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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. no protein annotated in this organism
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. no protein annotated in this organism
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:STER_1205
OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Taxonomic identifieri322159 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195351 – 216ATP phosphoribosyltransferaseAdd BLAST216

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ03K77.
SMRiQ03K77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223248.
KOiK00765.
OMAiYVMMDYD.

Family and domain databases

CDDicd13595. PBP2_HisGs. 1 hit.
HAMAPiMF_01018. HisG_Short. 1 hit.
InterProiView protein in InterPro
IPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiView protein in Pfam
PF01634. HisG. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiView protein in PROSITE
PS01316. ATP_P_PHORIBOSYLTR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03K77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNQITIAL TKGRIEKDAV TLLEKAGFNM SFMADKGRNL IFESPDNRFR
60 70 80 90 100
FLLVKAPDVT TYVRHGVADI GIVGKDVLVE HPTGYLEMLD LNFGLCKFCV
110 120 130 140 150
ASTEDYNPND HKRKRIATKY PTIATDYFNQ KGEDVEIISI QGSVEIAPVI
160 170 180 190 200
GLADAIVDIV ETGSTLVANG LKVYEDICRI SARMIVNKAS LKNNKEVLQF
210
IRKIESLVGN EEVPFE
Length:216
Mass (Da):24,031
Last modified:November 14, 2006 - v1
Checksum:i05AE646BA8C0913B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000419 Genomic DNA. Translation: ABJ66395.1.
RefSeqiWP_011681270.1. NC_008532.1.

Genome annotation databases

EnsemblBacteriaiABJ66395; ABJ66395; STER_1205.
KEGGiste:STER_1205.

Similar proteinsi

Entry informationi

Entry nameiHIS1_STRTD
AccessioniPrimary (citable) accession number: Q03K77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 14, 2006
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families