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Protein

ATP phosphoribosyltransferase regulatory subunit

Gene

hisZ

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.UniRule annotation

Miscellaneous

This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. no protein annotated in this organism
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. no protein annotated in this organism
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Biological processi

Keywordsi

Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase regulatory subunitUniRule annotation
Gene namesi
Name:hisZUniRule annotation
Ordered Locus Names:STER_1206
OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Taxonomic identifieri322159 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000162881 – 326ATP phosphoribosyltransferase regulatory subunitAdd BLAST326

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ03K76.
SMRiQ03K76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000018077.
KOiK02502.
OMAiGYELVMP.

Family and domain databases

HAMAPiMF_00125. HisZ. 1 hit.
InterProiView protein in InterPro
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
PANTHERiPTHR43707. PTHR43707. 1 hit.
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03K76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTTLALGM HDKLFKRART MYQIEHCICD LLMTKGFLRI ETPTLEHFEV
60 70 80 90 100
FSDVVDNGNY NFFDKNGDLI SLRPDITSQI GRVIASTQVH TPIKFSYSGK
110 120 130 140 150
VFNYNEEMRG LSNEHTQAGV EIIGFPVHQA LEEAVISAKE ALDVAGVRNY
160 170 180 190 200
KFEFSHAQLL QLIFEELNLP AVKEAELATY IRDKSITGLK EFTKENPSQY
210 220 230 240 250
DKVLEQLPSL FGETTAVLTE ARQLTDNESF LTALDSLEVL TSRLADNLPE
260 270 280 290 300
TTLDLAQLPA VPYYTGIMFK VFGDKVPDAF VSGGRYDKLF ERFGATELTA
310 320
VGWAIDIDSV YQAVHDDVEF GGDMDD
Length:326
Mass (Da):36,634
Last modified:November 14, 2006 - v1
Checksum:iD58B9089D9908F6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000419 Genomic DNA. Translation: ABJ66396.1.
RefSeqiWP_011681271.1. NC_008532.1.

Genome annotation databases

EnsemblBacteriaiABJ66396; ABJ66396; STER_1206.
KEGGiste:STER_1206.

Similar proteinsi

Entry informationi

Entry nameiHISZ_STRTD
AccessioniPrimary (citable) accession number: Q03K76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families