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Q03J02

- PROB_STRTD

UniProt

Q03J02 - PROB_STRTD

Protein

Glutamate 5-kinase

Gene

proB

Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141ATPUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Binding sitei157 – 1571Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi177 – 1782ATPUniRule annotation
    Nucleotide bindingi219 – 2257ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTHE322159:GJ9F-1676-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:STER_1676
    OrganismiStreptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
    Taxonomic identifieri322159 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000772: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Glutamate 5-kinasePRO_1000081115Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi322159.STER_1676.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03J02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiADDFDSR.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03J02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRNFDSVKR LVIKIGTSSL VLPSGKINLE KIDQLAFVIS SLHNKGIEVV    50
    LVSSGAMGFG LNVLDLETRP AEVGKQQAVS SVGQVAMMSL YSQVFSHYQT 100
    KVSQLLLTRD VVEYPESLAN AINAFESLFE LGVVPIVNEN DAVSVDEMDH 150
    ATKFGDNDRL SAIVAKVVGA DLLIMLSDID GLFDKNPNVY EDATLRSYVP 200
    EITEEILASA GAAGSKFGTG GMMSKIKSAQ MVFENQSQMI LMNGENPRDI 250
    LRVLEGAKIG TLFKQED 267
    Length:267
    Mass (Da):28,977
    Last modified:November 14, 2006 - v1
    Checksum:i68448B8872DF357E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000419 Genomic DNA. Translation: ABJ66820.1.
    RefSeqiYP_821016.1. NC_008532.1.

    Genome annotation databases

    EnsemblBacteriaiABJ66820; ABJ66820; STER_1676.
    GeneIDi4438571.
    KEGGiste:STER_1676.
    PATRICi19800738. VBIStrThe129203_1716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000419 Genomic DNA. Translation: ABJ66820.1 .
    RefSeqi YP_821016.1. NC_008532.1.

    3D structure databases

    ProteinModelPortali Q03J02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 322159.STER_1676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ66820 ; ABJ66820 ; STER_1676 .
    GeneIDi 4438571.
    KEGGi ste:STER_1676.
    PATRICi 19800738. VBIStrThe129203_1716.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi ADDFDSR.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci STHE322159:GJ9F-1676-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-491 / LMD-9.

    Entry informationi

    Entry nameiPROB_STRTD
    AccessioniPrimary (citable) accession number: Q03J02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3