM STDLRASAAL ILTGMVAEGT TTVGKLTHLD RGYYKFHEKL AKLGAQISRV SEA

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B., Mills D. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-491 / LMD-9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000419 Genomic DNA. Translation: ABJ66316.1.
RefSeq	YP_820512.1. NC_008532.1.
3D structure databases
ProteinModelPortal	Q03KF6.
ModBase	Search...
Protein-protein interaction databases
STRING	322159.STER_1123.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ66316; ABJ66316; STER_1123.
GeneID	4438219.
KEGG	ste:STER_1123.
PATRIC	19799594. VBIStrThe129203_1149.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0766.
HOGENOM	HOG000075602.
KO	K00790.
OMA	SIWALAP.
ProtClustDB	PRK09369.
Enzyme and pathway databases
BioCyc	STHE322159:GJ9F-1123-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.65.10.10. 2 hits.
HAMAP	MF_00111. MurA.
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
PANTHER	PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q03KF6_STRTD

Accession

Primary (citable) accession number: Q03KF6

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	May 29, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)