Q03JB9 (TRPC_STRTD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	STER_1551

Organism

Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) [Complete proteome] [HAMAP]

Taxonomic identifier

322159 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000095902

Sequences

	Sequence		Length	Mass (Da)
	Q03JB9 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: B14F5F9BAC2AEDF7	FASTA	255	28,245
	10 20 30 40 50 60 MSKAFLPTIL EQKEKEVAQL VMEDLQPLRQ TYRLYDFLKS NQNKLQIISE VKKASPSMGD 70 80 90 100 110 120 INLDVDIVAQ AKTYEENGAA MISVLTDEVF FKGDISYLKE ISTQVAIPTL AKDFIIDEKQ 130 140 150 160 170 180 IVRSRNAGAT VILLIVAALP EARLKELYDF ATSLGLEVLV ETHNLPELEV AHRIGAEIIG 190 200 210 220 230 240 VNNRNLVTFE TDINTSLELS THFKDKPVYI SESAIFTGQD AALVAPYFNG ILVGTALMTA 250 DNVAKKVKEL QIDKG

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-491 / LMD-9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000419 Genomic DNA. Translation: ABJ66703.1.
RefSeq	YP_820899.1. NC_008532.1.
3D structure databases
ProteinModelPortal	Q03JB9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03JB9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000061046; EBSTRP00000056702; EBSTRG00000061036.
GeneID	4437825.
GenomeReviews	Gene locus STER_1551 in contig CP000419_GR.
KEGG	ste:STER_1551.
PATRIC	19800492. VBIStrThe129203_1594.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000029214.
HOGENOM	HBG540956.
OMA	FETDINT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	STHE322159:STER_1551-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRTD

Accession

Primary (citable) accession number: Q03JB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program